Magnetic and thermo-responsive microparticles based on calcium phosphates with high potential to produce structures for bone regeneration and local hyperthermia

abstract

Magnetic calcium phosphate (CaP) nanoparticles have been explored for a wide range of applications, namely biodevices for bone regeneration and local cancer treating through hyperthermia therapy. Numerous shaping techniques to obtain dense and porous ceramic structures are based on colloidal processing principles, in which parameters such as crystallinity, morphology and particle size play an important role in obtaining high solids concentration suspensions to guarantee ceramic structures with high particle packing. With these considerations in mind, this work aims to obtain magnetic and thermo-responsive CaP microparticles, via wet chemical precipitation with the simultaneous addition of Fe2+ and Fe3+. Magnetic microparticles with the ability to preserve their magnetic and magneto-thermal properties have been successfully achieved, due to the presence of well- distributed iron oxide nanocrystallites surrounded by CaP phases. This accomplishment promises great potential for the development of biodevices based on colloidal processing, as some Additive Manufacturing technologies.

keywords

BETA-TRICALCIUM PHOSPHATE; THERMAL-STABILITY; IRON; HYDROXYAPATITE; NANOPARTICLES; COMPOSITE; PHASE; PRECIPITATION; SUBSTITUTIONS; GAMMA-FE2O3

subject category

Materials Science

authors

Carvalho, TSS; Belob, JH; Abrantes, JCC; Bañobre-López, M; Lopes, D; Kovalevsky, A; Kaushal, A; Araújo, JP; Olhero, SM; Torres, PMC

Groups

G3 - Electrochemical Materials, Interfaces and Coatings
G5 - Biomimetic, Biological and Living Materials

Projects

Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)

Desenvolvimento de biomateriais não sinterizáveis à base de fosfatos de cálcio com bi-funcionalidade: regeneração e tratamento de cancro ósseo (2BBone)

Desenvolvimento de microdispositivos flexiveis a base de microagulhas de biocimento composito para administracao transdermica de fármacos; (FlexMicroDerm)

CICECO - Aveiro Institute of Materials (UIDB/50011/2020)

CICECO - Aveiro Institute of Materials (UIDP/50011/2020)

Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)

acknowledgements

T. S. S. Carvalho wishes to thank Fundacao para a Ciencia e Tecnologia (FCT) for supporting their work with a PhD grant (https://d oi.org/10.54499/2021.06481.BD). This study was funded by European Union's Horizon 2020 research and innovation programme under the scope of InterLynk project with grant agreement no. 953169. This work is also funded by FEDER funds through the COMPETE 2020 Programme and National Funds through FCT- Portuguese Foundation for Science and Technology under the projects 2BBone and FlexMicroDerm with references POCI-01-0145-FEDER-029940 (PTDC/CTM-CER/29940/2017) and POCI-01-0145-FEDER-029274 (PTDC/BTM-MAT/29274/2017), respectively. The authors also acknowledge the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.5449 9/UIDP/50011/2020) & LA/P/0006/2020(DOI 10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC) and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. J. H. Belo would like to acknowledge projects PTDC/EMETED/3099/2020, UIDP/04968/2020-Programatico, UIDB/04968/2020, NECL-NORTE-010145-FEDER022096 and CERN/FISTEC/0003/2019; and FCT for his contract DL57/2016 reference SFRH-BPD- 87430/2012. Diogo Lopes acknowledges the PhD scholarship by FCT (grant https://doi.org/10.54499/2020.06454.BD) and P. M. C. Torres acknowledge FCT for 2023.07934.CEECIND. Part of this work was also carried out in part through the use of the INL User Facilities.