resumo
The study of the solubility of important biomolecules such as flavonoids is essential to support the design of several separation processes in the food and pharmaceutical industries. Following our previous studies, new solubility data of hesperetin in the mixed solvents water + acetone, water + ethanol, and water + methanol were measured, at 298.2 K, by the isothermal shake-flask method. The results obtained show three solid-liquid phase diagrams with distinct features. Additionally, the solid crystals obtained from the solubility studies were analyzed by powder X-ray diffraction, infrared spectroscopy, and thermogravimetric analysis indicating that, depending on the mixed solvents composition, two different crystal structures of hesperetin, already described in the literature, can be obtained, corresponding either to the anhydrous or the monohydrate forms.
palavras-chave
CRYSTALLIZING DRUG PHASE; PLUS WATER MIXTURES; ETHANOL; DELIVERY; (R,S)-HESPERETIN; TRANSFORMATION; TEMPERATURES; FLAVONOIDS; NARINGENIN; QUERCETIN
categoria
Thermodynamics; Chemistry; Engineering
autores
Ferreira, O; Schroder, B; Pinho, SP
nossos autores
Bernd Schroder
Bolseiro de pós-DoutoramentoGrupos
Projectos
agradecimentos
The authors acknowledge FCT-Fundacao para a Ciencia e a Tecnologia and the European Social Fund (ESF) under the 3rd Community Support Framework (CSF) for the projects Pest-C/CTM/LA0011/2011 and PTDC/AAC-AMB/121161/2010 and for the postdoctoral grant (SFRH/BPD/38637/2007) of Bernd Schroder. This work is also supported by project PEst-C/EQB/LA0020/2011, financed by FEDER through COM-PETE-Programa Operacional Factores de Competitividade and by FCT.