abstract
Marine polysaccharides are widely available sustainable renewable macromolecules, which have attracted considerable attention owing to their enhanced biocompatibility, biodegradability, noncytotoxic, nonimmunogenic properties, and close similarity to the native cellular microenvironment of tissues and organs. Herein, a comprehensive overview of the main sources and properties of most studied cationic, anionic, and neutral marine-origin polysaccharides, their main chemical functionalization strategies, as well as their processing into advanced biofunctional materials/devices is provided. Several recent examples are given on the bottom-up processing of marine-origin polysaccharide-based biomaterials in the form of nano-/microparticles and capsules, nanofibers, thin films, membranes, hydrogels, cryogels, and (bio)inks to be used as high added-value antimicrobial coatings, adhesives, and wound dressings, or in food packaging, cosmetics, controlled drug delivery, in vitro disease modeling, or tissue engineering and regenerative medicine. The main challenges hampering the clinical translation and commercialization of most marine-origin polysaccharide-based biomaterials and devices, and future perspectives in the field are also discussed.
keywords
ALKYNE CLICK REACTION; INJECTABLE HYALURONIC-ACID; ONE-POT SYNTHESIS; CHONDROITIN SULFATE; FACILE SYNTHESIS; EXTRACELLULAR-MATRIX; CONTROLLED-RELEASE; KAPPA-CARRAGEENAN; CROSS-LINKING; FUNCTIONAL MODIFICATION
subject category
Biochemistry & Molecular Biology; Chemistry; Polymer Science
authors
Sousa, V; Monteiro, LPG; Rocha, DHA; Rodrigues, JMM; Borges, J; Mano, JF
our authors
Djenisa Rocha
Researcher
João Borges
Assistant Researcher
João M. M. Rodrigues
Assistant Researcher
João Mano
Full professor
Vera Catarina Ferreira de Sousa
PhD StudentProjects
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
acknowledgements
This work was supported by the European Union's Horizon Europe research and innovation programme under grant agreement no. 101079482 ("SUPRALIFE"). V.S., L.P.G.M., J.M.M.R., and J.B. gratefully acknowledge FCT for the individual PhD grants (10.54499/2020.06771.BD-V.S.; 10.54499/2020.06767.BD-L.P.G.M.) and individual Assistant Researcher contracts (10.54499/2023.07239.CEECIND/CP2840/CT0004-J.M.M.R.; 10.54499/2020.00758.CEE-CIND/CP1589/CT0007-J.B.) under the Scientific Employment Stimulus-Individual Call. This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC).