abstract
Garcinia mangostana is a tropical tree native to India, Sri Lanka, and Southeast Asia. In Traditional Medicinal Systems (TMS), decoctions and infusions prepared from mangosteen fruits have effectively treated skin lesions and various inflammatory conditions. Researchers have also reported its extensive biological activities, viz. antimicrobial, antioxidant, anticancer, antidiabetic, neuroprotective, and cardioprotective effects. This literature review comprehensively describes the biological potential of G. mangostana over the last twenty-five years. It includes a discussion of the bioactive compounds of G. mangostana and their extraction, purification, and characterization processes. Antimicrobial, anticancer, antitumorigenic, antidiabetic, anti-inflammatory, neuroprotective, and antiparasitic activities are discussed in detail. Furthermore, the paper addresses the main obstacles associated with using mangosteen extracts and suggests ways to overcome these challenges. The medicinal properties of G. mangostana are primarily attributed to a-mangostin and other bioactive xanthones. However, other bioactive compounds with potential therapeutic activities remain not fully characterized. Therefore, developing effective extraction methods for these bioactive compounds, along with their characterization, possible bioactivities (pharmacodynamics), and any synergistic effects, is essential. toxicity (ADMET), are necessary. It is also worth considering plant parts other than the pericarp.
keywords
RESISTANT STAPHYLOCOCCUS-AUREUS; SUPERFICIAL SKIN INFECTION; ALPHA-MANGOSTIN; ANTIBACTERIAL ACTIVITY; PERICARP EXTRACT; ANTIOXIDANT ACTIVITY; MEDICINAL PROPERTIES; XANTHONES; L.; SPHEROIDS
subject category
Parasitology; Tropical Medicine
authors
Anis, Y; Labana, R; Mendonça, D; Ayunee, S; Dimasin, RVD; Bodade, R; Sukati, S; Boonhok, R; Oliveira, SMR; Girol, AP; Pereira, MD; Chooi-Ling, L; Samudi, C; Nissapatorn,
our authors
Diana Mendonça
Collaborator
Maria de Lourdes Gomes Pereira
Associate Professor with Aggregation