Tunable transmembrane chloride transport by bis-indolylureas

abstract

A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayers.

keywords

AMBER FORCE-FIELD; ORGANIC-SOLVENTS; ANION RECEPTORS; LIPID-BILAYERS; PHOSPHOLIPID-BILAYERS; BINDING-PROPERTIES; CYSTIC-FIBROSIS; GELATORS; CHANNEL; PRODIGIOSINS

subject category

Chemistry

authors

Haynes, CJE; Moore, SJ; Hiscock, JR; Marques, I; Costa, PJ; Felix, V; Gale, PA

our authors

acknowledgements

We thank the EPSRC for studentships (SJM and CJEH) and a PhD Plus award (JRH). In addition we thank the EPSRC for access for the crystallographic facilities at the University of Southampton.66 The computational studies were funded by the FEDER through the Operational Program Competitiveness Factors - COMPETE and National Funds through FCT - Fundacao para a Ciencia e a Tecnologia under project PTDC/QUI-QUI/101022/2008. P.J.C. thanks FCT for the postdoctoral grant SFRH/BPD/27082/2006.

Share this project:

Related Publications

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".