resumo
Autogenous bone grafts have long been considered the optimal choice for bone reconstruction due to their excellent biocompatibility and osteogenic properties. However, their limited availability and associated donor site morbidity have led to exploration of alternative bone substitutes. Cryogels, with their interconnected porosity, shape recovery, and enhanced mass transport capabilities, have emerged as a promising polymer-based solution. By incorporating bioactive glasses and nanofillers, cryogel composites offer bioactivity, cost-efficiency, and easy cell integration. This approach not only enhances bone regeneration but also underscores the broader role of nanotechnology in regenerative medicine. This mini-review discusses the advancement of organic-inorganic composites, focusing on biopolymeric cryogels and inorganic elements for reinforcement. We highlight how cryogels can be integrated into minimally invasive procedures, reducing patient distress and complications, and advanced 3D-printing techniques that enable further customization of these materials to mimic bone tissue architecture, offering potential for patient-specific treatments.
palavras-chave
SCAFFOLDS; HYDROXYAPATITE; INTEGRATION; HYDROGEL; GROWTH
categoria
Chemistry; Science & Technology - Other Topics; Materials Science; Physics
autores
Castanheira, EJ; Rodrigues, JMM; Mano, JF
nossos autores
André Filipe Castanheira Horta
Estudante de doutoramento
João M. M. Rodrigues
Investigador Auxiliar
João Mano
Professor CatedráticoGrupos
G2 - Materiais Fotónicos, Eletrónicos e Magnéticos
G5 - Materiais Biomiméticos, Biológicos e Vivos
Projectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
agradecimentos
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020), and LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020), financed by national funds through the FCT/MCTES (PIDDAC). This work was also funded by the European Union's Horizon research and innovation programme under the project InterLynk (Grant Agreement No. 953169). The authors would like to acknowledge the financial support from the Portuguese Foundation for Science and Technology (FCT) for the individual Ph.D. grant (SFRH/BD/144880/2019 - E.J.C.) and individual assistant researcher contract (2023.07239.CEECIND - J.M.M.R), respectively. Figure , Figure , and the Table of Contents graphic were produced with the assistance of Servier Medical Art (https://smart.servier.com).