NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments


After the serendipitous discovery of cisplatin, a platinum-based drug with chemotherapeutic\\r\\neffects, an incredible amount of research in the area of coordination chemistry has been produced.\\r\\nOther transition metal compounds were studied, and several new relevant metallodrugs have been\\r\\nsynthetized in the past few years. This review is focused on coordination compounds with first-row\\r\\ntransition metals, namely, copper, cobalt, nickel or manganese, or with zinc, which have potential or\\r\\neffective pharmacological properties. It is known that metal complexes, once bound to organic drugs,\\r\\ncan enhance the drugs’ biological activities, such as anticancer, antimicrobial or anti-inflammatory\\r\\nones. NSAIDs are a class of compounds with anti-inflammatory properties used to treat pain or fever.\\r\\nNSAIDs’ properties can be strongly improved when included in complexes using their compositional\\r\\nN and O donor atoms, which facilitate their coordination to metal ions. This review focuses on the\\r\\nresearch on this topic and on the promising or effective results that complexes of first-row transition\\r\\nmetals and NSAIDs can exhibit.


Ariana C. F. Santos, Luís P. G. Monteiro, Adriana C. C. Gomes, Fátima Martel, Teresa M. Santos and Bárbara J. M. Leite Ferreira

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