Genotoxicity of gold nanoparticles in the gilthead seabream (Sparus aurata) after single exposure and combined with the pharmaceutical gemfibrozil
authors Barreto, A; Luis, LG; Pinto, E; Almeida, A; Paiga, P; Santos, LHMLM; Delerue-Matos, C; Trindade, T; Soares, AMVM; Hylland, K; Loureiro, S; Oliveira, M
nationality International
journal CHEMOSPHERE
author keywords Metal nanoparticles; Lipid regulator; Erythrocytes; Mixtures; Comet assay; Nuclear abnormalities
keywords DNA-DAMAGE; NUCLEAR ABNORMALITIES; GENE-EXPRESSION; COMET ASSAY; OXIDATIVE STRESS; ERYTHROCYTES; MARINE; WATER; SIZE; CYTOTOXICITY
abstract Due to their diverse applications, gold nanoparticles (AuNPs) are expected to increase of in the environment, although few studies are available on their mode of action in aquatic organisms. The genotoxicity of AuNPs, alone or combined with the human pharmaceutical gemfibrozil (GEM), an environmental contaminant frequently detected in aquatic systems, including in marine ecosystems, was examined using gilthead seabream erythrocytes as a model system. Fish were exposed for 96 h to 4, 80 and 1600 mu g L-1 of 40 nm AuNPs with two coatings - citrate or polyvinylpyrrolidone; GEM (150 mu g L-1); and a combination of AuNPs and GEM (80 mu g L-1 AuNPs + 150 mu g L-1 GEM). AuNPs induced DNA damage and increased nuclear abnormalities levels, with coating showing an important role in the toxicity of AuNPs to fish. The combined exposures of AuNPs and GEM produced an antagonistic response, with observed toxic effects in the mixtures being lower than the predicted. The results raise concern about the safety of AuNPs and demonstrate interactions between them and other contaminants. (C) 2018 Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0045-6535
isbn 1879-1298
year published 2019
volume 220
beginning page 11
ending page 19
digital object identifier (doi) 10.1016/j.chemosphere.2018.12.090
web of science category Environmental Sciences
subject category Environmental Sciences & Ecology
unique article identifier WOS:000458591200002
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journal analysis (jcr 2019):
journal impact factor 5.778
5 year journal impact factor 5.705
category normalized journal impact factor percentile 89.245
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