abstract
Over the past two decades, the CICECO-hub scientists have devoted substantial efforts to advancing bioactive inorganic materials based on calcium phosphates and alkali-free bioactive glasses. A key focus has been the deliberate incorporation of therapeutic ions like Mg, Sr, Zn, Mn, or Ga to enhance osteointegration and vascularization, confer antioxidant properties, and impart antimicrobial effects, marking significant contributions to the field of biomaterials and bone tissue engineering. Such an approach is expected to circumvent the uncertainties posed by methods relying on growth factors, such as bone morphogenetic proteins, parathyroid hormone, and platelet-rich plasma, along with their associated high costs and potential adverse side effects. This comprehensive overview of CICECO-hub ' s significant contributions to the forefront inorganic biomaterials across all research aspects and dimensionalities (powders, granules, thin films, bulk materials, and porous structures), follows a unified approach rooted in a cohesive conceptual framework, including synthesis, characterization, and testing protocols. Tangible outcomes [injectable cements, durable implant coatings, and bone graft substitutes (scaffolds) featuring customized porous architectures for implant fixation, osteointegration, accelerated bone regeneration in critical-sized bone defects] were achieved. The manuscript showcases specific biofunctional examples of successful biomedical applications and effective translations to the market of bone grafts for advanced therapies.
keywords
BETA-TRICALCIUM PHOSPHATE; ZIRCONIA-TOUGHENED ALUMINA; SPRAYED HYDROXYAPATITE COATINGS; BONE-GRAFT SUBSTITUTES; IN-VITRO BIOACTIVITY; CALCIUM-PHOSPHATE; MECHANICAL-PROPERTIES; THERMAL-STABILITY; ANTIBACTERIAL ACTIVITY; CRYSTAL-STRUCTURE
subject category
Engineering; Materials Science
authors
Fernandes, HR; Kannan, S; Alam, M; Stan, GE; Popa, AC; Buczynski, R; Golebiewski, P; Ferreira, JMF
our authors
Hugo Alexandre Gonçalves da Rocha Fernandes
Junior Researcher
José Maria da Fonte Ferreira
Retired ProfessorGroups
G3 - Electrochemical Materials, Interfaces and Coatings
G5 - Biomimetic, Biological and Living Materials
Projects
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
acknowledgements
This research is part of the project No. 2021/43/P/ST7/02418 co-funded by the National Science Centre and the European Union's Ho- rizon 2020 research and innovation programme under the Marie Sk & lstrok;o- dowska-Curie grant agreement No 945339 . JMFF, RB, PG gratefully acknowledge the financial support provided by the Polish National Science Centre for the POLONEZ BIS 1 "BAGBONE", Project no. 536651. JMFF would like to thank all the national and international research collaborators for their valuable contributions, especially for the papers covered in this review article. This work was developed within the scope of the project CICECO- Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC) . The support from the Department of Health Research - Indian Council of Medical Research [DHR-ICMR] , India [Reference: R.11013/28/2021-GIA/HR dated November 25, 2021] is recognized by SK and MA. GES and ACP are thankful to the Core Program of the National Institute of Materials Physics within the National Research Development and Innovation Plan 2022-2027, carried out with the support of the Romanian Ministry of Research, Innovation and Digitalization under the project PC2-PN23080101.