Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy


Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications. Here, the development of flexible and multifunctional chitosan-based bionanocomposites with a mixed reduced graphene oxide-iron oxide (rGO-Fe3-xO4) filler is described. The filler is prepared by one-pot synthesis, ensuring good dispersibility of the Fe3-xO4 nanoparticles and rGO within the chitosan matrix during solvent casting. The resulting bionanocomposites present superparamagnetic response at room temperature. The antioxidant activity is 9 times higher than that of pristine chitosan. The mechanical properties of the films can be tuned from elastic (similar to 8 MPa) chitosan films to stiff (similar to 285 MPa) bionanocomposite films with 50% filler. The magnetic hyperthermia tests showed a temperature increase of 40 degrees C in 45 s for the 50% rGO-Fe3-xO4 film. Furthermore, the composites have no cytotoxicity to the nontumorigenic (HaCat) cell line, which confirms their biocompatibility and highlights the potential of these materials for biomedical applications, such as hyperthermia treatments.




Materials Science


Barra, A; Alves, Z; Ferreira, NM; Martins, MA; Oliveira, H; Ferreira, LP; Cruz, MM; Carvalho, MD; Neumayer, SM; Rodriguez, BJ; Nunes, C; Ferreira, P

nossos autores


This work was developed within the scope of the projects: CICECO-Aveiro Institute of Materials, (FCT Ref. UIDB/50011/2020 and UIDP/50011/2020); CESAM (FCT Ref. UID/AMB/50017/2019); BioISI (FCT Ref. UID/MULTI/04046/2019); CQB (FCT Ref. UID/MULTI/00612/2013); and I3N (FCT Ref. UID/CTM/50025/2019) financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. The project M-ERA-NET2/0021/2016 BIOFOODPACK -Biocomposite Packaging for Active Preservation of Food is acknowledged for funding. ZA, NMF, HO and PF thank FCT for the grants (PD/BD/117457/2016, SFRH/BPD/111460/2015, CEECIND/04050/2017 and IF/00300/2015, respectively). CN is funded by national funds (OE), through FCT - Fundacao para a Ciencia e a Tecnologia, I. P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the DecreeLaw 57/2016, of August 29, changed by Law 57/2017, of July 19. SMN and BJR acknowledge the support of Science Foundation Ireland (16/IA/4584, 14/US/I3113 and 07/IN1/B931). This research was partially supported by COST action 15107, Grant No. 101016-080937.

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