Ana Maria Pissarra Coelho Gil
  Associate Professor with Aggregation  
   
  phone: 234 370 707  
  extension: 33511  
  e-mail: agil@ua.pt  
  departament: Chemistry  
  office: 29.2.42  
   
  research line: L3 - Sustainability and Health
 
  research group: G5 - Biomedical and Biomimetic Materials
 
isi web of knowledgeSM search factor: Gil, AM  
  direct url: http://www.ciceco.ua.pt/AnaGil  
     
Short CV
Present position: Associate Professor "com agregação", Department of Chemistry , University of Aveiro since January 2007
Previous positions:
1998-2007 Associate Professor, Department of Chemistry , University of Aveiro
1993-98 Lecturer, Department of Chemistry , University of Aveiro;
1990-93 Assistente, Department of Chemistry , University of Aveiro;
1988-1990 Assistente Estagiaria, Department of Chemistry , University of Aveiro;
1987-1988:Assistente Estagiaria, School of Biotechnology, Portuguese Catholic University, Oporto.

Academic degrees:
1992: Doctorate in Chemistry, University of East Anglia, U.K., with a thesis titled "Spectroscopic Studies of Proteins in the Solid State";
1990: Provas de Aptidao Pedagogica e Capacidade Cientifica on "Gelification of polysaccharides: study of the effect of ions" and "Study of sulphated polysaccharides by FTIR";
1987: Licenciatura in Chemistry, Faculty of Sciences and Technology, University of Coimbra, Portugal, completed in October 1987 with mark 17/20.
Scientific Interests
Scientific interests in approximate evolutive order:
Structural characterisation of purified cereal proteins for the understanding of their functional properties;
Structural studies of cork and othet lignocellulosic materials;
Structural and dynamic studies of mono- and oligosaccharides in the solid state;
Development of rheo-NMR techniques for the interpretation of rheological properties at the molecular level;
Structural and synamics of polysaccharide gels;
Stucy of the biochemical compositional changes in fruits and fruit juices;
Development of spectroscopy-based methods for the routine quality control of products and processes in the food industry (brewing industry and beverages industry);
Analysis of human biofluids and biological tissues for the biochemical characterisation and early diagnosis of diseases;
Development of new biomaterials and their ex-vivo and in-vivo testing and evaluation for different uses.
Present Research Group

Summary on January 2015: 5 Postdocs supervised and 2 ongoing; 7 PhD theses terminated (6 as supervisor, 1 as co-supervisor) and 5 ongoing; 13 Master theses terminated and 2 ongoing; Other researchers: 5 completed and 1 ongoing.

Research group January 2015:
2. Postdoc supervision on "Novel bioregeneration materials tested by cell metabolomics", Paula Marinho, from January 2014.
1. Postdoc co-supervision on "New piezoelectric materials evaluated through a metabolomics approach", Marisa Costa, from Sep 2013.

*****
5. PhD co- supervision on "Age-related macular degeneration – can metabolomic profile distinguish progressors?", Inês Laíns, Universidade de Aveiro and University of Coimbra, from June 2014.
4. PhD co- supervision on "O papel do intestino no desenvolvimento da esteatose hepática induzida pela frutose", João Silva, FCT SFRH/BD/90250/2012, from Sep 2013.
3. PhD co- supervision on "Study of renal cancer through metabolomics", Márcia Monteiro, FCT SFRH/BD/805 18/2011, from Apr 2012.
2. PhD supervision on "Análise metabonómica de plasma de mulheres grávidas para identificação de indicadores lipídicos de doenças da mãe e do feto", Joana Pinto FCT SFRH/BD/73343/2010, from Apr 2011.
1. PhD supervision on “Suportes implantáveis para quimioterapia localizada do osteossarcoma", Inês Lamego, FCT SFRH/BD/63916/2009, from Jan 2010.

*****
2. Master on "Lipidomics for determination of early markers of trisomy 21", Ana Sofia Domingues, from Sep 2014.
1. Master/Estagio empresarial on "Food safety and water quality", Raquel Barreira, with YourLab Aveiro, from Sep 2014.

*****
1. Research grantee (8 months) within project on “Effects of environmental hazards of the Estarreja region on pregnancy metabolism”, funded by Observatório - OHMI Estarreja, Daniela Duarte, from Sep 2014.

Previous supervisions:

5.Postdoc supervision on “Development of new biocomposites”, Dr Ana Luísa Silva, Universidade de Aveiro (Chemistry and Ceramics departments), FCTSFRH/BPD/39105/2007 Jan 2008-Dec2009.
4. Postdoc on “Espectroscopia de RMN e LC-NMR/MS para a análise de bioflúidos”, Dr. Iola Melissa Duarte, Universidade de Aveiro(Imperial College London, Funded by FCT SFRH/BPD/11516/2002, Apr2003-Jul 2006.
3.Postdoc supervision on “Characterisation of carbohydrates in the solid state", Dr. Loic Hilliou, Universidade de Aveiro, Funded by Universidade de Aveiro (postdoc grant), Jan 2003-Jan 2004.
2.Postdoc supervision on “Chemical modification of polysaccharides for the dontrol and optimisation of their functional properties:spectroscopic and rheological studies”, Doutora Matilde Vieira, Universidade de Aveiro, FCT SFRH/BPD/5520/2001, Nov 2001-Nov 2003.
1.Postdoc supervision on “Structural studies of carbohydrates in the solid state”, Doutora Enrica Alberti, Universidade de Aveiro, funded by FCT SFRH/BPD/1595/2000, Nov 2000-Nov 2001.

*****
7. PhD supervision on “Metabolomics of urine and plasma for pregnancy monitoring and prediction of disorders of the mother, foetus and newborn ", Sílvia Diaz FCT SFRH/BD/64159/2009, from Jan 2010.
6. PhD supervision on “Novos métodos de diagnóstico pré-natal com base em espectroscopia de
RMN”, Gonçalo Graça SFRH/BD/41869/2007, Jan 2008-Apr 2013.
5. PhD supervision on “Desenvolvimento de métodos de Espectroscopia de Ressonância
Magnética Nuclear (RMN) para o controlo da qualidade da cerveja e seu processo de fabrico”,
João Aleixo Rodrigues SFRH/BD/31056/2006, Oct 2006-Nov 2011.
4. PhD co-supervision on “Influência das pentosanas nas propriedades funcionais do glúten e do
amido de trigo”, Dora M. Santos, Universidade de Aveiro, FCT PRAXIS XXI / BD / 14770 /
96, Oct 1998 - Mar 2005.
3. PhD supervision on “Aplicação de espectroscopia de Ressonância Magnética Nuclear e
espectroscopia vibracional para a caracterização de frutos e bebidas”, Iola M. F. Duarte,
Universidade de Aveiro, FCT PRAXIS XXI/BD/15666/ 98, Oct 1998 – Apr 2003.
2. PhD supervision on "Estudos de ressonância magnética de proteínas de cereais e sistemas
modelo” Enrica Alberti, Universidade de Aveiro, Comunidade Europeia CT951170, Oct 1996
- Oct 2000.
1. PhD supervision on "Estudos estruturais da cortiça e seus constituintes: aplicação de técnicas
espectroscópicas e análise química", Marta Helga Lopes, Universidade de Aveiro, PRAXIS XXI BD/3765/94, Oct 1995 – Nov 2000.

*****
13. Master on "Lipidomics of plasma for maternal diseases research", Lara Monteiro, from Sep 2013.
12. Master/Estágio empresarial on "Food safety strategies on ready-made meals", Bruno Henriques, with YourLab Aveiro, from Sep 2013.
11. Master co-supervision on “Contaminação microbiológica de alimentos: o caso particular da iE. Coli.”, em co-supervisão com YourLAB, VLM Consultores, Aveiro, Diana Almeida 2012/2013.
10. Master cosupervision on “Implementação de HACCP  em entrepostos alimentares seleccionados”, co-supervision with SONAE, Joana Morais Pinto, Universidade de Aveiro, 2011/2012.
9.Master cosupervision on “Impacto de contaminações alimentares em alimentos prontos a consumir”, co-supervision with VLM Consultores, Daniela Framegas, 2011/2012.
8. Master supervision on “Efeitos de agentes de stress ambiental sobre o metaboloma da alface”, Patrícia Figueiredo, Universidade de Aveiro, 2010/2011.
7. Master supervision on “Implementação da norma NP 4397 e da norma NP EN ISO 22000:2005 na Empresa Virgílio C. Moreira Lda.”, Ana Filipa Marques, Universidade de Aveiro, 2010/2011.
6. Master supervision on “Implementação dos sistemas de segurança alimentar ISO 22000 e HACCP”, co-supervision with VLM Consultores, Teresa Fonseca, Universidade de Aveiro, 2010/2011.
5. Master supervision on “Análise metabonómica de plasma de mulheres grávidas para identificação de indicadores lipídicos de doenças da mãe e do feto", Joana Pinto, Universidade de Aveiro, Oct2008-Jul2010.
4. Master supervision on “Análise da funcionalidade e estrutura molecular de farinhas”, Andreia Dias, Universidade de Aveiro, 2002-2008.
3. Master co-supervision on “Efeito da massa molecular de um polissacarídeo na gelificação de proteínas”, Sónia Regina Rodrigues Mota Monteiro, Universidade de Aveiro,2002–2006.
2. Master supervision on “Análise espectroscópica (RMN E FTIR) e multivariada de cerveja e vinhos”, Cláudia Almeida, Universidade de Aveiro, 2002–2006.
1. Master co-supervision on "Study of the resistence of three red wine varieties to the Botrytis-cinerea fungus) -development of methods for the quantification of resvertrol”, Elsa M. G. Oliveira, Universidade de Aveiro, 1995-1999.
*****
5. Researcher working on “The role of the intestine in promoting the lipogenic effects of fructose”, Sara Pereira, funded by Fundação para a Ciência e Tecnologia (PTDC/SAU-MET/111398/2009), Set 2012-Set 2013.
4. Researcher working on "“Estudo do efeito de malformações fetais na composição do líquido amniótico por espectroscopia de infravermelho com transformadas de Fourier (FT-IR)”, Ana Sofia Pereira Moreira, Bolsa de Integração na Investigação, Fundação para a Ciência e Tecnologia, 2008-2009.  
3. Researcher working on "Osteocarsoma cell metabolism and metabolic effects of new drugs", Joana Marques, Universidade de Aveiro, Funded by project FCT PTDC/SAU-BEB/66896/2006.
2. Researcher working on “Mould proteome regulation by substrate bioavailability: depolymerising enzymes likely to alter biopolymer nanostructure.”, Helga Garcia, Universidade de Aveiro, Funded by project FCT POCTI/QUI/56229/2004, Jan 2006-Jan 2008.
1. Researcher working on “Solid state NMR of carbohydrates”, Andreia Rosa, Universidade de Aveiro, funded by, Fevereiro 2003 – Nov 2003.

Main present collaborators
Faculty of Medicine, Imperial College of Science, London, UK;
Department of Chemistry, University of Warwick, UK
Laboratoire de Chimie, Ecole Normale Superieure de Lyon (ENSL)
Bruker Biospin GmbH, Germany
Faculdade de Medicina da Universidade de Coimbra Centro de Neurociencias e Biologia Celular-CNC, Universidade de Coimbra, Portugal
Maternidade Bissaya Barreto, Coimbra, Portugal
Centro Hospitalar de Gaia, Portugal
University of Turku, Finland
Teaching Activity
Has taught the following Licenciatura courses:
General Chemistry I and II (lab and exercise classes) / ESB,
Thermodynamics (exercise classes) / ESB,
Structure and Properties of Matter (exercise classes) / UA,
Water Chemistry (exercise classes) / UA,
Chemistry Laboratories (lab classes) / UA,
Food Chemistry II (lab classes/ UA,
Bio-organics (lab classes) / UA,
Food Analysis (theory and lab classes) / UA,
Chemistry I (theory and exercise classes) / UA,
Food Quality and Safet (theory classes), UA
Biochemistry I (theory and exercise classes) UA
Fundaments of Biocehmistry (theory and exercise classes), UA
Biochemistry (theory) UA

Has taught the following Master degree courses:
Food safety and quality (3h theory, Master in Food Biochemistry),
Colloid Chemistry (6 h theory / Master in Chemistry of Natural Products and Foodstuffs, UA,
Solid state NMR (4h theory) / Master in Chemistry of Natural Products and Foodstuffs, UA,
Solid state NMR (2h theory) / Master in Materials Engineering, UA,
Advanced Analytical Techniques for Food Analysis (22 horas), Master in Chemistry of Natural Products and Foodstuffs, UA.
Present projects

Projects in May 2010:
2007-2010: Principal investigator in project on "Estudo metabonómico de desordens da grávida e do feto por espectroscopia de Ressonância Magnética Nuclear (RMN): caracterização bioquímica e métodos de diagnóstico" funded byFundação para a Ciência e Tecnologia(PTDC/QUI/66523/2006.
2008-2011: Participant in project on “Metabolic profiling and biochemical differentiation of human lung tumours by Nuclear Magnetic Resonance (NMR) methods” funded by Fundação para a Ciência e Tecnologia.
2008-2011: Participant in project on "Nanochemistry of magnetic/luminescent composites for in vitro medical diagnosis applications" funded by Fundação para a Ciência e Tecnologia (PTDC/QUI/67712/2006).
2007-2010: Participant in Project on "Implantable scaffolds for local osteo-sarcoma chemotherapy", funded by “Fundação para a Ciência e Tecnologia”, PTDC/SAU-BEB/66896/2006.

Selected Publications
SCI papers in last 5 years: 1. Duarte, I.F., Goodfellow, B.J., Delgadillo, I., Gil, A.M. “Characterisation of mango juice by high resolution NMR, hyphenated NMR and diffusion ordered spectroscopy”, Spectroscopy Letters, 38 (3), 319-342, 2005.
2. Nilsson, M.L. Gil, A.M., Delgadillo, I., Morris, G.A., “Improving pulse sequences for 3D DOSY: COSY-IDOSY”, Chemical Communications, 13, 1737 – 1739, 2005.
3. Gil, A.M., Vieira, M. “A solid state NMR study of Locust bean gum galactomannan and Konjac glucomannan gels”, Carbohydrate Polymers, 60(4), 439-448, 2005.
4. Duarte, Iola F., Stanley, Elizabeth G., Holmes, Elaine, Lindon, John C., Gil, Ana M., Tang, Huiru, Ferdinand, Roxanne, McKee, Claire Gavaghan, Nicholson, Jeremy K., Vilca-Melendez, Hector, Heaton Nigel, Murphy, Gerard M., “High Resolution Magic Angle Spinning 1H NMR Spectroscopy for Rapid Metabolic Assessment of Human Liver Transplants”, Analytical Chemistry, 77, 5570-5578, 2005.
5. Yates, J.R., Pham, T.N., Pickard, C.J., Mauri, F., Amado, A.M., Gil, A.M., Brown, S.P., “An investigation of weak CH center dot center dot center dot O hydrogen bonds in maltose anomers by a combination of calculation and experimental solid-state NMR spectroscopy”, Journal of American Chemical Society, 127 (29), 10216-10220, 2005.
6. Duarte, I.F., Delgadillo, I., Gil, A.M., “Study of Natural Mango Juice Spoilage and Microbial Contamination with Penicillium expansum by High Resolution NMR Spectroscopy”, Food Chemistry, 96 (2), 313-324, 2006.
7. Almeida, C., Duarte, I.F., Barros, A., Rodrigues, J., Spraul, M., Gil, A.M., “The composition of beer by 1H NMR spectroscopy: the effects of brewing site and date of production “, Journal of Agricultural and Food Chemistry,54, 700-706, 2006.
8. Li, W., Dobraszczyk, B.J., Dias, A., Gil, A. M., “The polymer conformation structure of wheat proteins and gluten subfractions revealed by FTIR-ATR”, Cereal Chemistry, 83 (4), 407-410, 2006.
9. Duarte,I.F., Goodfellow,B.J., Barros, A., Jones, J.G., Barosa, C., Diogo, L., Garcia, P., Gil, A.M., "Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high resolution 1H NMR spectroscopy", NMR in Biomedicine, 20,401-412, 2007.
10.Bertram, H.C., Duarte, I.F., Gil, A.M., Bach Knudsen K.E., Lærke, H.N., “Metabolic Profiling of liver from hypercholesterolemic pigs fed rye or wheat fiber and from normal pigs. High resolution magic angle spinning 1H NMR spectroscopic study”, Analytical Chemistry, 79, 168-175, 2007.
11. Carvalho, J.M., Gonçalves, C., Gil, A.M., Gama, F.M., “Production and Characterization of a New Dextrin Based Hydrogel”, Polymer, 3050-3059, 43(7),2007.
12. Lopes da Silva, J.A., Santos, D.M.J., Freitas, A., Brites, C., Gil, A.M. “A Rheological and Nuclear Magnetic Resonance (NMR) study of the hydration and heating of undeveloped wheat doughs”, Journal of Agricultural and Food Chemistry, 5636-5644, 55,2007.
13. Daniel-da-Silva,A., Lopes,A.B., Gil,A.M., Correia,R.N.,"Synthesis and characterisation of porous kappa-carrageenan/calcium phosphate nanocomposite scaffolds", Journal of Materials Science, 8581-8591, 42(20),2007.
14. Daniel-da-Silva,A., Trindade,T., Goodfellow, B.,Costa, B.F.O.,Correia, R.N., Gil, A.M., "In situ Synthesis of Magnetite Nanoparticles in Carrageenan Gels", Biomacromolecules, 2350-2357, 8(8),2007.
15. Graça, G., Duarte, I.F., Goodfellow, B.J., Barros, A.S., Carreira, I.M., Couceiro, A.B., Spraul, M., Gil, A.M., “The potential of NMR spectroscopy for the study of human amniotic fluid”, Analytical Chemistry, 8367-8375, 79(21),2007.
16. Daniel-da-Silva,A., Pinto, F., Lopes da Silva, J.A., Trindade,T., Goodfellow, B., Gil, A.M., “Rheological behavior of thermoreversible -carrageenan/nanosilica gels”, Journal of Colloidal and Interface Science, 575-581,320(2), 2008.
17. Daniel-da-Silva,A., Lóio, R., Lopes da Silva, J.A., Trindade,T., Goodfellow, B., Gil, A.M., “Effects of Magnetite Nanoparticles on the Thermo-rheological Properties of Carrageenan Hydrogels”, Journal of Colloidal and Interface Science, 205-211, 324,2008.
18. Garcia, H., Barros, A.S., Gonçalves, C., Gama, F.M., Gil, A.M., “Characterisation of dextrin hydrogels by FTIR spectroscopy and solid state NMR spectroscopy”, European Polymer Journal,2318-2329, 44/7,2008.
19. Graca, G., Duarte, I. F., Goodfellow, B. J., Carreira, I. M., Couceiro, A. B., Domingues, M. R., Spraul, M., Tseng, L.-H., Gil, A. M. “Metabolic profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy”, Analytical Chemistry, 6085-6092, 80(15),2008.
20. Duarte, Iola F., Legido-Quigley,.Cristina, Parker, David A., Swann, Jonathan R., Spraul, Manfred, Braumann,Ulrich, Gil, Ana M., Holmes, Elaine, Nicholson, Jeremy K. Murphy, Gerard M., Vilca-Melendez, Hector, Heaton, Nigel, Lindon, John C., “Identification of metabolites in human hepatic bile using 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS.”, Molecular Systems, 180-190, 5, 2009.
21. Carvalho, Pedro J., Alvarez, Víctor H., Schröder, Bernd, Gil, Ana M., Marrucho, Isabel M., Aznar, Martín, Santos, Luís M. N. B. F., Coutinho, João A. P., “Specific Solvation Interactions of CO2 on Acetate and Trifluoroacetate Imidazolium Based Ionic Liquids at High Pressures”, Journal of Physical Chemistry B, 113, 6803-6812, 2009.
22. Duarte, I.F., Marques, J., Ladeirinha, A.F., Rocha, C., Lamego, KI., Calheiros, R., Silva, T.M., Marques, M.P.M., Melo, J.B., Carreira, I.M., Gil, A.M., “Analytical approaches towards successful human cell metabolome studies by NMR spectroscopy”, Analytical Chemistry, 81, 5023-5032, 2009.
23. Graça, G., Duarte, I.F., Barros, A.S., Goodfellow, B.J., Diaz, S., Carreira, I.M., Couceiro, A.B., Galhano, E., Gil, A.M., “1H NMR Based Metabonomics of Human Amniotic Fluid for the Metabolic Characterization of Foetus Malformations”, Journal of Proteome Research, 8, 4144-4150, 2009.
24. Daniel-da-Silva, A.L., Fateixa, S., Guiomar, A.J., Costa, B.F.P., Silva, N.J.O., Trindade, T., Goodfellow, B.J., Gil, A.M., Biofunctionalized magnetic hydrogel nanospheres of magnetite and kapa-carrageenan, Nanotechnology, 20, Article Number: 355602, 2009.
25. Rocha, C, Barros, A.S., Gil, A.M., Goodfellow, B.J., Humpfer, E., Spraul,M., Carreira, I.M., Melo, J.B., Bernardo, J., Gomes, A:, Sousa,V., Carvalho, L., Duarte, I.F., “Metabolic Profiling of Human Lung Cancer Tissue by 1H High Resolution Magic Angle Spinning (HRMAS) NMR Spectroscopy”, Journal of Proteome Research, 81, 5023-5032, 2009.
26. Erny, G.L., Rodrigues, J.E.A., Gil, A.M., Barros, A.S., Esteves, V.I., Esteves, V.I., “Analysis of Non-Aromatic Organic Acids in Beer by CE and Direct Detection Mode with Diode Array Detection”, Chromatographia, 70 (11-12), 1737-1742, 2009.
27. Duarte, I.F., Lamego, I., Rocha, C., Gil, A.M., “NMR metabonomics for mammalian cell metabolism studies”, Bioanalysis, 1(9), 1597-1614, 2009.
28. Amy L. Webber, Bénédicte Elena, John M. Griffin, Jonathan R. Yates, Tran N. Pham, Francesco Mauri, Chris J. Pickard, Ana M. Gil, Robin Stein, Anne Lesage, Lyndon Emsley and Steven P. Brown, “Complete 1H resonance assignment of β-maltose from 1H–1H DQ-SQ CRAMPS and 1H (DQ-DUMBO)–13C SQ refocused INEPT 2D solid-state NMR spectra and first principles GIPAW calculations”, Phys. Chem. Chem. Phys., 2010, DOI: 10.1039/c001290d


ongoing scientific supervisions


Projects




























 
Events
Sponsors

1suponsers_list_ciceco.jpg