29 September 2026
On the 24th September 2026, Françoise Kleinsorgen introduced her work at the 33rd Annual Congress of the European Association for Osseointegration (EAO), that occurred at the Lisbon Congress Centre. The work was included in the basic research category of one of the main international scientific meetings in oral implantology. The abstract of the work was published in the congress supplement of the scientific journal Clinical Oral Implants Research, published by Wiley (volume 37, number S31, e-posters section, pp. 44–325), available at https://doi.org/10.17605/OSF.IO/24EPH . The study was evaluated by renowned researchers in implant dentistry and osseointegration from the University of Gothenburg (Sweden), Katholieke Universiteit Leuven (Belgium), and the University of Zurich (Switzerland).
"The presentation and discussion of this study in a significant conference on oral implantology within senior researchers on implant dentistry and osseointegration was a very important experience in my professional and academic career" affirms Françoise Kleinsorgen (a PhD student co-supervised by Júlio C. M. Souza at the DEMaC and CICECO).
Despite the high success rate, dental implants can fail due to multifactorial issues related to both the implant and the patient. A major issue involves the progressive chronic inflammation at the peri-implant region, named peri-implantitis, that leads to a loss of the surrounding bone and a consequent loosening of the implant stability.
Currently, this topic is highly relevant in the medical field and prompted a clinical research study conducted by Françoise Kleinsorgen, a PhD student and dentist. The clinical study began in the subject of the CELLMET-G12-CESPU-2025 project (IUCS/CESPU) and some tasks have been carried out at the DEMaC and CICECO in collaboration with the iBiMED, University of Aveiro.
A PRISMA-oriented systematic review published by Françoise Kleinsorgen, Júlio C. M. Souza et al, followed was carried out on PubMed and Scopus regarding the detection of submicron-scale titanium debris at peri-implant tissues focusing on the analytical methods. Previous clinical studies reveal submicron-scale titanium debris at peri-implant tissues although the particles' detection depends on the microscopic method (Figura 1 e 2).
Figure 1. Schematics on the method for harvesting titanium debris and cells from the peri-implant tissues.
Some studies reported the presence of titanium debris associated with the oxidative stress and activation of pro-inflammatory cytokines to osteoclastogenesis (i.e., RANKL/RANK/OPG) and other inflammatory mediators such as IL-1β, IL-6, TNF-α, PGE2 (https://doi.org/10.1186/s11671-026-04741-0).
Figure 2. Presence of titanium debris released from dental implants and their interactions with the cells from the peri-implant tissues.
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Researchers
Françoise Kleinsorgen
PhD Student
Júlio C. M. Souza
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