resumo
Despite relevant advances, the pharmaceutical industry continues to strive with the limited adaptability, moisture management, and discomfort caused by existing wound dressings. Adding to these challenges are the bioavailability and pharmacokinetics of common (bio)therapeutics, overall leading to unmet clinical demands, safety concerns, and poor patient compliance. Ionogels, a versatile class of materials comprising ionic liquids (ILs) confined in an organic or inorganic solid network, have been proposed to overcome these drawbacks. They have demonstrated the ability to enhance the antimicrobial and mechanical properties of the resulting materials while allowing remarkable improvements in drug solubility and their delivery to targeted sites. Nowadays, safety investigations and clinical trials are still required to fully leverage the potential of ionogels for human applications. However, the recent FDA approval of the New Drug Application MRX-5LBT (R), a transdermal drug delivery system, opens promising perspectives toward the clinical translation of ionogels. This review focuses on recent advances achieved in the design of ionogels for pharmaceutical applications, viz. in topical formulations to promote wound healing with antimicrobial activity, and as platforms to improve drug pharmacokinetics (solubility and bioavailability), and their delivery at targeted specific sites with controlled release behaviour.
palavras-chave
IONIC LIQUIDS; SUPRAMOLECULAR GELATORS; MEMBRANES; TOXICITY; HYDROGEL; ELECTROLYTES; SOLUBILITY; EXTRACTION; STABILITY; GELS
categoria
Science & Technology - Other Topics; Materials Science
autores
Pedro, AQ; Castro, LS; Coutinho, JAP; Freire, MG
nossos autores
Augusto Pedro
Investigador Júnior
Mara Guadalupe Freire Martins
Professor CatedráticoGrupos
G4 - Materiais Renováveis e Economia Circular
G5 - Materiais Biomiméticos, Biológicos e Vivos
Projectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
agradecimentos
This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020) , UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020) , fi nanced by National funds through the FCT/MCTES (PIDDAC) . This work was additionally developed within the scope of the projects mVACCIL (EXPL/BII-BTI/0731/2021, DOI 10.54499/EXPL/BII-BTI/0731/2021) and PureDNA (2022.03394.PTDC, DOI 10.54499/2022.03394.PTDC) , fi nancially supported by National funds (OE) , through FCT/MCTES. Augusto Q. Pedro and Leonor S. Castro acknowledge FCT, respectively, for the research contract CEEC-IND/02599/2020 (DOI 10.54499/2020.02599.CEECIND/CP1589/CT0023) under the Scientific Stimulus - Individual Call, and for the PhD grant 2020/05090/BD (DOI: 10.54499/2020.05090.BD) .