resumo
Background: Breast cancer is a heterogeneous malignant disease with a varying prognosis and is classified into four molecular subtypes. It remains one of the most prevalent cancers globally, with the tumor microenvironment playing a critical role in disease progression and patient outcomes. Methods: This study evaluated tumor samples from 40 female patients with luminal A and B breast cancer, utilizing flow cytometry to phenotypically characterize the immune cells and tumor cells present within the tumor tissue. Results: The luminal B-like tumor samples exhibited increased infiltration of CD4+ cells, regulatory T cells (Tregs), and Th17 cells and decreased levels of NK cells, gamma delta T cells, Th1 cells, and follicular T cells, which is indicative of a more immunosuppressive tumor microenvironment. Conclusions: These findings suggest that luminal B-like tumors have a microenvironment that is less supportive of effective anti-tumor immune responses compared to luminal A tumors. This study enhances the understanding of the immunological differences between luminal subtypes of breast cancer and identifies potential new therapeutic targets and biomarkers that could drive advancements in precision medicine for breast cancer management.
palavras-chave
MEMORY T-CELLS; INFILTRATING LYMPHOCYTES; FOLLICULAR HELPER; SUBTYPES; RECURRENCE; SURVIVAL; SIZE
categoria
Biochemistry & Molecular Biology
autores
Moura, T; Caramelo, O; Silva, I; Silva, S; Gonçalo, M; Portilha, MA; Moreira, JN; Gil, AM; Laranjeira, P; Paiva, A
nossos autores
Ana Maria Pissarra Coelho Gil
Professor Associado com AgregaçãoProjectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
AMG acknowledges the project CICECO-Aveiro Institute of Materials and FCT/MCTES (PIDDAC), UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020), UIDP/50011/2020(DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020).