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Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute
| authors | Abranches, DO; Benfica, J; Soares, BP; Leal-Duaso, A; Sintra, TE; Pires, E; Pinho, SP; Shimizu, S; Coutinho, JAP |
| nationality | International |
| journal | CHEMICAL COMMUNICATIONS |
| keywords | AQUEOUS-SOLUTIONS; SOLUBILIZATION; NICOTINAMIDE; DRUG; RIBOFLAVIN; STACKING; UREA |
| abstract | A recent proposal attributes the origin of hydrotropy to the water-mediated aggregation of hydrotrope molecules around the solute. Experimental evidence for this phenomenon is reported for the first time in this work, using(1)H-NMR. A new computational technique to quantify apolarity is introduced and is used to show that apolarity of both solute and hydrotrope is the driving force of hydrotropy. |
| publisher | ROYAL SOC CHEMISTRY |
| issn | 1359-7345 |
| isbn | 1364-548X |
| year published | 2020 |
| volume | 56 |
| issue | 52 |
| beginning page | 7143 |
| ending page | 7146 |
| digital object identifier (doi) | 10.1039/d0cc03217d |
| web of science category | Chemistry, Multidisciplinary |
| subject category | Chemistry |
| unique article identifier | WOS:000544483800014 |
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impact metrics
| journal analysis (jcr 2019): |
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| journal impact factor | 5.996 |
| 5 year journal impact factor | 5.818 |
| category normalized journal impact factor percentile | 81.073 |
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