Fabrication of three dimensional bioactive Sr2+ substituted apatite scaffolds by gel-casting technique for hard tissue regeneration
authors Ramadas, M; Ferreira, JMF; Ballamurugan, AM
nationality International
journal JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
author keywords apatite; biocompatibility; biodegradable; porosity; scaffold
abstract This study aimed to fabricate three-dimensional (3D) bioactive Sr2+-substituted apatite (Sr-HAP) scaffolds prepared by gel-casting with polymer sponge infiltration technique. 3D Sr-HAP scaffolds were prepared as engineering constructs with interconnected porous structure with a pore size of 200-600 mu m ranging from a 10 x 10 x 6 mm size was designed. The characterization of X-ray diffraction, field emission scanning electron microscopy, and energy dispersion spectroscopy was utilized in order to evaluate the crystalline phase, structure, and morphology in the interconnected porous of the synthesized Sr-HAP scaffold. The bioactive and biocompatible of the resultant Sr-HAP scaffolds were analyzed by using simulated body fluid solution. Furthermore, the cytotoxicity and proliferation of MG-63 cell lines on the scaffolds were examined in 24 h culture. Furthermore, in vivo experiments demonstrated that the tibia bone defect with 4 mm diameter in rabbits was successfully healed by Sr-HAP porous scaffold after 45 days implantation. The histological images indicated the improved cell proliferation and new bone formation occurred in the porous scaffold treated group. The results indicated that the fabricated Sr-HAP scaffold is a promising capacity to infuse bone regeneration and promote in vivo tissue repair.
publisher WILEY
issn 1932-6254
isbn 1932-7005
year published 2021
volume 15
issue 6
beginning page 577
ending page 585
digital object identifier (doi) 10.1002/term.3197
web of science category 9
subject category Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell Biology; Engineering, Biomedical
unique article identifier WOS:000640684000001
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journal impact factor 3.078
5 year journal impact factor 3.174
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