abstract
Over the last decade, 3D bioprinting has gained increasing popularity, being a technique capable of producing well-defined tissue-like structures. One of its most groundbreaking features is the ability to create personalized therapies tailored to the specific demands of individual patients. However, challenges including the selection of materials and crosslinking strategies, still need to be addressed to enhance ink characteristics and develop robust biomaterials. Herein, the authors showcase the potential of overcoming these challenges, focusing on the use of versatile, fast, and selective thiol-ene click chemistry to formulate inks for 3D bioprinting. The exploration of natural polymers, specifically proteins and polysaccharides, will be discussed and highlighted, outlining the advantages and disadvantages of this approach. Leveraging advanced thiol-ene click chemistry and natural polymers in the development of 3D printable bioinks may face the current challenges and is envisioned to pave the way towards innovative and personalized biomaterials for biomedical applications.
keywords
HYALURONIC-ACID HYDROGELS; GELATIN HYDROGELS; CROSS-LINKING; TISSUE; PHOTOPOLYMERIZATION; COLLAGEN; ALGINATE; BEHAVIOR; BIOINK
subject category
Materials Science
authors
Malafaia, AP; Sobreiro-Almeida, R; Rodrigues, JMM; Mano, JF
our authors
Andreia Malafaia
PhD Student
João M. M. Rodrigues
Assistant Researcher
João Mano
Full professor
Rita Sobreiro Almeida
Junior ResearcherProjects
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
acknowledgements
This work was developed within the scope of the project CICECO - Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020) , financed by national funds through the FCT/MEC (PIDDAC) , by the European Research Council Advanced Grant "REBORN" (grant agreement No. ERC-2019-ADG-883370) , and by the European Union's Horizon 2020 and Horizon Europe research and innovation programmes, under the grants agreements No. 953169 (InterLynk) and 101079482 (SUPRALIFE) , respectively. A.P.M. acknowledge the research scholarship (BI/UI89/11121/2023) in the frame of the project InterLynk. R.S.A. (doi:10.54499/2022.04605.CEE CIND/CP1720/CT0021) and J.M.M.R. (2023.07239.CEECIND) gratefully acknowledge FCT for their individual researcher contract under the Scientific Employment Stimulus - Individual Call.