Protease Inhibitors as Promising Weapons against COVID-19: Focus on Repurposing of Drugs used to Treat HIV and HCV Infections
authors da Costa, LJ; Pereira, MM; Ramos, LD; Silva, LN; de Mello, TP; Branquinha, MH; dos Santos, ALS
nationality International
journal CURRENT TOPICS IN MEDICINAL CHEMISTRY
keywords MOLECULAR-DYNAMICS; SARS-COV-2; BINDING
abstract As a part of the efforts to quickly develop pharmaceutical treatments for COVID-19 through repurposing existing drugs, some researchers around the world have combined the recently released crystal structure of SARS-CoV-2 M-pro in complex with a covalently bonded inhibitor with virtual screening procedures employing molecular docking approaches. In this context, protease inhibitors (PIs) clinically available and currently used to treat infectious diseases, particularly viral ones, are relevant sources of promising drug candidates to inhibit the SARS-CoV-2 M-pro, a key viral enzyme involved in crucial events during its life cycle. In the present perspective, we summarized the published studies showing the promising use of HIV and HCV PIs as potential repurposing drugs against the SARS-CoV-2 M-pro.
publisher BENTHAM SCIENCE PUBL LTD
issn 1568-0266
isbn 1873-5294
year published 2021
volume 21
issue 16
beginning page 1429
ending page 1438
digital object identifier (doi) 10.2174/1568026621666210701093407
web of science category 10
subject category Chemistry, Medicinal
unique article identifier WOS:000703889700001
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 3.218
5 year journal impact factor 3.335
category normalized journal impact factor percentile 64.754
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