abstract
Bioactive glasses in the CaO-MgO-Na2O-P2O5-SiO2-CaF2 system are highly promising materials for bone and dental restorative applications. Furthermore, if thermally treated, they can crystallize into diopside-fluorapatite-wollastonite glass-ceramics (GCs), which exhibit appealing properties in terms of mechanical behaviour and overall bone-regenerative potential. In this review, we describe and critically discuss the genesis, development, properties and applications of bioactive glass "1d" and its relevant GC derivative products, which can be considered a good example of success cases in this class of SiO2/CaO-based biocompatible materials. Bioactive glass 1d can be produced by melt-quenching in the form of powder or monolithic pieces, and was also used to prepare injectable pastes and three-dimensional porous scaffolds. Over the past 15 years, it was investigated by the authors of this article in a number of in vitro, in vivo (with animals) and clinical studies, proving to be a great option for hard tissue engineering applications.
keywords
CAO-MGO-SIO2 SYSTEM; BONE REGENERATION; CERAMICS; WOLLASTONITE; BIOCOMPATIBILITY; CRYSTALLIZATION; DIFFERENTIATION; SCAFFOLDS; COATINGS; COLLAGEN
subject category
Chemistry
authors
Tulyaganov, DU; Agathopoulos, S; Dimitriadis, K; Fernandes, HR; Gabrieli, R; Baino, F
our authors
Hugo Alexandre Gonçalves da Rocha Fernandes
Junior Researcheracknowledgements
This study was partially carried out within the project "Artificial Intelligence-based design of 3D PRINTed scaffolds for the repair of critical-sized BONE defects-I-PRINT-MY-BONE" funded by the European Union-Next Generation EU within the PRIN 2022 program (D.D. 104-02/02/2022 Ministero dell'Universita e della Ricerca). This manuscript reflects only the authors' views and opinions, and the Ministry cannot be considered responsible for them.