resumo
Electroactive biomaterials and, in particular, piezoelectric ones are gaining insight into tissue engineering and biomedical applications. Collagen is one of the most available biomaterials found in nature, and the present study focus on the evaluation of its piezoelectric response. Collagen extracted from bovine skin was used and the piezoelectric response was correlated to the physicochemical, thermal, morphological and mechanical properties. A dense fibrillar microstructure was observed and the mechanical properties, which depend on the specific amino acids composition, showed tensile strength and maximum strain values of 34 MPa and 18 %, respectively. Collagen films exhibited approximately 25 % weight loss after 1 day in PBS solution, increasing to about 30 % and 100 % at day 2 and 4, respectively. A piezoelectric response of 0.44 pm/V was obtained, demonstrating the collagen film suitability for electroactive materials in biomedical applications.
palavras-chave
PHYSICOCHEMICAL PROPERTIES; CROSS-LINKING; DENATURATION; FIELDS; SIGNAL
categoria
Biochemistry & Molecular Biology; Chemistry; Polymer Science
autores
Andonegi, M; Diez, AG; Costa, CM; Romanyuk, KN; Kholkin, AL; de la Caba, K; Guerrero, P; Lanceros-Mendez, S
nossos autores
Andrei Kholkin
Investigador Jubilado
Konstantin Nikolaevich Romanyuk
Investigador Júnioragradecimentos
The authors thank the Fundacao para a Ciencia e Tecnologia (FCT) for financial Support under the framework of Strategic Funding UIDB/04650/2020, UID/FIS/04650/2020, UID/04650 Physics Centre of Minho and Porto Universities (CF-UM-UP), UID/EEA/04436/2020, and under projects POCI-01-0247-FEDER-046985, and 2022.03781.PTDC funded by national funds through FCT and by the ERDF through the COMPETE2020-Programa Operacional Competitividade e Internacionalizacao (POCI). The authors also thank the FCT for financial support under FCT investigator 2020.04028.CEECIND (DOI: 10 .54499/2020.04028.CEECIND/CP1600/CT0018) (C.M.C.). This work was also supported by MCI/AEI10.13039/501100011033 and by "ERDF A way of making Europe" (PID2021-124294OB-C22) and the Basque Government (IT1658-22 and POS_2022_1_0007). This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. It is also funded by national funds (OE), through FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. This study forms part of the Advanced Materials program and was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) and by the Basque Government under the IKUR program and Elkartek programs. This work has been supported by PID2022-138572OB-C42 project funded by MCIN/AEI/10.13039/5011 00011033/FEDER, UE, and the project BIOIMP_ACE_MAS_6_E, co funded by the European Union through the Interreg VI-A Spain Portugal Program (POCTEP) 2021-2027. A.G.D. wants to thank the Basque Government for funding under an FPI grant (PRE_2022_2_0046) .