Arcyriaflavin A monohydrate

abstract

The asymmetric unit of the title compound comprises the monohydrated form of the natural product arcyriaflavin A [systematic name: 12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione monohydrate], C20H11N3O2 center dot H2O. Individual molecular units are engaged in hydrogen-bonding interactions, forming two-dimensional zigzag supramolecular layers parallel to the ((1) over bar 02) plane. The close packing of the layers is mediated by strong co-operative pi-pi stacking interactions, in tandem with interlayer hydrogen bonds involving the solvent water molecule.

keywords

PROTEIN-KINASE; INHIBITORS; POTENT

subject category

Chemistry; Crystallography

authors

Fernandes, JA; Paz, FAA; Marques, J; Marques, MPM; Braga, SS

our authors

acknowledgements

The authors are grateful to the Fundacao para a Ciencia e a Tecnologia (FCT, Portugal) for general financial support, for a postdoctoral research grant (No. SFRH/BPD/63736/2009, to JAF), for a doctoral research grant (No. SFRH/BD/44791/2008, to JM) and for specific funding toward the purchase of the single-crystal diffractometer.

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