Gold nanoparticles-based assays for biodetection in urine

authors	Antonio, M; Vitorino, R; Daniel-da-Silva, AL
nationality	International
journal	TALANTA
author keywords	Gold nanoparticles; Surface modification; Urine samples; Biodetection; Protein
keywords	DYNAMIC LIGHT-SCATTERING; OPTICAL-PROPERTIES; MASS-SPECTROMETRY; COLORIMETRIC DETECTION; COLLOIDAL GOLD; ULTRASENSITIVE DETECTION; METAL NANOPARTICLES; BLADDER-CANCER; SIZE; BIOMARKERS
abstract	Urine is a biofluid easy to collect through a non-invasive technique that allows collecting a large volume of sample. The use of urine for disease diagnosis is not yet well explored. However, it has gained attention over the last three years. It has been applied in the diagnosis of several illnesses such as kidney disease, bladder cancer, prostate cancer and cardiovascular diseases. In the last decade, gold nanoparticles (Au NPs) have attracted attention in biosensors' development for the diagnosis of diseases due to their electrical and optical properties, ability to conjugate with biomolecules, high sensitivity, and selectivity. Therefore, this article aims to present a comprehensive view of state of the art on the advances made in the quantification of analytes in urinary samples using AuNPs based assays, with a focus on protein analysis. The type of diagnosis methods, the Au NPs synthesis approaches and the strategies for surface modification aiming at selectivity towards the different targets are highlighted.
publisher	ELSEVIER
issn	0039-9140
isbn	1873-3573
year published	2021
volume	230
digital object identifier (doi)	10.1016/j.talanta.2021.122345
web of science category	17
subject category	Chemistry, Analytical
unique article identifier	WOS:000657143300009