Emanuel V. Capela
  PhD Student  
   
  extension: 24943  
  e-mail: emanuelcapela@ua.pt  
  department: Chemistry  
  office: 29.3.3  
   
  supervisor: Mara Guadalupe Freire Martins  
  co-supervisor: Ana Margarida Azevedo (IST)  
  research line: L3 - Sustainability and Health
 
  research group: G5 - Biomedical and Biomimetic Materials
 
isi web of knowledgeSM search factor: Capela EV  
  direct url: http://www.ciceco.ua.pt/emanuelcapela  
     
short CV

Emanuel V. Capela is currently a PhD student/researcher at the research group "Process and Product Applied Thermodynamics" (PATh), CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal in collaboration with Institute for Bioengeneering and Biosciences (iBB), Department of Bioengeneering, Instituto Superior Técnico, University of Lisbon, Portugal. 
His research activities are mainly focused in the production of monoclonal antibodies (mAbs) by mammalian cell technology and in the design of integrated systems for the selective extraction and purification of mAbs, directly from the complex medium, envisaging the process integration and intensification. Moreover, he has been working with a new class of solvents, ionic liquids, where his scientific interest devoted to these compounds includes the characterization of their properties and the evaluation of their potential in the establishment of extractive platforms for value-added compounds, in particular for biopharmaceuticals.
Born on 24 of June of 1993 at Porto, Portugal, obtained his BSc degree in Biochemistry from University of Aveiro, Portugal, in 2014, and his MSc degree in Biochemistry - Biomolecular Methods from the same institution in 2016.

Research activities

The main goal of the research activities of Emanuel V. Capela is to develop alternative, innovative and scalable downstream processes for the extraction and purification of biopharmaceuticals. In the past years, he was dedicated to develop a sustainable platform for the extraction and purification of Immunoglobulin Y (IgY) from egg yolk, using aqueous biphasic systems (ABS). Recently, he started working in the production of monoclonal antibodies (mAbs) by mammalian cell technology and in the design of an integrated system for the selective extraction (capture) and purification (polishing) of mAbs, directly from a complex medium, envisaging process integration and intensification.

Scientific interests

Emanuel V. Capela has been mainly working with a new class of solvents, the ionic liquids. The scientific interest devoted to these compounds includes the characterization of their properties and their use as phase-forming compounds of aqueous biphasic systems. Moreover, he have been studying their potential in the establishment of extractive platforms for value-added compounds, in particular for amino acids and biopharmaceuticals.

Selected communications

Oral communications by invitation

  • Ana Rita R. Teles, Emanuel V. Capela, Rafael S. Carmo, Joćo A.P. Coutinho, Armando J.D. Silvestre, Mara G. Freire; “Solvatochromic parameters of deep eutectic solvents formed by ammonium-based salts and carboxylic acids”. PATh Spring Workshop 2017 – 2nd edition – Deep Eutectis Solvents (DES), Aveiro, Portugal, June 2017.

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Selective separation of amino acids using aqueous biphasic systems composed of ionic liquids”. PATh Spring Workshop 2016, Ķlhavo, Aveiro, Portugal, May 2016.

 

  • Helena Passos, Teresa B. V. Dinis, Emanuel V. Capela, Pedro P. Madeira, Mara G. Freire, Joćo A.P. Coutinho; “New Insights into the Physicochemical Behaviour of Ionic-Liquid-based Aqueous Biphasic Systems”. PATh Spring Workshop 2016, Ķlhavo, Aveiro, Portugal, May 2016.

 

Other oral communications

  • Emanuel V. Capela, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Mara G. Freire, Ana M. Azevedo; “Ionic-liquid-based strategies for monoclonal antibodies downstream processing”. Bioprocess Engineering Session, UBI-HSR 2017, II International Congress in Health Sciences Research: Towards Innovation and Entrepreneurship - Trends in Biotechnology for Biomedical Applications, Covilhć, Portugal, May 2017.

 

  • Emanuel V. Capela, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Integration of capture and polishing of monoclonal antibodies from cell culture supernatants using ionic-liquids-based approaches”. V ENEQUI, V National Meeting of Chemistry Students, Coimbra, Portugal, April 2017. [Prize under the best scientific poster presented in IV ENEQUI]

 

  • Emanuel V. Capela, Mafalda R. Almeida, Joćo A.P. Coutinho, Mara G. Freire; “Exploring ionic liquids for the development of a purification platform for therapeutic immunoglobulin Y (IgY) from egg yolk”. XXIIELGQ, XXII Encontro Luso-Galego de Quķmica, Braganēa, Portugal, November 2016.

 

  • Emanuel V. Capela, Isabel Campos-Pinto, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Novel Systems for the Extraction and Purification of Monoclonal Antibodies directly from CHO Cell Cultures Supernatants using Aqueous Biphasic Systems comprising Ionic Liquids”. ISPPP2016, International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2016, Salzburg, Austria, November 2016.

 

  • Emanuel V. Capela, Isabel Campos-Pinto, Sara A. S. L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Development of Integrated Systems for Extraction and Purification of Monoclonal Antibodies directly from CHO Cell Cultures Supernatants using Aqueous Biphasic Systems composed of Ionic Liquids as Adjuvants”. Medicinal Chemistry Session, 5th PYCheM & 1st EYCheM, 5th Portuguese Young Chemists Meeting and 1st European Young Chemists Meeting, Guimarćes, Portugal, April 2016.

 

  • Emanuel Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Aqueous biphasic systems composed of ionic liquids and amino acids as remarkable selective extraction approaches”. III ENEQUI, III National Chemistry Students Meeting, Aveiro, Portugal, March 2015 [1 out of 5 oral communications selected].

 

Poster communications

  • Emanuel V. Capela, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Novel ionic-liquid-based strategies for the downstream processing of monoclonal antibodies”. RD 2017, University of Aveiro (UA) Research Day 2017, Aveiro, Portugal, June 2017. [Selected poster to represent G5 - Biomedical and Biomimetic Materials research group from CICECO]

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Remarkable platforms for the selective separation of amino acids based on the use of aqueous biphasic systems composed of ionic liquids”. IMIL2017, Iberoamerican Meeting on Ionic Liquids, Santos, Sćo Paulo, Brazil, April 2017.

 

  • Emanuel V. Capela, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Exploring the use of ionic liquids in the extraction and purification of monoclonal antibodies directly from CHO cell culture supernatants”. IMIL2017, Iberoamerican Meeting on Ionic Liquids, Santos, Sćo Paulo, Brazil, April 2017.

 

  • Emanuel V. Capela, Sara A.S.L. Rosa, Joćo A.P. Coutinho, M. Raquel Aires-Barros, Mara G. Freire, Ana M. Azevedo; “Purification of monoclonal antibodies from cell culture supernatants using aqueous biphasic systems constituted by ionic liquids”. III ENEBT, III National Meeting of Biotechnology Students, Aveiro, Portugal, March 2017.

 

  • Emanuel V. Capela, Maria V. Quental, Pedro Domingues, Joćo A.P. Coutinho, Mara G. Freire; “Efficient separation of aromatic and aliphatic amino acid mixtures using ionic-liquid-based processes”. III ENEBT, III National Meeting of Biotechnology Students, Aveiro, Portugal, March 2017.

 

  • Emanuel V. Capela, Ana Rita R. Teles, Ana Filipa M. Clįudio, Joćo A.P. Coutinho, Mara G. Freire; “Characterization of the solvatochromic parameters of binary mixtures of ionic liquids: experimental and COSMO-RS approaches”. ILWS2017, Ionic Liquids Winter School, Oporto, Portugal, February 2017.

 

  • Emanuel V. Capela, Mafalda R. Almeida, Joćo A.P. Coutinho, Mara G. Freire; “Exploring ionic liquids for the development of a purification platform for therapeutic immunoglobulin Y (IgY) from egg yolk”. ISPPP2016, International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2016, Salzburg, Austria, November 2016.

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “High-efficient approach for the selective separation of amino acids based on the use of aqueous biphasic systems composed of ionic liquids”. ISPPP2016, International Symposium on the Separation of Proteins, Peptides and Polynucleotides 2016, Salzburg, Austria, November 2016.

 

  • Emanuel V. Capela, Isabel Campos-Pinto, Sara A.S.L. Rosa, M. Raquel Aires-Barros, Ana M. Azevedo, Mara G. Freire; “Purification Of Monoclonal Antibodies From Cell Cultures Supernatants Using Aqueous Biphasic Systems With Ionic Liquids”. ESBES2016, European Symposium on Biochemical Engineering Sciences 2016, Dublin, Ireland, September 2016.

 

  • Emanuel V. Capela, Joćo H.P.M. Santos, Isabel Boal-Palheiros, Joćo A.P. Coutinho, Sónia P.M. Ventura, Mara G. Freire; “Aqueous Biphasic Systems For The Extraction Of Food Colorants: A Laboratory Experiment”. ESBES2016, European Symposium on Biochemical Engineering Sciences 2016, Dublin, Ireland, September 2016.

 

  • Emanuel V. Capela, Mafalda R. Almeida, Joćo A.P. Coutinho, Mara G. Freire; “Platform For The Purification Of Immunoglobulin Y (IgY) From Egg Yolk Using Aqueous Biphasic Systems”. ESBES2016, European Symposium on Biochemical Engineering Sciences 2016, Dublin, Ireland, September 2016.

 

  • Maria V. Quental, Emanuel V. Capela, Joćo A.P. Coutinho, Mara G. Freire; “Selective Separation Of Amino Acids Using Aqueous Biphasic Systems Composed Of Ionic Liquids”. ESBES2016, European Symposium on Biochemical Engineering Sciences 2016, Dublin, Ireland, September 2016.

 

  • Emanuel V. Capela, Ana Rita R. Teles, Ana Filipa M. Clįudio, Joćo A.P. Coutinho, Mara G. Freire; “Binary Mixtures of Ionic Liquids: Characterization of their Solvatochromic Parameters”. XII ENQF, 12th Portuguese Meeting on Physical Chemistry/1st Symposium on Computational Chemistry, Évora, Portugal, June 2016.

 

  • Emanuel V. Capela, Ana Rita R. Teles, Ana Filipa M. Clįudio, Kiki A. Kurnia, Joćo A.P. Coutinho, Mara G. Freire; “Hydrogen-bond Acidity and Basicity of Mixtures of Ionic Liquids: Experimental and COSMO-RS Approaches”. Jornadas CICECO 2016, Aveiro, Portugal, June 2016.

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Aqueous Biphasic Systems Composed of Ionic Liquids for the Selective Separation of Amino Acids”. Green Chemistry Session, 5th PYCheM & 1st EYCheM, 5th Portuguese Young Chemists Meeting and 1st European Young Chemists Meeting, Guimarćes, Portugal, April 2016.

 

  • Emanuel V. Capela, Mafalda R. Almeida, Joćo A.P. Coutinho, Mara G. Freire; “Purification of therapeutic Immunoglobulin Y (IgY) from egg yolk using Aqueous Biphasic Systems”. IV ENEQUI, IV National Chemistry Students Meeting, Oporto, Portugal, Marēo 2016.

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Selective extraction of amino acids by aqueous biphasic systems composed of ionic liquids”. IV ENEQUI, IV National Chemistry Students Meeting, Oporto, Portugal, Marēo 2016.

 

  • Emanuel V. Capela, Ana Filipa M. Clįudio, Joćo A.P. Coutinho, Mara G. Freire; “Hydrogen-bond Acidity and Basicity of Mixtures of Ionic Liquids: Experimental and COSMO-RS Approaches”. IV ENEQUI, IV National Chemistry Students Meeting, Oporto, Portugal, Marēo 2016.

 

  • Emanuel V. Capela, Ana Filipa M. Clįudio, Joćo A.P. Coutinho, Mara G. Freire; “Characterization of Mixtures of Ionic Liquids by their Solvatochromic Parameters”. 2nd EuGSC, 2nd EuCheMS Congress on Green and Sustainable Chemistry, Lisbon, Portugal, October 2015.

 

  • Emanuel V. Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Aqueous biphasic systems composed of ionic liquids: enhanced platforms for the selective separation of amino acids”. 2nd EuGSC, 2nd EuCheMS Congress on Green and Sustainable Chemistry, Lisbon, Portugal, October 2015.

 

  • Emanuel V. Capela, Mafalda R. Almeida, Joćo A.P. Coutinho, Mara G. Freire; “Purification of Immunoglobulin Y (IgY) using Aqueous Biphasic Systems”. 2nd EuGSC, 2nd EuCheMS Congress on Green and Sustainable Chemistry, Lisbon, Portugal, October 2015.

 

  • Emanuel Capela, Ana Filipa M. Clįudio, Joćo A.P. Coutinho, Mara G. Freire; “Hydrogen-bond Acidity and Basicity of Mixtures of Ionic Liquids: Experimental and COSMO-RS Approaches”. IMIL2015, Iberoamerican Meeting on Ionic Liquids, Madrid, Spain, July 2015.

 

  • Emanuel Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Aqueous biphasic systems composed of ionic liquids and amino acids as remarkable selective extraction approaches”. IMIL2015, Iberoamerican Meeting on Ionic Liquids, Madrid, Spain, July 2015.

 

  • Emanuel Capela, Joćo H.P.M. Santos, Sónia P.M. Ventura, Isabel Boal-Palheiros, Mara G. Freire; “Characterization of Aqueous Biphasic Systems Composed of Poly(ethyleneglycol) and Sodium Carbonate”. BPP2015, Biopartitioning & Purification Conference 2015, Vienna, Austria, June 2015.

 

  • Emanuel Capela, Maria V. Quental, Joćo A.P. Coutinho, Mara G. Freire; “Selective extraction of amino acids by aqueous biphasic systems composed of ionic liquids”. BPP2015, Biopartitioning & Purification Conference 2015, Vienna, Austria, June 2015.

 

  • Mafalda R. Almeida, Emanuel Capela, Helena Passos, Joćo A.P. Coutinho, Mara G. Freire; “Addition of ionic liquids to tune the phases’ polarities of polymer-salt aqueous biphasic systems”. ECTP2014, 20th European Conference on Thermophysical Properties, Oporto, Portugal, August - September 2014.

 

  • Mafalda R. Almeida, Emanuel Capela, Helena Passos, Joćo A.P. Coutinho, Mara G. Freire; “Tailoring the phases’ polarities of polymer-salt aqueous biphasic systems by the addition of ionic liquids”. ILSEPT, 2nd International Conference on Ionic Liquids in Separation and Purification Technology, Toronto, Canada, June - July 2014.
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