resumo
The regulation of cellular behavior within a three-dimensional (3D) environment to execute a specific function remains a challenge in the field of tissue engineering. In native tissues, cells and matrices are arranged into 3D modular units, comprising biochemical and biophysical signals that orchestrate specific cellular activities. Modular tissue engineering aims to emulate this natural complexity through the utilization of functional building blocks with unique stimulation features. By adopting a modular approach and using well-designed biomaterials, cellular microenvironments can be effectively decoupled from their macro-scale surroundings, enabling the development of engineered tissues with enhanced multifunctionality and heterogeneity. We overview recent advancements in decoupling the cellular micro-scale niches from their macroenvironment and evaluate the implications of this strategy on cellular and tissue functionality. In this review, we overview recent advancements in decoupling the cellular microenvironment from the surrounding macroenvironment in the development of biomimetic engineered tissues.
palavras-chave
STEM-CELLS; SCAFFOLDS; BIOMATERIALS; GENERATION; HYDROGELS; CAPSULES
categoria
Chemistry; Materials Science; Physics; Polymer Science
autores
Ghasemzadeh-Hasankolaei, M; Pinheiro, D; Nadine, S; Mano, JF
nossos autores
João Mano
Professor Catedrático
Maryam Ghasemzadeh Hasankolaei
Estudante de doutoramento
Sara Nadine
Investigador JúniorProjectos
PRInted Symbiotic Materials as a dynamic platform for Living Tissues production (PRISM-LT)
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
This work was financed by the European Research Council Advanced Grant ''REBORN'' (grant agreement n. ERC-2019-ADG-883370). We acknowledge the support of national funds (OE) through FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the project "TETRISSUE" (PTDC/BTM-MAT/3201/2020). Diogo Pinheiro was funded under Horizon Europe project PRISM-LT (GA: 101070913). Maryam Ghasemzadeh-Hasankolaei acknowledges FCT for the PhD Grant (SFRH/BD/147418/2019). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC).