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tipo de financiamento |
European Comission |
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programa |
ERC-2014-ADG |
acrónimo/
referência |
ATLAS |
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referência alternative |
669858 |
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grupo(s) de investigação |
5 - materiais biomédicos e biomiméticos;
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departamento |
Chemistry (DQ) |
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período de execução |
2016-04-01 - 2020-11-30 (
56 Meses )
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data de extensão projeto |
2021-04-30 (
5 Meses extra )
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resumo/
palavras-chave |
New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine and direct signals, structural and chemical arrangement of the extra-cellular matrix, mechanical signals…) should be then incorporated into the design of truly biomimetic biomaterials. ATLAS proposes rather unique toolboxes combining smart biomaterials and cells for the ground-breaking advances of engineering fully time-self-regulated complex 2D and 3D devices, able to adjust the cascade of processes leading to faster high-quality new tissue formation with minimum pre-processing of cells. Versatile biomaterials based on marine-origin macromolecules will be used, namely in the supramolecular assembly of instructive multilayers as nanostratified building-blocks for engineer such structures. The backbone of these biopolymers will be equipped with a variety of (bio)chemical elements permitting: post-processing chemistry and micro-patterning, specific/non-specific cell attachment, and cell-controlled degradation. Aiming at being applied in bone TE, ATLAS will integrate cells from different units of tissue physiology, namely bone and hematopoietic basic elements and consider the interactions between the immune and skeletal systems. These ingredients will permit to architect innovative films with high-level dialogue control with cells, but in particular sophisticated quasi-closed 3D capsules able to compartmentalise such components in a “globe-like” organization, providing local and long-range order for in vitro microtissue development and function. Such hybrid devices could be used in more generalised front-edge applications, including as disease models for drug discovery or test new therapies in vitro. |
coordenador
/ip local |
João Mano |
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ciceco status |
Coordenador |
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instituíção proponente |
Universidade de Aveiro (UA) |
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instituições participante(s) |
no
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participação industrial |
Não |
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parceiro(s) internacional |
Não |
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orçamento total |
2.498.988€
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orçamento ciceco |
2.438.987€
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centro de custos |
3.89.215 |
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link |
http://cordis.europa.eu/project/rcn/199773_en.html
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One-Step All-Aqueous Interfacial Assembly of Robust Membranes for Long-Term Encapsulation and Culture of Adherent Stem/Stromal CellsVilabril, S; Nadine, S; Neves, CMSS; Correia, CR; Freire, MG; Coutinho, JAP; Oliveira, MB; Mano, JF
2021, ADVANCED HEALTHCARE MATERIALS, 10, 10,
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Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cell-laden constructsAmaral, AJR; Gaspar, VM; Lavrador, P; Mano, JF
2021, BIOFABRICATION, 13, 3,
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An Immunomodulatory Miniaturized 3D Screening Platform Using Liquefied CapsulesNadine, S; Correia, CR; Mano, JF
2021, ADVANCED HEALTHCARE MATERIALS, 10, 10,
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Natural Origin Biomaterials for 4D Bioprinting Tissue-Like ConstructsCosta, PDC; Costa, DCS; Correia, TR; Gaspar, VM; Mano, JF
2021, ADVANCED MATERIALS TECHNOLOGIES, 6, 10,
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Design of Protein-Based Liquefied Cell-Laden Capsules with Bioinspired Adhesion for Tissue EngineeringGomes, MC; Costa, DCS; Oliveira, CS; Mano, JF
2021, ADVANCED HEALTHCARE MATERIALS, 10, 19,
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Minimalist Tissue Engineering Approaches Using Low Material-Based Bioengineered SystemsCorreia, CR; Bjorge, IM; Nadine, S; Mano, JF
2021, ADVANCED HEALTHCARE MATERIALS, 10, 9,
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Bioinstructive Layer-by-Layer-Coated Customizable 3D Printed Perfusable Microchannels Embedded in Photocrosslinkable Hydrogels for Vascular Tissue EngineeringSousa, CFV; Saraiva, CA; Correia, TR; Pesqueira, T; Patricio, SG; Rial-Hermida, MI; Borges, J; Mano, JF
2021, BIOMOLECULES, 11, 6,
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GelMA/bioactive silica nanocomposite bioinks for stem cell osteogenic differentiationTavares, MT; Gaspar, VM; Monteiro, MV; Farinha, JPS; Baleizao, C; Mano, JF
2021, BIOFABRICATION, 13, 3,
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Strategies for re-vascularization and promotion of angiogenesis in trauma and diseaseGoncalves, RC; Banfi, A; Oliveira, MB; Mano, JF
2021, BIOMATERIALS, 269,
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New insights into the biomimetic design and biomedical applications of bioengineered bone microenvironmentsOliveira, CS; Leeuwenburgh, S; Mano, JF
2021, APL BIOENGINEERING, 5, 4,
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Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cellsBharmoria, P; Bisht, M; Gomes, MC; Martins, M; Neves, MC; Mano, JF; Bdikin, I; Coutinho, JAP; Ventura, SPM
2021, SCIENTIFIC REPORTS, 11, 1,
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Partial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid MaterialsMaciel, MM; Correia, TR; Gaspar, VM; Rodrigues, JMM; Choi, IS; Mano, JF
2021, ADVANCED FUNCTIONAL MATERIALS, 31, 29,
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Fabrication of Quasi-2D Shape-Tailored Microparticles using Wettability Contrast-Based PlatformsNeto, MD; Stoppa, A; Neto, MA; Oliveira, FJ; Gomes, MC; Boccaccini, AR; Levkin, PA; Oliveira, MB; Mano, JF
2021, ADVANCED MATERIALS, 33, 14,
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Capacitive interdigitated system of high osteoinductive/conductive performance for personalized acting-sensing implantsde Sousa, BM; Correia, CR; Ferreira, JAF; Mano, JF; Furlani, EP; dos Santos, MPS; Vieira, SI
2021, NPJ REGENERATIVE MEDICINE, 6, 1,
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Advanced Bottom-Up Engineering of Living ArchitecturesGaspar, VM; Lavrador, P; Borges, J; Oliveira, MB; Mano, JF
2020, ADVANCED MATERIALS, 32, 6,
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Biomedical applications of laminarinZargarzadeh, M; Amaral, AJR; Custodio, CA; Mano, JF
2020, CARBOHYDRATE POLYMERS, 232,
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Cell Encapsulation Systems Toward Modular Tissue Regeneration: From Immunoisolation to Multifunctional DevicesCorreia, CR; Nadine, S; Mano, JF
2020, ADVANCED FUNCTIONAL MATERIALS, 30, 26,
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Enzymatically degradable, starch-based layer-by-layer films: application to cytocompatible single-cell nanoencapsulationMoon, HC; Han, S; Borges, J; Pesqueira, T; Choi, H; Han, SY; Cho, H; Park, JH; Mano, JF; Choi, IS
2020, SOFT MATTER, 16, 26, 6063-6071.
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Fabrication of Artificial Nanobasement Membranes for Cell Compartmentalization in 3D TissuesZeng, JF; Sasaki, N; Correia, CR; Mano, JF; Matsusaki, M
2020, SMALL, 16, 24,
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Human Platelet Lysates-Based Hydrogels: A Novel Personalized 3D Platform for Spheroid Invasion AssessmentMonteiro, CF; Santos, SC; Custodio, CA; Mano, JF
2020, ADVANCED SCIENCE, 7, 7,
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