Synthesis of 4,5-disubstituted-1H-1,2,3-triazoles

authors	Rocha, DHA; Pinto, DCGA; Silva, AMS
nationality	International
journal	MONATSHEFTE FUR CHEMIE
author keywords	Alkyne; Cycloaddition; NMR spectroscopy; Heterocycles
keywords	AZIDE-ALKYNE CYCLOADDITION; ONE-POT SYNTHESIS; CLICK CHEMISTRY; BIOLOGICAL EVALUATION; ACID-CHLORIDES; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; SONOGASHIRA REACTION; PALLADIUM CATALYST; TERMINAL ALKYNES; LIQUID-CRYSTALS
abstract	Two-step procedure, a palladium catalyzed Sonogashira cross-coupling reaction of aroyl chlorides with aryl acetylenes, and 1,3-dipolar cycloaddition of the 1,3-diarylprop-2-yn-1-ones with sodium azide under catalyst free conditions achieved the synthesis of aryl(4-aryl-1H-1,2,3-triazol-5-yl)methanones in moderate-to-good chemical yields (30-90%). The procedures allowed the synthesis of 4,5-disubstituted-1H-1,2,3-triazol scaffolds containing electron-neutral, -withdrawing, or -donating groups. [GRAPHICS] .
publisher	SPRINGER WIEN
issn	0026-9247
isbn	1434-4475
year published	2019
volume	150
issue	8
beginning page	1479
ending page	1486
digital object identifier (doi)	10.1007/s00706-019-02463-x
web of science category	Chemistry, Multidisciplinary
subject category	Chemistry
unique article identifier	WOS:000477624300010