Rheological, microstructural, and in vitro characterization of hybrid chitosan-polylactic acid/hydroxyapatite composites

resumo

In this work, hybrid chitosan/hydroxyapatite composites material were developed and characterized. The polymer matrix was first dissolved in polylactic acid, and then hydroxyapatite (HA) was added as filler material. The effects of the added amounts of a crosslinking agent (genipin) and of the concentrations of lactic acid, and of the presence of HA powder on the evolution of rheological properties were evaluated. A significant decrease of gelation time with increasing amounts of crosslinking agent was observed, the effect being even more pronounced in the presence of HA. The chitosan matrix and the composites with a chitosan/HA weight ratio of 2/5 were characterized using microstructural analysis and in vitro tests. The formation of large pore sizes in the chitosan-based scaffolds was favored by low concentrations of lactic acid and genipin. The in vitro tests in synthetic body fluid revealed an extensive formation of an apatitic layer onto the surface of the chitosan/HA composite scaffolds crosslinked with genipin. (c) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 916-922, 2009

palavras-chave

SYNTHETIC BODY-FLUIDS; HYDROXYAPATITE POWDERS; 37-DEGREES-C; SCAFFOLDS; TISSUE

categoria

Engineering; Materials Science

autores

Araujo, ABA; Lemos, AF; Ferreira, JMF

nossos autores

agradecimentos

Contract grant sponsor: Portuguese Foundation for Science and Technology contract grant numbers: POCTI/ CTM/60207/2004; SFRH/BD/8755/2002 Contract grant sponsor: CICECO

Partilhe este projeto

Publicações similares

Usamos cookies para atividades de marketing e para lhe oferecer uma melhor experiência de navegação. Ao clicar em “Aceitar Cookies” você concorda com nossa política de cookies. Leia sobre como usamos cookies clicando em "Política de Privacidade e Cookies".