Influence of the Operating Conditions on the Release of Corrosion Inhibitors from Spray-Dried Carboxymethylcellulose Microspheres


Sodium carboxymethylcellulose (CMC-Na) microparticles, containing corrosion inhibitor benzotriazole (BTA), were prepared using different spray drying processing parameters, with the purpose of future application in protective coatings for the delivery of corrosion inhibitors. The effects of the processing parameters, such as inlet temperature and spray flow rate, are discussed herein. The biopolymeric CMC-Na microparticles obtained were characterized morphologically by SEM and TEM, and their release profile studied by UV-Vis. The results show that the prepared microparticles (microspheres) were homogeneous, spherically shaped and of a matrix-type nature. Additionally, it was observed that the inlet temperature and spray flow rate significantly influenced the release profiles and process yields. From the different process parameters tested, it was found that the best conditions to achieve higher process yields, higher encapsulation efficiencies and better release properties, were an inlet temperature of 170 degrees C, a pump rate of 2.5 mL/min, and a drying air-flow rate of 440 L/h.




Chemistry; Engineering; Materials Science; Physics


Calegari, F; Sousa, I; Ferreira, MGS; Berton, MAC; Marino, CEB; Tedim, J

nossos autores


This work was developed in the scope of the project PVE-CAPES (n ffi 88881.064969/2014-01), and financed by the national agency CAPES. The authors gratefully acknowledge the support of UFPR, SENAI-PR and UA for the infrastructure, CNPq for the productivity fellowship (C.E.B. Marino-303126/2019-1), CAPES for financial support, and the Electron Microscopy Center of UFPR (CME-UFPR). This work was also supported by Portugal 2020 through the European Regional Development Fund (ERDF) in the frame of the Operational Competitiveness and Internationalization Programme (POCI), in the scope of the project MAGICOAT POCI-01-0145-FEDER-016597/PTDC/CTMBIO/2170/2014 and in the scope of the project CICECO-Aveiro Institute of Materials, POCI-01-0145FEDER-007679 (FCT Ref. UID/CTM/50011/2013). The project was co-financed by national funds through the FCT/MEC.

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