Emanuel V. Capela is currently a PhD student/researcher at the research group "Process and Product Applied Thermodynamics" (PATh), CICECO - Aveiro Institute of Materials, University of Aveiro, Portugal in collaboration with Institute for Bioengeneering and Biosciences (iBB), Department of Bioengeneering, Instituto Superior Técnico, University of Lisbon, Portugal. His research activities are mainly focused in the production of monoclonal antibodies (mAbs) by mammalian cell technology and in the design of integrated downstream bioprocesses, for the selective extraction and purification of mAbs directly from the complex medium, envisaging the process integration and intensification. Moreover, he has been working with a new class of solvents, ionic liquids, where his scientific interest devoted to these compounds includes the characterization of their properties and the evaluation of their potential in the establishment of extractive platforms for value-added compounds, in particular for biopharmaceuticals. Born on 24 of June of 1993 at Porto, Portugal, obtained his BSc degree in Biochemistry from University of Aveiro, Portugal, in 2014, and his MSc degree in Biochemistry - Biomolecular Methods from the same institution in 2016.
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2017 - ongoing | PhD in Chemical Engineering, specialization in Bioengineering | University of Aveiro and Instituto Superior Técnico - University of Lisbon | Thesis title: "Innovative platforms for the downstream processing of antibody-based biopharmaceuticals", supervised by Dr. Mara G. Freire (UA) and co-supervised by Dr. Ana M. Azevedo (IST) and Prof. João A.P. Coutinho (UA).
2014 - 2016 | MSc in Biochemistry, specialization in Biomolecular Methods | University of Aveiro | Thesis title:"Production and purification of antibodies using aqueous biphasic systems composed of ionic liquids as adjuvants", supervised by Dr. Mara G. Freire (UA) and co-supervised by Dr. Ana M. Azevedo (IST) and Prof. M. Raquel Aires-Barros (IST).
2011 - 2014 | BSc in Biochemistry | University of Aveiro | Project title: "Purification of antibodies using aqueous biphasic systems", supervised by Dr. Mara G. Freire (UA) and co-supervised by Master Mafalda R. Almeida (UA).
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2018 | Guest Researcher | Sustainable Research Technology (SPT) group, Faculty of Science and Technology (TNW), University of Twente, The Netherlands.
2016 - 2017 | Research Assistant | Department of Bioengineering, Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), University of Lisbon, Portugal.
2015 - 2016 | MSc Researcher | Department of Bioengineering, Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), University of Lisbon, Portugal.
2014 | BSc Researcher | Department of Chemistry, CICECO – Aveiro Institute of Materials, University of Aveiro, Portugal.
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Insights on the laccase extraction and activity in ionic-liquid-based aqueous biphasic systemsCapela, EV; Valente, AI; Nunes, JCF; Magalhaes, FF; Rodriguez, O; Soto, A; Freire, MG; Tavares, APM 2020, SEPARATION AND PURIFICATION TECHNOLOGY, 248,
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Sustainable strategies based on glycine-betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatantsCapela, EV; Santiago, AE; Rufino, AFCS; Tavares, APM; Pereira, MM; Mohamadou, A; Aires-Barros, MR; Coutinho, JAP; Azevedo, AM; Freire, MG 2019, GREEN CHEMISTRY, 21, 20, 5671-5682.
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A simple approach for the determination and characterization of ternary phase diagrams of aqueous two-phase systems composed of water, polyethylene glycol and sodium carbonate.Capela, Emanuel V; Santos, Joao H P M; Boal-Palheiros, Isabel; Coutinho, Joao A P; Ventura, Sonia P M; Freire, Mara G 2019, CHEMICAL ENGINEERING EDUCATION, 53, 2, 112-120.
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LYTAG-driven purification strategies for monoclonal antibodies using quaternary amine ligands as affinity matricesCampos-Pinto, I; Capela, EV; Silva-Santos, AR; Rodriguez, MA; Gavara, PR; Fernandez-Lahore, M; Aires-Barros, MR; Azevedo, AM 2018, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 93, 7, 1966-1974.
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Mechanisms ruling the partition of solutes in ionic-liquid-based aqueous biphasic systems - the multiple effects of ionic liquidsPassos, H; Dinis, TBV; Capela, EV; Quental, MV; Gomes, J; Resende, J; Madeira, PP; Freire, MG; Coutinho, JAP 2018, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 20, 13, 8411-8422.
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Aqueous biphasic systems in the separation of food colorantsSantos, JHPM; Capela, EV; Boal-Palheiros, I; Coutinho, JAP; Freire, MG; Ventura, SPM 2018, BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 46, 4, 390-397.
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Effective separation of aromatic and aliphatic amino acid mixtures using ionic-liquid-based aqueous biphasic systemsCapela, EV; Quental, MV; Domingues, P; Coutinho, JAP; Freire, MG 2017, GREEN CHEMISTRY, 19, 8, 1850-1854.
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Solvatochromic parameters of deep eutectic solvents formed by ammonium-based salts and carboxylic acidsTeles, ARR; Capela, EV; Carmo, RS; Coutinho, JAP; Silvestre, AJD; Freire, MG 2017, FLUID PHASE EQUILIBRIA, 448, 15-21.
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Good's buffer ionic liquids as relevant phase-forming components of self-buffered aqueous biphasic systemsTaha, M; Quental, MV; Silva, FAE; Capela, EV; Freire, MG; Ventura, SPM; Coutinho, JAP 2017, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 92, 9, 2287-2299.
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Solubility and solvation of monosaccharides in ionic liquidsTeles, ARR; Dinis, TBV; Capela, EV; Santos, LMNBF; Pinho, SP; Freire, MG; Coutinho, JAP 2016, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 18, 29, 19722-19730.
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Application of Ionic Liquids in Separation and Fractionation ProcessesEmanuel V. Capela, João A.P. Coutinho, Mara G. Freire In Buxing Han and Tianbin Wu (Eds.), Green Chemistry and Chemical Engineering 2019, 637-665. New York, NY: Springer.
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Application of Ionic Liquids in Separation and Fractionation ProcessesEmanuel V. Capela, João A.P. Coutinho, Mara G. Freire In Robert A. Meyers (Eds.), Encyclopedia of Sustainability Science and Technology 2018, 1-29. New York, USA: Springer.
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Monoclonal Antibodies – Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic AgentsEmanuel V. Capela, M. Raquel Aires-Barros, Mara G. Freire, Ana M. Azevedo In Atta-ur-Rahman (Eds.), Frontiers in Clinical Drug Research-Anti Infectives 2017, 142-203. Sharjah, UAE: Bentham Science.
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