Ana Maria Pissarra Coelho Gil

Present position: Associate Professor "com agregação", Department of Chemistry , University of Aveiro since January 2007
Previous positions:
1998-2007 Associate Professor, Department of Chemistry , University of Aveiro
1993-98 Lecturer, Department of Chemistry , University of Aveiro;
1990-93 Assistente, Department of Chemistry , University of Aveiro;
1988-1990 Assistente Estagiaria, Department of Chemistry , University of Aveiro;
1987-1988:Assistente Estagiaria, School of Biotechnology, Portuguese Catholic University, Oporto.

Academic degrees:
1992: Doctorate in Chemistry, University of East Anglia, U.K., with a thesis titled "Spectroscopic Studies of Proteins in the Solid State";
1990: Provas de Aptidao Pedagogica e Capacidade Cientifica on "Gelification of polysaccharides: study of the effect of ions" and "Study of sulphated polysaccharides by FTIR";
1987: Licenciatura in Chemistry, Faculty of Sciences and Technology, University of Coimbra, Portugal, completed in October 1987 with mark 17/20.

Summary track record: Ana Gil has published 121 SCI papers, 3 books co-edited, 24 book chapters,29 proceedings and other papers, and presented more than 200 conference communications (130 posters + 79 orals), including 48 invited lectures. Metrics WoK (www.isiknowledge.com): h-index=35, 3,192 citations without self-citations). AGil has supervised 8 Postdocs (+ 1 ongoing), 11 PhD theses (+ 6 ongoing), 17 Master theses (+ 3 ongoing), and 11 other researchers (+ 1 ongoing). AGil’s teaching activities have been extensive in all cycles of university training (1^stdegree, Master, Doctoral) in Chemistry, Biochemistry and Biotechnology. She has setup, coordinated and participated in several undergraduate (1^stcycle) courses (including the teaching of > 1300 1^styear students and supervision of ca. 40 undergraduate theses), Master courses (Metabolomics, Food Quality and Safety; including supervision of 14 theses) and Doctoral courses (Metabolomics, NMR Spectroscopy).

AGil´s scientific interests have been increasingly developed with CICECO-Aveiro Institute of Materials, since the genesis of this Associate Laboratory (2002). More recently, her interests in the biological testing of materials has justified her intention to carry out scientific activities also in the context of newly created The Discoveries Centre for Regenerative and Precision Medicine, University of Aveiro, Campus de Santiago, 3810-193 Aveiro, Portugal.

Present interests

• Metabolomics (based mainly on NMR) of human biofluids, tissues and cellular systems for the biochemical characterisation of diseases: biomarker search for early diagnosis, prognosis and monitoring of diseases and therapeutics, while considering the effects of lifestyle and nutritional habits. Biological validation of metabolomic hypotheses through correlation studies of different omic data. 

Main diseases investigated: prenatal/newborn diseases and cancer (mainly lung, renal, osteosarcoma, pancreatic). Other diseases: children’s early carie, asthma, age-related macular degeneration. 

• Metabolomics testing of bio- and/or nano-materials for assessment of in vitroandin vivo biological performance: tissue regeneration, drug delivery, biocompatibility and biotoxicity. 
• Characterisation of stem cell differentiation through metabolomics to monitor and guide lineage development and regeneration of engineered tissues.
• Metabolomic assessment of environmental effects (or exposomes) on human metabolism: heavy metals, other pollutants, nanoparticles.
• Metabolomics for the routine quality control of products and processes in the food industry: brewing, wine and beverages industries.

Other interests

• Structure/function relationships in foods: cereal proteins and polysaccharide gels.
• Structure/function relationships in cork and other lignocellulosic materials.
• Rheological-NMR (rheo-NMR) of polymers: molecular origins of polymer rheological properties.

Mentoring

Summary: 8 Postdocs finished and 1 ongoing; 11 PhD theses finished (8 as supervisor, 2 as co-supervisor) and 7 ongoing; 17 Master theses finished and 3 ongoing; Other researchers: 11 completed and 1 ongoing.

Ongoing supervisions

Post-doctoral researchers

1. Postdoc co-supervision on “Electrical tailoring, and metabolomic assessment, of biocompatible polymers and novel composites to enhance the scaffold actuation in tissue regeneration strategies”, Marisa Maria Viana Maltez da Costa, Universidade de Aveiro(Chemistry and CICECO), FCT SFRH/BPD/111325/2015, from Jan 2016

Doctoral students

1. Researcher (12 months) within project on “Biochemical Impact of Platinum and Palladium-based Anticancer Agents” Ana Rita Araújo, University of Aveiro, Portuguese Science &Technology Foundation (PTDC/QEQ-MED/1890/2014), from April 2018.
2. PhD co-supervision on, “NOVELA: NOVEL food uses for legumes and evaluation of their sensorial and physiological impacts using metabolomics Approaches”, Evla Ferro, Escola Superior de Biotecnologia and Universidade de Aveiro, from November 2017.
3. PhD co-supervision on “Biofluid metabolomics and proteomics for noninvasive biomarker discovery in preterm birth and gestational diabetes: impacting on prenatal diagnosis and offspring health management”, Daniela Duarte, University of Aveiro, FCT SFRH/BD/119509/2016, from 1 July 2017.
4. PhD co-supervision on “IMPULSE: IMpact of a PULSE-based partial replacement diet on household budget, metabolomics and health”,Helena Alexandra Gonçalves Ferreira, School of Biotechnology – Catholic University of Porto and University of Aveiro, SFRH/BD/132240/2017, from 1 October 2017.
5. PhD supervision on “Metabolic biomarkers of chemotherapeutic efficacy of novel and conventional drugs for osteosarcoma: a Nuclear Magnetic Resonance (NMR) metabolomics study”, Ana Sofia Martins, University of Aveiro and University of Coimbra, FCT SFRH/BD/ 111576/2015, from Jan 2016.
6. PhD co-supervision on "The role of the intestine in promoting the lipogenic effects of fructose", João Silva, University of Coimbra and University of Aveiro, FCT SFRH/BD/90250/2012, from 1 Sep 2013.
7. PhD co-supervision on "Metabolomics for the prevention of early carie in children", Joana Leonor Pereira, University of Coimbra and University of Aveiro, from 1 Sep 2015.

Master students

1. Master supervision on “Metabolomics of preterm newborns to assess theoretical term time”, Mariana Rodrigues, University ofAveiro, from Nov 2017.
2. Master co-supervision on “New metabolic markers associated with lung cancer and renal cancer: network analysis”, Fátima Neves, University ofAveiro, from Sep 2015
3. Master/Estagio empresarial on "Food safety and water quality", Raquel Barreira, University ofAveirowith YourLab Company, Aveiro, from Sep 2014.

Other researchers

1. Researcher (6 months) within project on “Biochemical Impact of Platinum and Palladium-based Anticancer Agents” Tatiana Carneiro, University of Aveiro, Portuguese Science &Technology Foundation (PTDC/QEQ-MED/1890/2014), from Jul 2018.

Foreign Collaborators 

• Aix Marseille Université, France; S Caldarelli
• Bruker BioSPin, Germany, M Spraul
• École Normale de Lyon,France; L Emsley
• Harvard Medical School, Retina Service, US; D Husain 
• Imperial College London, UK; J Lindon, J Nicholson and E Holmes
• University of Cambridge, Cancer Research UK – Cambridge Institute; K Brindle
• University of Cambridge, Department of Biochemistry, UK; G Evan
• University of East Anglia, School of Chemistry, UK; P Belton
• University of Manchester, Department of Chemistry, UK; G Morris
• University of Surrey, Department of Chemistry, UK; G Webb
• University of Turku, Finland; H Kallio and K Linderborg
• Claudia Lanari, Laboratory of Hormonal Carcinogenesis, Instituto de Biología y Medicina Experimental (IBYME)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina

National Collaborators

• Catholic University of Porto, School of Biotechnology; M Vasconcelos
• Institute of Biomedical Engineering (INEB), University of Porto, Portugal; M Barbosa
• ITQB NOVA - Instituto de Tecnologia Química e Biológica António Xavier and New University of Lisbon; Helena Santos, ManolisMatzapetakis
• University Hospital of Coimbra, Portugal - Pathological anatomy, Prenatal and Ophthalmology; L Carvalho, I Carreira, MC Almeida, E Galhano, J Murta, R Silva
• University of Coimbra; P Marques, J Jones
• University of Porto; P Guedes
• University of Beira Interior, Covilha, and local Health Centres; C Cruz, I Verde
• iBIMED-Institute of Biomedicine of Aveiro, University of Aveiro; Luisa Helguero

Has taught the following Licenciatura courses:
General Chemistry I and II (lab and exercise classes) / ESB,
Thermodynamics (exercise classes) / ESB,
Structure and Properties of Matter (exercise classes) / UA,
Water Chemistry (exercise classes) / UA,
Chemistry Laboratories (lab classes) / UA,
Food Chemistry II (lab classes/ UA,
Bio-organics (lab classes) / UA,
Food Analysis (theory and lab classes) / UA,
Chemistry I (theory and exercise classes) / UA,
Food Quality and Safet (theory classes), UA
Biochemistry I (theory and exercise classes) UA
Fundaments of Biocehmistry (theory and exercise classes), UA
Biochemistry (theory) UA

Has taught the following Master degree courses:
Food safety and quality (3h theory, Master in Food Biochemistry),
Colloid Chemistry (6 h theory / Master in Chemistry of Natural Products and Foodstuffs, UA,
Solid state NMR (4h theory) / Master in Chemistry of Natural Products and Foodstuffs, UA,
Solid state NMR (2h theory) / Master in Materials Engineering, UA,
Advanced Analytical Techniques for Food Analysis (22 horas), Master in Chemistry of Natural Products and Foodstuffs, UA.

Coordination and Participation in Scientific Projects

Principal Investigator

1. 2018-2021: Project BIOIMPLANT- A Metabolomics-guided Bioreactor for Improved Bone Engineered Implants, (POCI-01-0145-FEDER-031498), CICECO – Aveiro Institute of Materials, supported by the Operational Program Competitiveness and Internalization, in its FEDER/FNR component, and the Foundation for Science and Technology, in its national State Budget component (OE), € 231,382 July 2018 to July 2021.
2. 2014-2015: Project on “Effects of environmental hazards of the Estarreja region on pregnancy metabolism”, funded by CNRS (France)-OHMI Estarreja (Portugal), € 8,000, 6/2014 – 9/2015. PI: University of Aveiro. 
3. 2011-2013: 2^ndScientific Collaboration Agreement between University of Aveiro and Bruker Biospin GmbH on “Metabonomics applications in food analysis and in health”, € 8,940 (human resources) and € 255,330 (software licensing). 
4. 2007-2010: Project on "Metabonomic studies of prenatal disorders by NMR spectroscopy" funded by FCT/PTDC/QUI/66523/2006, € 75,700 (€ 65,000UA), 1/08-6/11, PI: University of Aveiro (29% success rate).
5. 2007-2009: 1^st“Scientific Collaboration Agreement between University of Aveiro and Bruker Biospin GmbH on “Metabonomics applications in food analysis and in health”, € 15,745 (human resources, 1 year PhD student) and € 219,720 (software licensing). 
6. 2005-2008: Project on “Update and expansion of the NMR laboratory of the University of Aveiro”, funded by FCT/CONC-REEQ/934/QUI/2005, € 450,000 and by the University of Aveiro, € 45,000.
7. 2005-2006: Project on “Application of NMR spectroscopy for the chemical characterisation and quality control of beer”, funded by UNICER-Bebidas de Portugal, SGPS, SA (€ 20,425 for UA, PhD student start-up)and Bruker Biospin GmbH (€ 2,250 for UA). 
8. 2003-2007: Project on “NMR and LC-NMR/MS methods for the study of biofluids and biological tissues”, funded by FCT (postdoc grant) and Treaty of Windsor programme (CRUP/British Council), Participants: University of Aveiro and Imperial College, London.
9. 2001-2004: Project on “Structural studies of solid carbohydrates” funded by FCT (POCTI/QUI/33075/99) and co-funded by CRUP/British Council and Universidade de Aveiro (postdoc grant).Participants: University of Aveiro, University of Surrey and University of Warwick, UK, € 37,409 for UA.
10. 1998-2000: Project on "Structural and functional study of wheat flour and its derived foods" funded by PRAXIS XXI (PRAXIS/PCNA/BIO/0703/96), Participants: Universidade de Aveiro, Universidade do Porto, Instituto Superior de Agronomia e Estação Agronómica de Melhoramento de Plantas, Elvas, € 21,360 for UA.
11. 1996-1999:Project on “Synthesis and characterisation of peptides in the solid state”, funded by JNICT (plurianual funding) and Himeji Institute of Technology, Japan. Participants: Universidade de Aveiro and Himeji Institute of Technology, Japan.
12. 1994-1995:Project on "Spectroscopic Investigations of Cereal Proteins Quality", funded by JNICT and Treaty of Windsor (JNICT/British Council). Participants: Universidade de Aveiro, Institute of Food Research and University of Bristol. 

Participant

1. 2016-2024: European project on “Implementation of The Discoveries Centre for Regenerative and Precision Medicine, a new Centre of Excellence in Portugal”, Project ID: 739572 funded underH2020-EU.4.a. - Teaming of excellent research institutions and low performing RDI regions, € 14,996,606.26 (total budget) 01/04/2017-31/03/2024. PI: University of Minho.
2. 2016-2019: Project on “BIOIMPACT-Biochemical Impact of Platinum and Palladium-based Anticancer Agents”, Portuguese Science &Technology Foundation (PTDC/QEQ-MED/1890/2014), € 198,690, 11/7/2016-10/7/2019. PI: University of Coimbra.
3. 2014-2016: Project on “Age-related macular degeneration – can metabolomic profile distinguish progressors?”, Portuguese Science &Technology Foundation (HMSP-IC J/0006/2013), € 97,989, 1/7/2014-30/6/2016. PI: University of Coimbra.
4. 2013-2015: Project on “Biomaterials for Regenerative Medicine”,CENTRO-07-ST24-FEDER-002030,funded by QREN (human resources only), 1/2013 - 6/2015. PI: University of Aveiro.
5. 2012-2015: Project on “Metabolic study of lung cancer and the surgical state: search for metabolic signatures in tissues and biofluids”, funded by CIMAGO, € 1,750 3/12-2/15, PI: University of Aveiro.
6. 2012-2015: Project on “Search for new biomarkers of the response of lung cancer to therapy”, funded by CIMAGO, € 1,750 3/12-2/15, PI: University of Aveiro.
7. 2012-2015: Project on “Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials”, funded byFundação para a Ciência (FCT) e Tecnologia (PTDC/SAU-TOX/120953/2010), € 152,445 (total and UA), 16/4/12-30/3/15, PI: University of Aveiro (14% success rate)
8. 2012-2014: Project on “ASTHMA: Future asthma management helped by non-evasive sampling: contributes for the definition of a rapid and non-evasive diagnostic tool”, funded by FCT/PTDC/QUI-QUI/117803/2010, € 79,688 (total and UA), 1/1/12-31/12/14, PI: University of Aveiro (14% success rate).
9. 2011-2014: Project on “The role of the intestine in promoting the lipogenic effects of fructose”, funded by FCT/PTDC/SAUMET/111398/2009, € 159,564 (€ 20,088 for UA), PI: University of Coimbra.
10. 2008-2011: Project on “Metabolic profiling and biochemical differentiation of human lung tumours by Nuclear Magnetic Resonance (NMR) methods” funded by FCT/PTDC/QUI/68017/2006,€ 70600 (€ 59,000 UA), PI: University of Aveiro(29% success rate).
11. 2008-2011: Project on "Nanochemistry of magnetic/luminescent composites for in vitro medical diagnosis applications" funded by FCT/PTDC/QUI/67712/2006, € 56,200 (total and UA), PI: University of Aveiro.
12. 2007-2010: Project on "Implantable scaffolds for local osteosarcoma chemotherapy", funded by FCT/PTDC/SAU-BEB/66896/2006, € 161,000 (€ 148,000UA), PI: University of Aveiro (29% success rate).
13. 2005-2006: Project “Re-equipment of the laboratory of macromolecular and lignocellulosic materials of the University of Aveiro”, funded by FCT/CONC-REEQ/584/CTM/2005, €100,000 and by the University of Aveiro, €10,000. 
14. 2005-2008: Project on “Mould proteome regulation by substrate bioavailability: depolymerising enzymes likely to alter biopolymer nanostructure.”, funded by FCT/POCI/QUI/56229/2004, € 198,000 (total budget), PI: Institute for Experimental and Technological Biology - Lisbon(36% success rate).
15. 2003-2005: Project on “Cellulose: surface properties, interaction with binding domains and enzymatic modification” funded by FCT/POCTI/QUI/44368/2002, € 4,250 for UA, PI: University of Minho.
16. 2001-2004: Project on "Structural and Functional Aspects of Bulk and Interfacial Polysaccharide-Surfactant Interactions in Food Colloids" funded by FCT/POCTI/BIO/33626/99, € 139,660 (total and UA), PI: University of Aveiro.
17. 2003-2004: Project on “Study of the viscoelastic properties of flours: correlation between extensibility and chemical composition”, funded by CRUP/British Council.
18. 1997-2000: Project on "From Eucalyptus globulusto paper: kraft pulp bleaching" funded by PRAXIS XXI (3/3.2/PAPEL/2326/95) and paper company RAIZ.
19. 1997-2000: Project "From Eucalyptus globulusto paper: kraft pulping", funded by PRAXIS XXI (3/3.2/PAPEL/2327/95) and paper company RAIZ.
20. 1996-1999: Project on "Improving the quality of EU wheats for use in the food industry", funded by EC FAIR (Ref. CT96 1170) and co-funded by JNICT/British Council). Participants: IACR-Long Ashton Research Station-UK, Institute of Food Research-UK, Universidade de Groningen-NL, Universidade de Lund-SW, Universidade de Tuscia-IT, University of Aveiro-PT, Svalöf Weibull AB-SW, INRA-FR, Universidade de Catania-IT, IACR-Rothamsted-UK, € 87,434 euros for UA.

Artigos SCI nos últimos 5 anos:

1. Graça G,Moreira AS, Vicente Correia AJ, Goodfellow BJ, Barros AS, Duarte IF,Carreira IM, Galhano E,Pita C, Almeida MC, Gil AM, “Mid-infrared (MIR) metabolic fingerprinting of amniotic fluid: a possible avenue for early diagnosis of prenatal disorders?” Analytica Chimica Acta, 764 24-31, 2013. doi:10.1016/j.aca.2012.12.023
2. Diaz SD, Barros AS, Goodfellow BJ, Duarte IF, Carreira IC, Galhano E, Pita C, Almeida MC, Gil AM, “Following Healthy Pregnancy by Nuclear Magnetic Resonance (NMR) Metabolic Profiling of Human Urine”, Journal of Proteome Research, 12 969-979, 2013. doi: 10.1021/pr301022e
3. Lehtonen H-M, Lindstedt A, Järvinen R, Sinkkonen J, Graça G, Viitanen M, Kallio H. Gil AM, “¹H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal”, Food Chemistry,138 (2-3), 982-990, 2013. doi: 10.1016/j.foodchem.2012.10.081* 
4. Diaz S, Barros A, Goodfellow B, Duarte I, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Second trimester maternal urine for the diagnosis of trisomy 21 and prediction of poor pregnancy outcomes”, Journal of Proteome Research, 12(6), 2946-2957, 2013. doi:10.1021/pr4002355Cover of the June 2013 Issue.
5. Duarte IF, Rocha CM, Gil AM, “Metabolic profiling of biofluids: potential in lung cancer screening and diagnosis” Expert Review of Molecular Diagnostics,13(7), 737–748, 2013. doi: 10.1586/14737159.2013.835570
6. Duarte IF, Ladeirinha AF, Lamego IL, Gil AM, Carvalho L, Carreira IM, Melo JB, “Potential markers of cisplatin treatment response unveiled by NMR meabolomics of human lung cells”, Molecular Phamaceutics, 10(11),4242-4251, 2013.doi: 10.1021/mp400335k *
7. Loureiro CC, Gomes J, Barros A, Gil AM, Carrola J, Duarte IF, Bousquet J, Todo-Bom A, Rocha SM, “Urinary metabolomic changes as a predictive biomarker of asthma exacerbation”,The Journal of Allergy and Clinical Immunology, 133 (1), 261-263.e5, 2014.doi:10.1016/j.jaci.2013.11.004 *
8. Duarte IF, Diaz S, Gil AM, “NMR metabolomics of human blood and urine in disease research”, Journal of Pharmaceutical and Biomedical Analysis, 93, 17–26, 2014. doi: http://dx.doi.org/10.1016/j.jpba.2013.09.025
9. Dias MC, Figueiredo P, Duarte I, Gil A, Santos C. "Differential response of young and expanded lettuce leaves to fungicide mancozeb: chlorophyll fluorescence, lipid peroxidation, pigments and proline content", Photosynthetica, 52(1), 148-151, 2014. doi:10.1007/s11099-014-0016-y *
10. Lindstedt A, Järvinen R, Sinkkonen J, Lehtonen H-M, Graça G, Viitanen M, Gil AM, Kallio H, “Postprandial response on fatty meal is affected by sea buckthorn (Hippophaë rhamnoides) supplementation: NMR metabolomics study”, Food Research International, 58, 23-34, 2014. doi:10.1016/j.foodres.2013.12.010*
11. Pinto J, Domingues MRM, Galhano E, Pita C, Almeida MC, Carreira IM, Gil AM, “Human plasma stability during handling and storage: impact on NMR metabolomics”, Analyst,139 (5), 1168 – 1177, 2014. doi: 10.1039/c3an02188b. 
12. Pereira SI, Figueiredo PI, Barros AS, Dias MC, Santos C, Duarte IF, Gil AM, “Changes in the metabolome of lettuce leaves due to exposure to mancozeb pesticide”, Food Chemistry, 154, 291-298, 2014. doi: 10.1016/j.foodchem.2014.01.019
13. Carregosa V, Figueira E, Gil AM, Pereira S, Pinto J, Soares AMVM, Freitas R, “Tolerance of Venerupis philippinarumto salinity: osmotic and metabolic aspects.”, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 171, 36-43. 1531-4332, 2014. doi:10.1016/j.cbpa.2014.02.009*
14. Lima MRM, Diaz S, Lamego, I, Grusak MA, Vasconcelos MW, Gil AM,  “Nuclear Magnetic Resonance (NMR) Metabolomics of Iron Deficiency in Soybean Leaves”, Journal of Proteome Research, 13(6),3075-3087, 2014. doi: 10.1021/pr500279f
15. Pinto J, Maciel E, Melo T, Domingues MRM, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Maternal plasma phospholipids are altered in trisomy 21cases and prior to preeclampsia and preterm outcomes”, Rapid Communications in Mass Spectrometry, 28(14), 1635-1638, 2014.
16. Lamego I, Duarte I, Marques MPM, Gil AM, “Metabolic markers of osteosarcoma response to doxorubicinand methotrexate treatment: comparison to cisplatin”, Journal of Proteome Research, 13, 6033−6045,2014.doi:10.1021/pr500907d
17. Rocha CM, Barros AS, Goodfellow BJ, Carreira IM, Gomes A, Sousa A, Bernardo J, Carvalho L, Gil AM, Duarte IF, “NMR metabolomics of human lung tumours reveals distinct metabolic signatures for adenocarcinoma and squamous cell carcinoma”, Carcinogenesis, 36 (1), 68-75, 2015. doi: 10.1093/carcin/bgu226 *
18. Pinto J, Barros A, Domingues MR, Goodfellow BJ, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine”, Journal of Proteome Research, 14, 1263-1274, 2015. doi: 10.1021/pr5011982
19. Pinto J, Almeida L, Martins A, Duarte D, Barros A, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, “Prediction of gestational diabetes through NMR metabolomics of maternal blood”, Journal of Proteome Research, 14(6), 2696–2706, 2015. doi: 10.1021/acs.jproteome.5b00260
20. Pinto J, Almeida L, Martins A, Duarte D, Domingues MR, Barros A, Galhano E, Pita C, Almeida MC, Carreira I, Gil AM, ”Impact of fetal chromosomal disorders impact on maternal blood metabolome: towards new biomarkers?”, American Journal of Obstetrics and Gynecology, 213 (6), 1.e1-1.e15, 2015. doi:10.1016/j.ajog.2015.07.032
21. Gil AM, Guedes P, Monteiro MS, Duarte IF, “NMRmetabolomics of renal cancer: an overview”, Bioanalysis, Special Report, 7(18), 2361–2374, 2015. doi: 10.4155/bio.15.167
22. Carrola J, Bastos V, Oliveira JMPF, Oliveira H, Santos C, Barros AS, Gil AM, Duarte IF, “Insights into the impact of silver nanoparticles on human keratinocytes metabolism through NMR metabolomics”, Archives of Biochemistry and Biophysics, 589, 53-61, 2016. doi: 10.1016/j.abb.2015.08.022*
23. Diaz SO and Pinto J, Barros AS, Morais E, Duarte D, Negrao F, Pita C, Almeida MC, Carreira IM, Spraul M, Gil AM, “Newborn urinary metabolic signatures of prematurity and other disorders: a case control study”, Journal of Proteome Research, 15(1), 311–325, 2016. doi: 10.1021/acs.jproteome.5b00977
24. Carrola J, Bastos V, Jarak I, Oliveira-Silva R, Malheiro E, Daniel da Silva AL, Oliveira H, Santos C, Gil AM, Duarte IF, “Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure-activity relationships and role of ionic silver and oxidative stress”, Nanotoxicology, 10(8), 1105-17, 2016.doi: 10.1080/17435390.2016.1177744*
25. Pinto J, Diaz SO, Aguiar E, Duarte D, Barros AS, Galhano E, Pita C, Almeida MC, Carreira IM, Spraul M, Gil AM, “Metabolic profiling of maternal urine can aid clinical management of Gestational Diabetes Mellitus”, Metabolomics, 2016,12, article no. 105. doi: 10.1007/s11306-016-1046-1
26. Vasconcelos DM, Gonçalves RM, Almeida CR, Pereira IO, Oliveira MI, Neves N, Silva AM, Ribeiro AC, Cunha C, Almeida AR, Ribeiro CC, Gil AM, Seebach E, Kynast KL, Richter W, Lamghari M, Santos SG, Barbosa AM,“Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration”, Biomaterials, 111, 163-178, 2016. doi: 10.1016/j.biomaterials.2016.10.004. *
27. Monteiro MS, Barros AS, Pinto J, Carvalho M, Pires-Luís AS, Jerónimo C, Henrique R, Bastos ML, Gil AM and Pinho PG (equal contribution of last 2 authors), “Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma”, Scientific Reports – Nature Publishing Group, 6, Article number: 37275, 2016.
28. Lamego I, Marques MPM, Duarte IF, Martin AS, Oliveira H, Gil AM, “Impact of the Pd₂Spermine chelate on osteosarcoma metabolism: an NMR metabolomics study”, Journal of Proteome Research,16(4), 1773-1783, 2017. http://dx.doi.org/10.1021/acs.jproteome.7b00035
29. Monteiro M, Moreira N, Pinto J, Pires-Luís AS, Henrique R, Jerónimo C, Bastos ML, Gil AM, Carvalho M, Guedes de Pinho M, “GC-MSmetabolomics-based approach for the identification of a potential VOC-biomarker panel in the urine of Renal Cell Carcinomapatients”, Journal of Cellular and Molecular Medicine, 21 (9), 2092-21052017, 2017. doi: 10.1111/jcmm.13132
30. Lains, I., Duarte, D., Barros, A.S., Martins, A.S., Gil, J., Miller, J.B., Marques, M., Mesquita, T., Kim, I.K., Cachulo, M.L., Vavvas, D., Carreira, I.M., Murta, J.N., Silva, R., Miller, J.W., Husain, D., Gil, A.M., “Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy”, PLOS ONE, 12(5): e0177749, 2017. https://doi.org/10.1371/journal.pone.0177749
31. Jarak I, Carrola J, Barros AS, Gil AM, Pereira ML, Corvo ML, Duarte IF, “Metabolism Modulation in Different Organs by Silver Nanoparticles: An NMR Metabolomics Study of a Mouse Model”, Toxicological Sciences, 159(2), 422-435, 2017. doi: 10.1093/toxsci/kfx142 *
32. Gil AM, Duarte D, “Biofluid metabolomics in preterm birth research”, Reproductive Sciences, 2018, in press. doi: 10.1177/1933719118756748
33. Gil AM, Duarte D., Pinto J, Barros AS, “Assessing exposome effects on pregnancy through urine metabolomics of a Portuguese (Estarreja) cohort”, Journal of Proteome Research, 17(3), 1278-1289, 2018. doi: 10.1021/acs.jproteome.7b00878
34. Carrola J, Pinto R, Nasirpour M, Freire C, Gil AM, Santos C, Oliveira H, Duarte I,NMR metabolomics reveals metabolism-mediated protective effects in liver (HepG2) cells exposed to sub-toxic levels of silver nanoparticles", Journal of Proteome Research, 17(4), 1636-1646, 2018, doi: 10.1021/acs.jproteome.7b00905
35. Gil AM, Fernandes MH, Duarte IF, Metabolomics in Biomaterial Research, in Narayan R (Ed), Encyclopedia of Biomedical Engineering, vol 3, pp. 432-442, Elsevier, 2019, ISBN: 9780128048290, doi: 10.1016/B978-0-12-801238-3.10888-8 
36. Silva JCP, Mota M, Matins FO, Nogueira C, Gonçalves T, Carneiro T, Pinto J, Duarte D, Barros AS, Jones JG, Gil AM, Intestinal microbial and metabolic profiling of mice fed with high-glucose and high-fructose diets, Journal of Proteome Research, 17(8), 2880-2891, 2018. Doi: 10.1021/acs.jproteome.8b00354