João Mano

Vice Director

Short CV

João F. Mano, PhD in Chemistry (1996, Technical Univ. Lisbon), D.Sc. in Tissue Engineering Regenerative Medicine and Stem Cells (2012, Univ. Minho), is a full professor at the Department of Chemistry of the University of Aveiro (Portugal). During his career he has been teaching courses related to biomaterials science and technology, tissue engineering and physical chemistry of polymers and materials, in both undergraduate and graduate levels. He is the director of both Master and Doctoral Degrees in Biotechnology at the Univ. of Aveiro. He has also an appointment as Invited Professor (classe exceptionelle, since 2014) at University of Lorraine (France), and Visiting Professor in KAIST (South Korea) - 2019.

He belongs to the associate laboratory CICECO – Aveiro Institute of Materials where he is directing the COMPASS Research Group, founded in April 2016. His current research interests include the use of biomaterials and cells towards the development of transdisciplinary concepts especially aimed at being used in regenerative and personalised medicine. In particular, biomimetic and nano/micro-technology approaches have been applied to natural-derived biomaterials and surfaces in order to obtain biomedical devices with improved structural and (multi-)functional properties, or in the engineering of microenvironments to control cell behaviour and organization, to be used in therapies or in drug screening.

João F. Mano is author of 620+ original research or review papers in international journals (23800+ citations, h=78 – Web of Science), about 40 book chapters, and 6 patents as senior inventor. João F. Mano co-edited 9 special issues in international journals and 3 books. João F. Mano has been invited to review manuscripts from 275+ different international journals and to routinely evaluate projects from numerous private and state funding agencies from 18 different countries. João F. Mano supervised or co-supervised 57 MSc, 21 PhD students, and 40+ post-doctoral fellows.

He is the Editor-in-Chief of Materials Today Bio (Elsevier). He has been also part of a series of scientific societies and editorial boards of international journals, including Tissue Engineering (parts A, B and C), Advanced Healthcare Materials, Advanced Engineering Materials, Materials Today, Materials Letters, Materials Today Chemistry, Materials Today Advances, Journal of Tissue Engineering and Journal of Bioactive and Compatible Polymers. He has been coordinating or involved in many national and European research projects and participated in the organization of scientific events in the area of polymer/materials science and biomaterials/tissue engineering.

Professor João F. Mano has been member of scientific committees, organizing committees, referee and chairman in different international meetings. He was invited to present more than 100 invited/keynote/plenary talks in international conferences including EUROMAT, ESTAC, TERMIS (EU and AP chapters and World conferences), BIOMED, FBPS, NANOMED, COLAOB, ESB, SFB, World Biomaterials Conference, E-MRS, ESAO, EPF, ACS, CBECIMAT, NICE, Inter. HYMA, APME, APCChE, PPM, EPNOE, SELECTBIO.

João F. Mano has received different honours and awards: (i) fellow of the IUPAC (International Union of Pure and Applied Chemistry) since 2004; (ii) the Stimulus to Excellence Award by the Portuguese Minister for Science and Technology in 2005; (iii) the Materials Science and Technology Prize, attributed by the Federation of European Materials Societies (FEMS) in 2007 (iv) UNESCO Chair on Biomaterials attributed in 2008 from the University of Havana (Cuba); (v) the major BES innovation award in 2010 (at that time, one of the most recognised innovation prize in Portugal); (vi) recipient an Advanced Grant from the European Research Council (ERC-AdG), in 2015; (vii) received the title of Professor@Lorraine from the University of Lorraine, France, in 2018; (viii) recipient a Proof of Concept Grant from the European Research Council (ERC-PoC), in 2018; (ix) awarded with a Gutenberg Chair, supported  by the Great East Region of France, in 2019.


◊ Habilitation in Tissue Engineering, Regenerative Medicine and Stem Cells (Univ. of Minho) - 2012

◊ PhD in Chemistry (Technical University of Lisbon) - 1996

◊ Chemical Engineering degree (I.S.T.) - 1992.

Research Area

Bio-inspired materials: We take nature as a source of endless inspiration for the development of novel classes of polymer-based materials and processes, combining chemistry, materials science, and engineering tools.
Cell and Tissue Engineering: Tissue engineering addresses the scarcity of tissues/organs available for repair and transplantation, by adopting multidisciplinary strategies permitting the ex-vivo creation of implantable hybrid constructs through the integration of biomaterials, therapeutic cells and physicochemical signals.
Nano/micro platforms for biomedicine: Our group focuses on the use of an interplay and cutting-edge nano- and micro-technologies for addressing a multitude of biomedical applications, including those in diagnostics and therapy.

Representative Publications (last 5 years)

A.I. Neto, C.R. Correia, C.A. Custódio, J.F. Mano - Biomimetic miniaturized platform able to sustain arrays of liquid droplets for high-throughput combinatorial tests. Advanced Functional Materials, 24, 5096 (2014).

J. Borges, J.F. Mano - Molecular interactions driving the layer-by-layer assembly of multilayers. Chemical Reviews, 114, 8883 (2014)

C.A. Custódio, M.T. Cerqueira, A.P. Marques, R.L. Reis, J.F. Mano - Cell selective chitosan microparticles as injectable cell carriers for tissue regeneration. Biomaterials, 43, 23 (2015)

A.M.S. Costa, J.F. Mano - Highly robust hydrogels via a fast, simple and cytocompatible dual crosslinking-based process. Chemical Communications, 51, 15673 (2015)

C.R. Correia, R.P. Pirraco, M.T. Cerqueira, A.P. Marques, R.L. Reis, J.F. Mano - Semipermeable capsules wrapping a multifunctional and self-regulated co-culture microenvironment for osteogenic differentiation. Scientific Reports, 6, 21883 (2016)

S. Azevedo, A.M.S. Costa, A. Andersen, I.S. Choi, H. Birkedal, J.F. Mano - Bioinspired ultratough hydrogel with fast recovery, self-healing, injectability and cytocompatibility. Advanced Materials, 29, 1700759 (2017)

M.B. Oliveira, H.X.S. Bastos, J.F. Mano - Sequentially Moldable and Bondable Four-Dimensional Hydrogels Compatible with Cell Encapsulation. Biomacromolecules, 19(7), 2742-2749 (2018)

L.P. Ferreira, V.M. Gaspar, J.F. Mano - Bioinstructive microparticles for self-assembly of mesenchymal stem Cell-3D tumor spheroids. Biomaterials. 185, 240-275 (2018)

L.F. Santos, A.S. Silva, C.R. Correia, J.F. Mano - Physical immobilization of particles inspired by pollination. Proceedings of the National Academy of Sciences (USA), 116(12), 5405-5410 (2019)

I. Bjorge, I. Choi, C.R. Correia, J.F. Mano - Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation.Nanoscale, 11(35), 16214-16221 (2019)


[see complete list of publications in]

Ongoing Supervisions


Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)

PartnerFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers Regeneration

Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)

PartnerFundação para a Ciência e a Tecnologia

Bioinspired tile-matching to create ultrastructured bone microtissues in a close-to-native fashion (TETRISSUE)

PartnerFundação para a Ciência e a Tecnologia
endochondral ossification modular tissue engineering mechanobiology 3D co-cultures

Development of 4D wireless thermometry to target tumor ablation (PTDC/NAN-MAT/3901/2020)

PartnerFundação para a Ciência e a Tecnologia
Thermography Magnetic Nanoparticles Induced Hyperthermia Bioprinting

Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering. (REBORN)

CoordinatorEuropean Comission
Engineered bone tissue has many advantages over natural bone grafts, including safety and limitless supply. However, current engineering methods cannot generate large vascularised grafts capable of in vivo integration and remodelling. To address this problem, the EU-funded REBORN project proposes to combine biomaterials based on protein...

Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)

CoordinatorEuropean Comission
InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expected to be ...

A bioactivated nano-layered hydrogel for dermal regeneration in hard-to-heal ulcers (BioNaNor)

Local CoordinatorOther International
Several strategies have been developed to restore dermal function. These include collagen membranes, decellularized dermis from donors or synthetic graft alternatives. So far, these approaches have been unreliable at best and auto-grafts and transplants (that both create their own problems with donor site morbidity, risk for disease transfer and...

Bioengineered autonomous cell-biomaterials devices for generating humanised micro- tissues for regenerative medicine (ATLAS)

CoordinatorEuropean Comission
New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine an...

Biorrefinaria de microalgas Coccolithophore: uma abordagem para biomateriais sustentaveis (Coccolitho4BioMat)

PartnerFundação para a Ciência e a Tecnologia

BlueGlue: Bioinspired medical adhesives from marine macroalgae derived biopolymers (BLUEGLUE)

CoordinatorOther National
BLUEGLUE project aims to value and promote the sustainable and controlled production of macroalgae, a way that they can be certified and used into the development of products with high added value (biomedical products). The project is aligned with the structures of the circular and biological economy and aims to provide a boost to the emerging i...

Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)

PartnerFundação para a Ciência e a Tecnologia

Colonizacao 3D de celulas em hidrogeis de origem marinha atraves de padronizacao por microcanais para regeneracao ossea (PROMENADE)

PartnerFundação para a Ciência e a Tecnologia

Desenvolvimento de hidrogeis de inspiracao marinha multifuncionais e de elevado desempenho para regeneracao de cartilagem, reticulados com ligacoes nao-covalentes e bio-instrutivas deslizantes. (MARGEL)

CoordinatorFundação para a Ciência e a Tecnologia

Desenvolvimento de uma membrana periodontal multicamada composta por blocos inovativos a base de polimeros de origem marinha e enzima para regeneracao guiada de osso que possui mineralizacao enzimatica controlada. (MIMETIc)

PartnerFundação para a Ciência e a Tecnologia

Dispositivos Supramoleculares Auto-Regulados baseados na Complementaridade dos Pares de Base do ADN: Uma Tecnologia Biomimética e com Reconheciemnto Molecular para Isolar Células Específicas para Aplicações Biomédicas (SUPRASORT)

PartnerFundação para a Ciência e a Tecnologia

Enabling precision chemical methodologies applied to natural -based systems for the development of multifunctional biomedical devices (CHEM2NATURE)

Local CoordinatorEuropean Comission
CHEM2NATURE addresses current limitations of UMINHO in the Chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UMINHO seeks to improve the multifunctionality of natural-origin polymers, often with limited bioactivity and stimuli-responsiveness, and increase the performance of cell-based therapies. ...

European Network of Bioadhesion Expertise: Fundamental Knowledge to Inspire Advanced Bonding Technologies (COST Action CA15216)

Local CoordinatorEuropean Comission
Many organisms, ranging from bacteria and fungi to those much larger animals and plants use chemical and mechanical means to attach permanently or temporarily to surfaces. Some bioadhesives have advantages over synthetic counterparts in terms of their ability to function over a wide temperature range, in wet or dry environments, and to form stab...

Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models (AMNIOGEL)

CoordinatorEuropean Comission

Hidrogéis de Lisados de Plaquetas para Regeneração do Miocárdio (BEAT)

PartnerFundação para a Ciência e a Tecnologia

Hydralazine: Testing an off-label effect in Castration-Resistant Prostate Cancer (HyTherCaP)

Local CoordinatorFundação para a Ciência e a Tecnologia
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related deaths among men. In Portugal, it is the most incident cancer and the 3rd cause of death (1, 2). Although most of PCa are clinically indolent, a variable proportion of patients develop castration-resistant PCa (CRPC),...

Marine Origin Biopolymers as Innovative Building Blocks from the Sea for the Development of Bioresorbable Multilayered Membranes for guided bone regeneration (BLUETEETH)

CoordinatorFundação para a Ciência e a Tecnologia
Natural origin polymers from algae and arthropods can be obtained in large scale, and a great effort has been paid to find applications for such high-added value materials. Periodontal disease is frequent in humans and constitutes, together with dental caries, the principal cause of tooth loss in adults. Currently, one of the available treatment...

Metodologias eficientes para a conjugação de polissacarídeos naturais com péptidos para obtenção de membranas multifuncionais para regeneração periodontal. (COP2P)

PartnerFundação para a Ciência e a Tecnologia

Novel 3D platforms to engineer bone microtissues for in vitro disease models (Microbone)

CoordinatorEuropean Comission
Osteosarcoma is a rare but devastating bone tumour that mainly affects children, adolescents and elderly. This type of tumour is very resistant to therapy, being thus urgent to find new effective treatments. In vitro tumour models can recapitulate many aspects of the natural tumour environment, and could be used to improve the predictive value o...

Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)

PartnerFundação para a Ciência e a Tecnologia

Regeneração Óssea Orquestrada pela Interação de Células do Sistema Imunitário com Microlaboratórios de Células e Microplataformas Padronizadas (CIRCUS)

PartnerFundação para a Ciência e a Tecnologia

Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus:a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche (ELASTISLET)

Local CoordinatorEuropean Comission
ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them ...


Brewer's yeast polysaccharides - A review of their exquisite structural features and biomedical applications

Bastos, R; Oliveira, PG; Gaspar, VM; Mano, JF; Coimbra, MA; Coelho, E

Cell Response in Free-Packed Granular Systems

Cunha, AF; Matias, AFV; Dias, CS; Oliveira, MB; Araujo, NAM; Mano, JF
2022, ACS APPLIED MATERIALS & INTERFACES, 14, 36, 40469-40480.


Cunha, AF; Oliveira, MB; Mano, JF

Core-shell microcapsules: biofabrication and potential applications in tissue engineering and regenerative medicine

Ladeira, BM; Custodio, CA; Mano, JF
2022, BIOMATERIALS SCIENCE, 10, 9, 2122-2153.


Ferreira, L; Gaspar, V; Mendes, L; Duarte, I; Mano, J

Designing highly customizable human based platforms for cell culture using proteins from the amniotic membrane

Deus, IA; Santos, SC; A, C; Mano, JF


Monteiro, M; Gaspar, V; Mano, J

Emerging modulators for osteogenic differentiation: a combination of chemical and topographical cues for bone microenvironment engineering

Jesus, D; Pinho, AR; Gomes, MC; Oliveira, CS; Mano, JF
2022, SOFT MATTER, 18, 16, 3107-3119.

Endo- and Exometabolome Crosstalk in Mesenchymal Stem Cells Undergoing Osteogenic Differentiation

Bispo, DSC; Michalkova, L; Correia, M; Jesus, CSH; Duarte, IF; Goodfellow, BJ; Oliveira, MB; Mano, JF; Gil, AM
2022, CELLS, 11, 8.

Engineering immunomodulatory hydrogels and cell-laden systems towards bone regeneration

Nadine, S; Correia, CR; Mano, JF

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