resumo
The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
palavras-chave
NF-KAPPA-B; CONTROLLED-RELEASE STRATEGIES; POSTMENOPAUSAL OSTEOPOROSIS; OSTEOBLAST DIFFERENTIATION; RHEUMATOID-ARTHRITIS; OVARIECTOMIZED RATS; SIGNALING PATHWAY; NATURAL-PRODUCTS; STEM-CELLS; MECHANISMS
categoria
Pharmacology & Pharmacy
autores
Lavrador, P; Gaspar, VM; Mano, JF
nossos autores
Projectos
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
agradecimentos
The authors would like to acknowledge the support of the European Research Council grant agreement ERC-2014-ADG-669858 for project ATLAS. The authors also acknowledge the financial support by the Portuguese Foundation for Science and Technology (FCT) through a post-doctoral grant (SFRH/BPD/119983/2016, Vitor Gaspar). The authors also acknowledge the project CICECO - Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013), financed by national funds through the FCT/MEC and, when appropriate, co-financed by FEDER under the PT2020 partnership agreement. The authors also acknowledge Smart Servier Medical Art (https://smart.servier.com/), for providing image vectors for Fig. 1, licensed under the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/license/by/3.0/).