Antibacterial activity of optically transparent nanocomposite films based on chitosan or its derivatives and silver nanoparticles
authors Pinto, RJB; Fernandes, SCM; Freire, CSR; Sadocco, P; Causio, J; Neto, CP; Trindade, T
nationality International
journal CARBOHYDRATE RESEARCH
author keywords Nanocomposites; Chitosan; Silver nanoparticles; Flexible thin films; Antibacterial activity
keywords ANTIMICROBIAL ACTIVITY; QUATERNARY AMMONIUM; CELLULOSIC FIBERS; GOLD; CHEMISTRY; SURFACE; CITRATE; AGENT; RAMAN; SIZE
abstract Colloidal silver nanoparticles (NPs) were prepared using the citrate and borohydride reduction methods and were then investigated as fillers in three matrices: unmodified chitosan, water-soluble chitosan and a N-alkyl chitosan derivative. The nanocomposites were used to prepare cast thin films (9-19 mu m thickness) and characterized for their optical and antimicrobial properties. The optical properties of the materials were adjusted either by varying the Ag NPs content in the films (0.5-3.9% w/w) or by using samples of Ag NPs with distinct particle size distributions. The antibacterial activity towards both Gram-positive (Staphylococcus aureus) and Gram-negative bacteria (Klebsiella pneumoniae and Escherichia coli) was investigated for the various composites. For the unmodified chitosan nanocomposites, the bactericidal effect depended on their Ag content while such an effect was always observed for water-soluble chitosan and N-alkyl chitosan based materials. This research provides a basis for the evaluation of chitosan/silver composites in applications requiring flexible films with tuned optical properties and antimicrobial activity. (C) 2011 Elsevier Ltd. All rights reserved.
publisher ELSEVIER SCI LTD
issn 0008-6215
year published 2012
volume 348
beginning page 77
ending page 83
digital object identifier (doi) 10.1016/j.carres.2011.11.009
web of science category Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic
subject category Biochemistry & Molecular Biology; Chemistry
unique article identifier WOS:000300926300010
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journal analysis (jcr 2019):
journal impact factor 1.841
5 year journal impact factor 1.973
category normalized journal impact factor percentile 37.125
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