Development of a multifunctional biomaterial patch for buccal delivery of peptide-analogue treatments

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Project Details

Start date
2024-03-01
End date
2026-12-31
%
Acronym
BUCCAL-PEP
Reference
101091765
Funding
European Comission
Programme
HORIZON-CL4-2022-RESILIENCE-01
Budget
3.371.779 €
Our budget
539.648 €

Team

Description

Oral delivery of peptide macromolecules represents significant challenges for pharmaceutical research, including low bioavailability, dosage control and undesirable food interactions. The intention of the EU-funded BUCCAL-PEP project is to develop a technological platform for oromucosal delivery suitable for a broad range of peptide-analogue therapies. To this end, the consortium will develop a multifunctional biomaterial patch to allow buccal (in the cheek) delivery of therapies using an integration of permeation enhancers with biomaterials and peptide analogues. The objective is to design, select and manufacture a lead product for the treatment of type 2 diabetes as a showcase indication and validate its performance in vivo in large animal models.

Main Local Researcher

João Mano

Coordination

UNIVERSITY COLLEGE DUBLIN - NATIONAL UNIVERSITY OF IRELAND

Partners

ADHEXPHARMA; CAMBRIDGE INNOVATION TECHNOLOGIES CONSULTING LIMITED; CATALYZE B.V.; CHARITÉ - UNIVERSITAETSMEDIZIN BERLIN (C-UMB); DANMARKS TEKNISKE UNIVERSITET; NOVO NORDISK A/S; UNIVERSIDADE DE AVEIRO

Groups

G5 - Biomimetic, Biological and Living Materials;

link

https://cordis.europa.eu/project/id/10109176

Sponsors

Sponsors
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