Publications
What is better to enhance the solubility of hydrophobic compounds in aqueous solutions: eutectic solvents or ionic liquids?
                
				
                    Ferreira, O; Silva, LP; Almeida, HHS; Benfica, J; Abranches, DO; Pinho, SP; Coutinho, JAP
				
				
				
                    2024, RSC SUSTAINABILITY, 2, 12, 4052-4060.				
                					
					
						ISBN:
                        2753-8125
					
                    
			
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Exploring the impact of sodium salts on hydrotropic solubilization
                
				
                    Benfica, J; Martins, AC; Peréz-Sanchéz, G; Schaeffer, N; Coutinho, JAP
				
				
				
                    2023, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25, 38, 26327-26340.				
                
			
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Assessing the hydrotropic effect in the presence of electrolytes: competition between solute salting-out and salt-induced hydrotrope aggregation
                
				
                    Martins, AC; Benfica, J; Perez-Sanchez, G; Shimizu, S; Sintra, TE; Schaeffer, N; Coutinho, JAP
				
				
				
                    2022, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 24, 36, 21645-21654.				
                
			
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The impact of the counterion in the performance of ionic hydrotropes
                
				
                    Dinis O. Abranches, Jordana Benfica, Bruna P. Soares, Ana M. Ferreira, Tânia E. Sintra, Seishi Shimizu, João A. P. Coutinho
				
				
				
                    2021, Chemical Communications, 57, 2951-2954 .				
                
			
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Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation
                
				
                    Sintra, TE; Abranches, DO; Benfica, J; Soares, BP; Ventura, SPM; Coutinho, JAP
				
				
				
                    2021, EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 164, 86-92.				
                					
					
						ISBN:
                        1873-3441
					
                    
			
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Aqueous solutions of organic acids as effective solvents for levodopa extraction from Mucuna pruriens seeds
                
				
                    Benfica, J; Morais, ES; Miranda, JS; Freire, MG; de Sousa, RDS; Coutinho, JAP
				
				
				
                    2021, SEPARATION AND PURIFICATION TECHNOLOGY, 274.				
                					
					
						ISBN:
                        1873-3794
					
                    
			
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Enhanced Extraction of Levodopa from Mucuna pruriens Seeds Using Aqueous Solutions of Eutectic Solvents
                
				
                    Benfica, J; Miranda, JS; Morais, ES; Freire, MG; Coutinho, JAP; de Sousa, RDS
				
				
				
                    2020, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 8, 17, 6682-6689.				
                
			
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Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute
                
				
                    Abranches, DO; Benfica, J; Soares, BP; Leal-Duaso, A; Sintra, TE; Pires, E; Pinho, SP; Shimizu, S; Coutinho, JAP
				
				
				
                    2020, CHEMICAL COMMUNICATIONS, 56, 52, 7143-7146.				
                					
					
						ISBN:
                        1364-548X
					
                    
			
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Solubility Enhancement of Hydrophobic Substances in Water/Cyrene Mixtures: A Computational Study
                
				
                    Abranches, DO; Benfica, J; Shimizu, S; Coutinho, JAP
				
				
				
                    2020, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 59, 40, 18247-18253.				
                
			
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The Perspective of Cooperative Hydrotropy on the Solubility in Aqueous Solutions of Cyrene
                
				
                    Abranches, DO; Benfica, J; Shimizu, S; Coutinho, JAP
				
				
				
                    2020, Industrial & Engineering Chemistry Research, 59, 41, 18649-18658.				
                
			
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