resumo
Recognition of neoplastic metabolic reprogramming as one of cancer's hallmarks has paved the way for developing novel metabolism-targeted therapeutic approaches. The use of plant-derived natural bioactive compounds for this endeavor is especially promising, due to their diverse structures and multiple targets. Hence, over the past decade, a growing number of studies have assessed the impact of phytochemicals on tumor cell metabolism, aiming at improving current knowledge on their mechanisms of action and, at the same time, evaluating their potential as anti-cancer metabolic modulators. In this Review, we focus on three classes of plant-derived compounds with promising anti-cancer activity-phenolic compounds, isoprenoids, and alkaloids-to describe their effects on major energetic and biosynthetic pathways of human tumor cells. Such a comprehensive and integrated account of the ability of these compounds to hit different metabolic targets is expected to contribute to the rational design and critical assessment of novel anti-cancer therapies based on natural-product mediated metabolic reprogramming.
palavras-chave
FATTY-ACID SYNTHASE; PYRUVATE-DEHYDROGENASE COMPLEX; PENTOSE-PHOSPHATE PATHWAY; ACTIVATED PROTEIN-KINASE; CELL LUNG-CANCER; WARBURG-LIKE METABOLISM; GLUCOSE-METABOLISM; EPIGALLOCATECHIN GALLATE; UP-REGULATION; GROWTH-INHIBITION
categoria
Agriculture; Chemistry; Food Science & Technology
autores
Guerra, AR; Duarte, MF; Duarte, IF
nossos autores
Ângela Guerra
Estudante de doutoramento
Iola Melissa Fernandes Duarte
Investigador Principal
Maria de Fátima Pereira Duarte
Investigador PrincipalProjectos
CICECO - Aveiro Institute of Materials (UID/CTM/50011/2013)
Eucalyptus triterpenic biological activity (PTDC/AGR-FOR/3187/2012)
agradecimentos
This work was developed in the scope of the projects CICECO - Aveiro Institute of Materials (ref. FCT UID/CTM/50011/2013) and UID/AGR/00115/2013 to ICAAM - Institute of Mediterranean Agricultural and Environmental Sciences, financed by national funds through the FCT/MEC and when applicable co-financed by the European Regional Development Fund (FEDER) under the PT2020 Partnership Agreement. Funding to the project NEucBark-New valorization strategies for Eucalyptus spp. Bark Extracts (PTDC/AGR-FOR/3187/2012) by FEDER through COMPETE and by national funds through FCT, financial support from the European Union Framework Programme for Research and Innovation HORIZON 2020, under the TEAMING Grant agreement No. 739572 - The Discoveries CTR, and the FCT-awarded grants SFRH/BD/98635/2013 are also acknowledged. I.F.D. further acknowledges the FCT/MCTES for research contracts under the Program "Investigador FCT".