Vânia Mafalda de Oliveira André   
  Post-doc Fellowship  
   
  e-mail: vaniandre@tecnico.ulisboa.pt  
  department: Chemistry  
   
  supervisor: Teresa Duarte (IST)  
  co-supervisor: João Rocha  
  research group: G1 - Inorganic Functional Nanomaterials and Organic-Inorganic Hybrids
 
  direct url: http://www.ciceco.ua.pt/VaniaAndre  
     
Thesis
  • T2. Vânia André, Design of new active pharmaceutical ingredients (APIs) using co-crystallization and polymorphic screening, PhD thesis, 2011, Instituto Superior Técnico, Technical University of Lisbon.
  • T1. Vânia André, Estudos de co-cristalização e polimorfismo no controlo de qualidade de princípios farmaclogicamente activos, Master thesis, 2007, Instituto Superior Técnico, Technical University of Lisbon.
Patents
  • PT1. Vânia André, Luís Cunha-Silva, Pedro Paulo Santos, José Empis, M. Teresa Duarte, A new hydrated crystalline form of perindopril erbumine, methods for its preparation and its use in pharmaceutical preparations, 2012, WO2012044189-A1; PT105315-A1.
PAPERS IN INTERNATIONAL SCIENTIFIC PERIODICALS WITH REFEREES
  • PI32. Sílvia Quaresma, Vânia André, Alexandra Antunes, Luís Cunha-Silva, M. Teresa Duarte, Gabapentin coordination networks obtained by mechanochemistry: improved precursors to new bio-inspired materials for drug delivery and imaging, Crystal Growth & Design, 2013, ASAP (DOI: 10.1021/cg401187x).
  • PI31. Claudia Simao, Marta Mas-Torrent, Vânia André, M. Teresa Duarte, Simone Techert, Jaume Veciana, Concepció Rovira, Photodimerisation of tetrathiafulvalene derivatives bearing carboxylate and carboxylic acid substituents, CrystEngComm, 2013, accepted.
  • PI30. Roberta Paterna,  Vânia André, M. Teresa Duarte, Luis F. Veiros, Nuno R. Candeias, Pedro M. P. Gois,RingExpansion Reaction of Isatins with Ethyl Diazoacetate Catalyzed by Dirhodium (II)/DBU MetalOrganic System: En Route to Viridicatin Alkaloids, European Journal of Organic Chemistry, 2013, ASAP (DOI: 10.1002/ejoc.201300796).
  • PI29. Inês Martins, Marta Martins, Auguste Fernandes, Vânia André, M. Teresa Duarte, An insight into dapsone co-crystals: sulfones as participants in supramolecular interactions, CrystEngComm, 2013, 15(40), 8173-8179 (DOI: 10.1039/C3CE41323C).
  • PI28. Fátima C. Teixeira, Carla Lucas, M. João M. Curto, M. Neves, M. Teresa Duarte, Vânia André, António P.S. Teixeira, New 1-hydroxy-1,1-bisphosphonates derived from 1H-pyrazolo[3,4-b]pyridine: synthesis and characterization, Journal of the Brazilian Chemical Society, 2013, 24(8), 1295-1306 (DOI: 10.5935/0103-5053.20130164).
  • PI27. Vânia André, Inês Martins, Marta Martins, Sílvia Quaresma, M. Teresa Duarte, Transforming aspirin into novel molecular salts of salicylic acid, Structural Chemistry, 2013, 24(4), (DOI: 10.1007/s11224-013-0326-x). 
  • PI26. Fábio M. F. Santos,João N. Rosa, Vânia André, M. Teresa Duarte, Luís F. Veiros and Pedro M. P. Gois, NHC Catalysed Addition of Aldehydes to Diazo compounds: Stereoselective Synthesis of N-Acylhydrazones, Organic Letters, 2013, 15(7), 1760-1763 (DOI: 10.1021/ol400563w).
  • PI25. Luís M.T. Frija, Helga Garcia, Cátia Rodrigues, Isabel Martins, Nuno R. Candeias, Vânia André, Maria Teresa Duarte, Cristina Silva Pereira, Carlos A.M. Afonso,Short synthesis of the natural product 3β-hydroxy-labd-8(17)-en-15-oic acid via microbial transformation of labdanolic acid, Phytochemistry Letters, 2013, 6(2), 165-169 (DOI: 10.1016/j.phytol.2012.12.005).
  • PI24. Claudia Simão, Marta Mas-Torrent, Vânia André, M. Teresa Duarte, Jaume Veciana, Concepció Rovira, Photodimerisation product of a tetrathiafulvalene derivative as a component of a ternary molecular switch in solution and on surface, Chemical Science, 2013, 4, 307-310 (DOI: 10.1039/C2SC21134C).
  • PI23. Nuno R. Candeias, Carolina Carias, Luis F. R. Gomes, Vânia André, M. Teresa Duarte, Pedro M. P. Gois and Carlos A. M. Afonso, Asymmetric intramolecular C-H insertion of α-diazo acetamides in water by Dirhodium(II) catalysts derived from natural amino acids, Advanced Synthesis and Catalysis, 2012, 354(16), 2921-2927 (DOI: 10.1002/adsc.201200101).
  • PI22. Vânia André, M. Teresa Duarte, Revisiting paracetamol in a quest for new co-crystals, CrystEngComm, 2012, 14(15), 5005 - 5014 (DOI: 10.1039/c2ce25307k).
  • PI21. Vânia André, M. Teresa Duarte, Dario Braga, Fabrizia Grepioni, Polymorphic ammonium salts of the antibiotic 4-aminosalicylic acid, Crystal Growth & Design, 2012, 12, 3082-3090 (DOI: 10.1021/cg300284z).
  • PI20. Chinmay Maheshwari, Vânia André, Sreenivas Reddy, Lilly Roy,Teresa Duarte, Naír Rodríguez-Hornedo, Tailoring Aqueous Solubility of a Highly Soluble Compound via Co-crystallization: Effect of Coformer Ionization, pHmax, and Solute-Solvent Interactions, CrystEngComm, 2012, 14, 4801-4811  (DOI: 10.1039/C2CE06615G).
  • PI19. Francesco Montalbano, Nuno R. Candeias, Luís F. Veiros, Vânia André, M. Teresa Duarte, Maria R. Bronze, Rui Moreira, Pedro M. P. Gois, Four Component Assembly of Chiral N-B Heterocycles with a Natural Product Like Framework, Organic Letters, 2012, 14(4), 988-991 (DOI: 10.1021/ol203224n).
  • PI18. Sérgio M. Marques, Tiziano Tuccinardi, Adriano Martinelli, Salvatore Santamaria, Elisa Nuti, Armando Rossello, Vânia André and M. Amélia Santos, Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases: biological evaluation and binding mode prediction, Journal of Medicinal Chemistry, 2011, 54(24), 8298-8298 (DOI: 10.1021/jm200593b).
  • PI17. Vânia André, Luís Cunha-Silva, P. Paulo Santos, M. Teresa Duarte, First crystal structures of the antihypertensive drug Perindopril: a novel hydrated form and polymorphs alpha and beta, Crystal Growth & Design, 2011, 11, 3703–3706 (DOI: 10.1021/cg200430z).
  • PI16. Vânia André, Andrew Hardeman, Ivan Halasz, Robin S. Stein, Graham J. Jackson, David G. Reid, Melinda J. Duer, Caroline Curfs, M. Teresa Duarte , Tomislav Friščić, Mechanosynthesis of the metallodrug bismuth subsalicylate from Bi2O3 and the first structural characterisation of a bismuth salicylate, Angewandte Chemie International Edition, 2011, 50(34), 7858-7861 (DOI: 10.1002/anie.201103171).
  • PI15. Vânia André, Auguste Fernandes, P. Paulo Santos, M. Teresa Duarte, On the track of new multicomponent gabapentin crystal forms: synthon competition and pH stability, Crystal Growth & Design, 2011, 11, 2325–2334 (DOI:10.1021/cg200008z).
  • P114. Kamran T. Mahmudov, Maximilian N. Kopylovich, Konstantin V. Luzyanin, Archana Mizar, M. Fátima C. Guedes da Silva, Vânia André, Armando J. L. Pombeiro, Structural and thermal properties of three cyano-substituted azoderivatives of β-diketone, Journal of Molecular Structure, 2011, 992, 72-76 (DOI: 10.1016/j.molstruc.2011.02.045).
  • PI13. Alexandre F. Trindade, Vânia André, M. Teresa Duarte, Luís F. Veiros, Pedro M. P. Gois, Carlos A. M. Afonso, New dirhodium(II)-NHC catalysts for arylation of aldehydes, Tetrahedron, 2010, 66, 8494-8502 (DOI: 10.1016/j.tet.2010.08.050).
  • PI12. R.M.M. Sampaio , R.A. Timmers, N. Kocks, V. André, M. T. Duarte, E.D. van Hullebusch, F. Farges and P.N.L. Lens, Zn-Ni sulfide selective precipitation: the role of supersaturation, Separation and Purification Technology, 2010, 74 (1), 108-118 (DOI: 10.1016/j.seppur.2010.05.013).
  • PI11. A.P. Carapeto, A.P. Serro, B.M.F. Nunes, M.C.L. Martins, S. Todorovic, O.L. Eryilmaz, A. Erdemir, M. T. Duarte, V. André, R. Colaço, B. Saramago, Characterization of two DLC coatings for joint prosthesis: the role of albumin on the tribological behaviour, Surface and Coatings Technology, 2010, 204 (21-22), 3451-3458 (DOI: 10.1016/j.surfcoat.2010.04.022).
  • PI10. Raquel F. M. Frade, Nuno R. Candeias, Catarina M. M. Duarte, Vânia André, M. Teresa Duarte, Pedro M. P. Gois, Carlos A. Afonso, New Dirhodium Complex with Activity Towards Colorectal Cancer, Bioorganic & Medicinal Chemistry Letters, 2010, 20 (11), 3413-3415 (DOI: 10.1016/j.bmcl.2010.04.002).
  • PI9. Vânia André, M. Teresa Duarte, M. Matilde Marques, M. F. Minas da Piedade, An ester derivative of the reactive gabapentin, Journal of Molecular Structure, 2010, 973 (1-3), 173-179 (DOI: 10.1016/j.molstruc.2010.03.067).
  • PI8. Nuno R. Candeias, Pedro M.S.D. Cal, Vânia André, M. Teresa Duarte, Luís F. Veiros, Pedro M.P. Gois, Water as the reaction medium for multicomponent reactions based on boronic acids, Tetrahedron, 2010, 66, 2736-2745 (DOI: 10.1016/j.tet.2010.01.084).
  • PI7. Vânia André, Dario Braga, Fabrizia Grepioni, M. Teresa Duarte, New crystal forms of the antibiotic 4-aminosalicylic acid: solvates and molecular salts with dioxane, morpholine and piperazine, Crystal Growth and Design, 2009, 9, 5108-5116 (DOI: 10.1021/cg900495s).
  • PI6. Dario Braga, Fabrizia Grepioni, Vânia André, M. Teresa Duarte, Drug-containing coordination and hydrogen bonding networks obtained mechanochemically, CrystEngComm, 2009, 11, 2618 – 2621 (DOI: 10.1107/S0108270108026589).
  • PI5. Vânia André, M. Teresa Duarte, Alexandre F. Trindade, Pedro M. P. Góis, Carlos A. M. Afonso. A new solvate of bis(1,3-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene) Dirhodium Tetrakis(acetate), Acta Crystallographica, section C, 2008, C64, m345-m348 (DOI: 10.1107/S0108270108026589).
  • PI4. Dario Braga, Fabrizia Grepioni, Lucia Maini, Katia Rubini, Marco Polito, Roberto Brescello, Livius Cotarca, M. Teresa Duarte, Vânia André, M. Fátima M. Piedade. Polymorphic gabapentin: thermal behaviour, reactivity and interconversion of forms in solution and in the solid state, New Journal of Chemistry, 2008, 32, 1788-1795 (DOI: 10.1039/b809662g).
  • PI3. Alexandre F. Trindade, Pedro M. P. Gois, Luís F. Veiros, Vânia André, M. Teresa Duarte, Carlos A. M. Afonso, Stephen Caddick, F. Geoffrey N. Cloke, Axial Coordination of NHC Ligands on Di-rhodium(II) Complexes: Generation of a New Family of Catalysts, Journal of Organic Chemistry, 2008, 73, 4076-4086 (DOI: 10.1021/jo800087n).
  • PI2. Vânia André, Sónia Barroso, Ana M. Martins, M. Teresa Duarte, New conformer of 1,4,7-tris(p-toluenesulfonyl)-1,4,7-triazacyclononane, Acta Crystallographica, section C, 2007, 63(10), o594-0596 (DOI: 10.1107/S010827010703805X).
  • PI1. Pedro M. P. Gois, Alexandre F. Trindade, Luís F. Veiros, Vânia André, M. Teresa Duarte, Carlos A. M. Afonso, Stephen Caddick, F. Geoffrey N. Cloke, Tuning the Reactivity of Di-rhodium (II) Complexes with Axial NHC Ligands: The Arylation of Aldehydes, Angewandte Chemie International Edition, 2007, 46, 5750-5753 (DOI: 10.1002/anie.200700924).
Publications - book chapters

International publications:

  • BC2. Vânia André, Clara Gomes, M. Teresa Duarte, Mechanochemistry: a tool in the synthesis of catalysts, metallodrugs and metallophamacuticals, 2013, ICOMC Silver/Gold Jubilee Celebratory Book, in publication.
  • BC1. Vânia André and M. Teresa Duarte, Novel Challenges in Crystal Engineering: Polymorphs and New Crystal Forms of Active Pharmaceutical Ingredients, 2011, Current Trends in X-Ray Crystallography, ISBN: 978-953-307-754-3, InTech (over 4000 downloads in August 2013)

 

National publications:

  • BCN3. Clementina Teixeira, Marta Smith, Gonçalo Santos, Mafalda Lancinha, Carolina Belchior, João Vilhena Moreira, Ana Sofia Borrego, Vera Silva, Vânia André, Experiências com Azoto Líquido e Neve Carbónica (Gelo Seco), Laboratórios Abertos 2013, 2013, Lemos, M.A., Gomes Azevedo, C., eds., DEQB - Publicações, in publication.
  • BCN2. Clementina Teixeira, Vânia André, Nuno Lourenço, Sílvia Chaves, Marta Smith, Mafalda Lancinha, Carolina Belchior, Show de Azoto: O Azoto Mega Show! Experiências com azoto líquido, neve carbónica e bolas de sabão, Laboratórios Abertos 2011, 2011, Lemos, M.A., Gomes Azevedo, C., eds., DEQB - Publicações, ISBN: 978-989-96933-2-6, 2011, p.86-94.
  • BCN1. Clementina Teixeira, Vânia André, CO2, o Mau da Fita - Experiências com neve carbónica, bolas de sabão e azoto líquido, Livro dos Laboratorios Abertos Junior 2011, 2011, Lemos, M.A., Gomes Azevedo, C., eds., DEQB - Publicações, ISBN: 978-989-96933-1-9, 31-32.
PAPERS IN NATIONAL PERIODICALS WITH REFEREES
  • PN3. Vânia André, Novas formas para velhos fármacos, Revista da Sociedade Portuguesa de Química, 2012, 127, 51-55.
  • PN2. Clementina Teixeira, Vânia André, Sílvia Chaves, Hermínio Diogo, Nuno Lourenço, Filipe Menezes, Água quase tudo... e cloreto de sódio: purificação do cloreto de sódio, Revista da Sociedade Portuguesa de Química, 2007, 106, 18-29.
  • PN1. Clementina Teixeira, Vânia André, Nuno Lourenço, Maria José Rodrigues, Crescimento de cristais por nucleação heterogénea: “on the rocks” revisited, Ciência e Tecnologia dos Materiais, 2007, 19(1/2), 66-77.




 
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