authors |
Bastos, AR; Vicente, CMS; Oliveira-Silva, R; Silva, NJO; Tacao, M; da Costa, JP; Lima, M; Andre, PS; Ferreira, RAS |
nationality |
International |
journal |
SENSORS |
author keywords |
photonic; integrated optics; sol-gel; biosensors; E. coli; organic-inorganic hybrid |
keywords |
ESCHERICHIA-COLI; REFRACTIVE-INDEX; LABEL-FREE; FIBER TECHNOLOGY; BACTERIAL-GROWTH; PERSPECTIVE; PERFORMANCE; CELL |
abstract |
The development of portable low-cost integrated optics-based biosensors for photonics-on-a-chip devices for real-time diagnosis are of great interest, offering significant advantages over current analytical methods. We report the fabrication and characterization of an optical sensor based on a Mach-Zehnder interferometer to monitor the growing concentration of bacteria in a liquid medium. The device pattern was imprinted on transparent self-patternable organic-inorganic di-ureasil hybrid films by direct UV-laser, reducing the complexity and cost production compared with lithographic techniques or three-dimensional (3D) patterning using femtosecond lasers. The sensor performance was evaluated using, as an illustrative example, E. coli cell growth in an aqueous medium. The measured sensitivity (2 x 10(-4) RIU) and limit of detection (LOD = 2 x 10(-4)) are among the best values known for low-refractive index contrast sensors. Furthermore, the di-ureasil hybrid used to produce this biosensor has additional advantages, such as mechanical flexibility, thermal stability, and low insertion losses due to fiber-device refractive index mismatch (similar to 1.49). Therefore, the proposed sensor constitutes a direct, compact, fast, and cost-effective solution for monitoring the concentration of lived-cells. |
publisher |
MDPI |
issn |
1424-8220 |
year published |
2018 |
volume |
18 |
issue |
3 |
digital object identifier (doi) |
10.3390/s18030840 |
web of science category |
Chemistry, Analytical; Electrochemistry; Instruments & Instrumentation |
subject category |
Chemistry; Electrochemistry; Instruments & Instrumentation |
unique article identifier |
WOS:000428805300161
|
ciceco authors
impact metrics
journal analysis (jcr 2019):
|
journal impact factor |
3.275 |
5 year journal impact factor |
3.427 |
category normalized journal impact factor percentile |
74.528 |
dimensions (citation analysis):
|
|
altmetrics (social interaction):
|
|
|