Hybrid living bioengineered hierachical constructs with self-oxygenating capability for bone engineering

Descrição

Advances in tissue engineering aim to revolutionise tissue repair and regeneration through 3D scaffolds with encapsulated cells. However, the architecture and composition of these hybrid constructs are compromised by inadequate oxygen and nutrient flow. Funded by the HORIZON programme, the O2CELLS project aims to combine natural biomaterials, self-oxygenating microalgae, and tissue progenitor cells to build structured microtissues with robust vascular networks. Researchers will obtain unique proteins and stem cells from perinatal tissues and combine them with microcapsules containing microalgae and cells, generating biomaterials with angiogenic and osteogenic potential. The resultant constructs will be employed both for therapy and as disease models.

Coordenador

João Mano

Coordenação

Universidade de Aveiro (UA)

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