Sustainable 4D hydrogels functionalised with plant-based nanoparticles for bone regeneration in cancer patients

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Project Details

Start date
2025-06-01
End date
2029-05-31
%
Acronym
GreenNanoBone
Reference
101177877
Funding
European Comission
Programme
HORIZON-IA - HORIZON Innovation Actions
Budget
8.649.982 €
Our budget
397.781 €

Team

Description

Biocompatible 4D materials for bone regeneration in MRONJ patients Medication-related osteonecrosis of the jaw (MRONJ) is a rare but severe side effect of bone-targeting agents (BTAs) such as bisphosphonates, prescribed to breast cancer survivors to lower the risk of secondary bone cancer. MRONJ can cause progressive jawbone destruction, leading to infections, difficulty eating, and malnutrition. The EU-funded GreenNanoBone project will develop sustainable, biocompatible, and antimicrobial 4D materials that promote bone and tissue regeneration for the prevention and treatment of MRONJ. This injectable or printable material will be designed for non-invasive surgical use, with AI to optimise plant-derived substances and ensure compliance with medical standards. The project will uncover the mechanisms behind MRONJ, improve the quality of life, and offer new treatment options for complex fractures.

Main Local Researcher

João Mano

Coordination

UNIVERSITY OF LIVERPOOL

Partners

AARHUS UNIVERSITETSHOSPITAL; AARHUS UNIVERSITY; ASPHALION S.L.; EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (EURICE); F6S EU TECH INNOVATION NETWORK DESIGNATED ACTIVITY COMPANY; GDANSKI UNIWERSYTET MEDYCZNY; GUYS AND ST THOMAS’ NHS FOUNDATIONTRUST; JAGIELLONIAN UNIVERSITY; KOBENHAVNS UNIVERSITET; LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST); MYBIOTECH GMBH; STICHTING VUMC; TAMPEREEN KORKEAKOULUSÄÄTIÖ SR; UNIVERSIDADE DE AVEIRO; UNIVERSITETET I BERGEN; UNIVERSITY OF HELSINKI

Groups

G5 - Biomimetic, Biological and Living Materials;

link

https://cordis.europa.eu/project/id/101177877

Sponsors

Sponsors
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