Spray-dried hydroxyapatite-5-Fluorouracil granules as a chemotherapeutic delivery system

authors	Santos, C; Rovath, CF; Franke, RP; Almeida, MM; Costa, MEV
nationality	International
journal	CERAMICS INTERNATIONAL
author keywords	Spray drying; Drug delivery; Hydroxyapatite; 5-Fluorouracil
keywords	HYDROXYAPATITE PARTICLES; RELEASE; NANOPARTICLES
abstract	This study describes the preparation and characterization of hydroxyapatite-5-Fluorouracil (5FU) granules, which are intended to be used as chemotherapeutic delivery matrices and bone regeneration templates. Suspensions of hydroxyapatite (Hap) nanoparticles in 5FU solution are spray dried as micro sized granules having donut type shape. Several spray drying temperatures are studied 80 degrees C being the optimized condition for obtaining granules composed by Hap and 5FU without secondary phases. The produced granules at 80 degrees C reveal a fast releasing rate of 5FU when soaked in buffer phosphate solution maintained at physiological temperature (37 degrees C, thereby indicating the potential application of the produced Hap matrices for drug delivery systems (DDSs). (C) 2008 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
publisher	ELSEVIER SCI LTD
issn	0272-8842
year published	2009
volume	35
issue	1
beginning page	509
ending page	513
digital object identifier (doi)	10.1016/j.ceramint.2008.01.012
web of science category	Materials Science, Ceramics
subject category	Materials Science
unique article identifier	WOS:000261818300086