abstract
The partition coefficients of seven low molecular weight compounds were tested in different aqueous two-phase systems. The ionic composition of each system included specific salt additives, and it was found that there is a linear relationship between the solute partition coefficients and the presence of different salt additives. The study suggests that the solute structure and the type of ions influence the solute response to the ionic environment. Additionally, it was observed that the solutes' polar surface area and the solvent-accessible surface area are the essential structural features governing partitioning in aqueous two-phase systems.
keywords
SOLVENT PROPERTIES; POLYETHYLENE-GLYCOL; ORGANIC-COMPOUNDS; OPTICAL-ROTATION; METHYLENE GROUP; FREE-ENERGY; PARTITION
subject category
Chemistry
authors
Costa, M; Madeira, PP; Uversky, VN; Zaslavsky, BY
our authors
Pedro António Palma Madeira
Junior ResearcherProjects
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
acknowledgements
This research was funded by FCT-Fundac & atilde;o para a Ciencia e a Tecnologia, developed within the scope of the CICECO-Aveiro Institute of Materials project, UIDB/50011/2020, UIDP/50011/2020, and LA/P/0006/2020. It is funded by national funds (O.E.) through FCT-Fundac & atilde;o para a Ciencia e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5, and 6 of article 23 of the Decree-Law 57/2016, of 29 August, changed by Law 57/2017, of 19 July.