resumo
Spherical and monodispersed sub-micrometer sized particles of organic-inorganic hybrids were prepared by means of a sol-gel non-emulsion method using the biopolymer kappa-carrageenan and the alkoxysilane 3-isocyanatopropyltriethoxysilane (ICPTES). The structural characterization of the carrageenan-silica hybrid particles was performed by using FTIR spectroscopy and solid-state Si-29 and C-13 NMR spectroscopy and confirmed that.-carrageenan was covalently linked to the siliceous network via urethane bonds. Zeta-potential measurements indicate the hybrids were functionalized on the surface with sulfonate groups from the polysaccharide. These hybrids display thermal sensitivity, which is of great relevance for biomedical applications such as drug encapsulation and thermally controlled drug-delivery systems.
palavras-chave
KAPPA-CARRAGEENAN; WATERBORNE POLYURETHANE; COLLOIDAL SILICA; SPECTROSCOPY; IONS; SIZE; DEGRADATION; PARTICLES; GROWTH; EU3+
categoria
Chemistry
autores
Soares, SF; Trindade, T; Daniel-da-Silva, AL
nossos autores
Ana Luísa Daniel da Silva
Investigador Principal
Sofia Soares
Investigador Júnior
Tito Trindade
Professor CatedráticoProjectos
agradecimentos
This work was financed by national funding from Fundacao para a Ciencia e a Tecnologia (FCT) through the project PTDC/CTM-NAN/120668/2010, by FEDER through program COMPETE, and by national funding through FCT in the frame of project CICECO - FCOMP-01-0124-FEDER- 037271 (ref. FCT Pest-C/CTM/LA0011/2013) and project FCT UID/CTM/50011/2013. The authors thank the National Electronic Microscopy Network (RNME) for microscopy facilities and acknowledge the Professor Joaquim Faria research group [Faculty of Engineering of the University of Porto (FEUP)] for the nitrogen sorption data. A.L.D.-d.-S. acknowledges FCT for the FCT Investigator Programme.