resumo
Herein, a novel approach to the controlled formation of chitosan-Ag nanocomposites (NCs) with different structures and tunable chemical/biological properties was proposed. The chitosan-Ag NCs were obtained using hydrothermal synthesis and varying the concentrations of components. The hypothesis of chitosan-Ag NC synthesis using polysaccharide coils as a "microreactor" system was confirmed. A comparative analysis of the physicochemical characteristics of the NCs with single-core-shell and multi-core-shell structures was carried out, and the "structure-property" relationship was revealed. The obtained NCs exhibited excellent antiradical properties, comparable to the activity of phenolic acids: the IC50 values were 0.051, 0.022, and 0.019 mg/mL for CS7, CS5, and caffeic acid, respectively. A mechanism for the antiradical activity of chitosan-Ag NCs was discussed. The redox activity of the NCs was found to be 11.4 and 2.3 mg ABTS per 1 mg of Ag in CS5 and CS7, respectively. The proposed environmentally friendly one-pot, one-step synthesis of silver nanoparticles inside chitosan "microreactors" represents an innovative approach to designing hybrid materials with nanoscale control of desired structure and properties. These findings pave the way for further optimization of biopolymer-silver nanostructures for various biomedical and industrial applications, including the design of a new type of hybrid catalysts such as nanozymes.
palavras-chave
SILVER NANOPARTICLES; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; OXIDATIVE DISSOLUTION; AGGREGATION KINETICS; OPTICAL-PROPERTIES; FACILE SYNTHESIS; GREEN; OPTIMIZATION; REDUCTION
categoria
Biochemistry & Molecular Biology; Chemistry; Polymer Science
autores
Hileuskaya, K; Kraskouski, A; Ihnatsyeu-Kachan, A; Saichuk, A; Pinchuk, S; Nikalaichuk, V; Ladutska, A; Kulikouskaya, V; Neves, MC; Freire, MG; Kim, S
nossos autores
Mara Guadalupe Freire Martins
Professor Catedrático
Márcia Carvalho Neves
Investigador JúniorProjectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
agradecimentos
This study received financial support from the Korea Institute of Science and Technology (No. 2E33132) and from the Belarusian Republican Foundation for Fundamental Research (grant No. B23UZB-084) . Additionally, this study was supported by the Belarusian State Program of Scientific Research "Convergence 2025" (project 3.03.1) . This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 (DOI 10.54499/UIDB/50011/2020) , UIDP/50011/2020 (DOI 10.54499/UIDP/50011/2020) & LA/P/0006/2020 (DOI 10.54499/LA/P/0006/2020) , financed by national funds through the FCT/MCTES (PIDDAC) . Marcia C. Neves acknowledges FCT - Fundacao para a Ciencia e a Tecnologia, I.P. for the researcher contract (DOI 10.54499/CEECIND/00383/2017/CP14 59/CT0031).