CICECO » João Mano

Short CV

João F. Mano, PhD in Chemistry (1996, Technical Univ. Lisbon), D.Sc. in Tissue Engineering Regenerative Medicine and Stem Cells (2012, Univ. Minho), is a full professor at the Department of Chemistry of the University of Aveiro (Portugal). During his career he has been teaching courses related to biomaterials/polymer science and technology, and tissue engineering, in both undergraduate and graduate levels. He is the director of the Doctoral Program on Biotechnology at the Univ. of Aveiro. He has also an appointment as Invited Professor (classe exceptionelle, since 2014) at University of Lorraine (France), and Visiting Professor in KAIST (South Korea) - 2019 and Adjunct Professor at Ajou University (South Korea) since 2020.

Since 2022 he is a vice-director at CICECO – Aveiro Institute of Materials, where he is directing the COMPASS Research Group, founded in April 2016. His research focuses on the application of advanced biomaterials and cells to advance multidisciplinary concepts in the field of regenerative and personalized medicine. Specifically, he utilizes biomimetic and nano/micro-technology approaches to develop polymer-based biomaterials and surfaces for the creation of biomedical devices with enhanced structural and multi-functional properties. He also engineers microenvironments to regulate cell behavior and organization, with the goal of clinically applying these technologies in advanced therapies and drug screening, or in the bioengineering of disease models.

João F. Mano is author of 750+ original research or review papers in international journals (36000+ citations, h=96 – Web of Science) and 40+ book chapters. João F. Mano co-edited 9 special issues in international journals and 5 books. João F. Mano has been invited to review manuscripts from 340+ different international journals and to routinely evaluate projects from numerous private and state funding agencies from 19 different countries. He was the LS9 panel chair for the peer review ERC Advanced Grants (2020-2023). João F. Mano supervised or co-supervised 74+ MSc, 26 PhD students, and 40+ post-doctoral fellows. He filed 12 patents (8 as senior inventor). João F. Mano is the co-founder and chairman of: METATISSUE (2018), a company developing human-derived hydrogels for 3D cells culture (5 prizes and owner of two patents); and CELLULARIS Biomodels (2021), a company offering services for cell-based disease models (1 prize and 1 patent).

He is the Editor-in-Chief of Materials Today Bio (Elsevier). He has been also part of a series of scientific societies and editorial boards of 12 international journals. He has been coordinating or involved in many national and European research projects and participated in the organization of scientific events in the area of polymer/materials science and biomaterials/tissue engineering.

Professor João F. Mano has been member of scientific committees, organizing committees, referee and chairman in different international meetings. He was invited to present more than 120 invited/keynote/plenary talks in international conferences including EUROMAT, ESTAC, TERMIS (EU and AP chapters and World conferences), BIOMED, FBPS, NANOMED, COLAOB, ESB, SFB, World Biomaterials Conference, E-MRS, ESAO, EPF, ACS, CBECIMAT, NICE, Inter. HYMA, APME, APCChE, PPM, EPNOE, SELECTBIO, EFB, CRS, ECMNP, PAT, BioIberoamerica, RRB, ScSB, EuChemS, BPP.

João F. Mano has received different honours and awards: (i) fellow of the IUPAC (International Union of Pure

and Applied Chemistry) since 2004; (ii) the Stimulus to Excellence Award by the Portuguese Minister for Science and Technology in 2005; (iii) the Materials Science and Technology Prize, attributed by the Federation of European Materials Societies (FEMS) in 2007 (iv) UNESCO Chair on Biomaterials attributed in 2008 from the University of Havana (Cuba); (v) the major BES innovation award in 2010 (at that time, one of the most recognised innovation prize in Portugal); (vi) recipient an Advanced Grant from the European Research Council (ERC-AdG), in 2015; (vii) received the title of Professor@Lorraine from the University of Lorraine, France, in 2018; (viii) recipient a Proof of Concept Grant from the European Research Council (ERC-PoC), in 2018; (ix) received the title of Doctor Honoris Causa, given by University of Lorraine, in 2019; (x) awarded with a Gutenberg Chair, supported by the Great East Region of France, in 2020; (xi) recipient a second ERC-AdG, in 2020; (xii) recipient a second ERC-PoC, in 2020; (xiii) elected fellow of the European Academy of Sciences (FEurASc); (xiv) Bluepharma | University of Coimbra Innovation Award 2019; (xv) Inducted Fellow Biomaterials Science and Engineering (FBSE) in 2020; (xvi) Researcher Award University of Aveiro 2020 (first edition); (xvii) George Winter Award 2020: European Society for Biomaterials. (xviii) Madinaveitia-Lourenço Prize, from the Spanish Royal Society of Chemistry, 2021. (xix) elected fellow of the American Institute of Medical and Biological Engineering (FAIMBE), 2022; (xx) received the title of Doctor Honoris Causa, given by University of Utrecht, in 2022.

Background

◊ Habilitation in Tissue Engineering, Regenerative Medicine and Stem Cells (Univ. of Minho) - 2012

◊ PhD in Chemistry (Technical University of Lisbon) - 1996

◊ Chemical Engineering degree (I.S.T.) - 1992.

Research Area

- Bio-inspired materials: We take nature as a source of endless inspiration for the development of novel classes of polymer-based materials and processes, combining chemistry, materials science, and engineering tools.

- Cell and Tissue Engineering: Tissue engineering addresses the scarcity of tissues/organs available for repair and transplantation, by adopting multidisciplinary strategies permitting the ex-vivo creation of implantable hybrid constructs through the integration of biomaterials, therapeutic cells and physicochemical signals.

- Nano/micro platforms for biomedicine: Our group focuses on the use of an interplay and cutting-edge nano- and micro-technologies for addressing a multitude of biomedical applications, including those in diagnostics and therapy.

(http://compass.web.ua.pt/research-areas/)

Representative Publications (last 5 years)

1- S.C. Santos, C.A. Custódio, J.F. Mano - Photopolymerizable platelet lysate hydrogels for customizable 3D cell culture platforms. Advanced Healthcare Materials, 7, 1800849 (2018).

2- L.F. Santos, A.S. Silva, C.R. Correia, J.F. Mano - Physical immobilization of particles inspired by pollination. Proceedings of the National Academy of Sciences (USA), 116(12), 5405 (2019).

3- A.R. Sousa, C.M. Cruz, M.B. Oliveira, J.F. Mano - One‐step rapid fabrication of cell‐only living fibers. Advanced Materials, 32(2), 1906305 (2020).

4- A.S. Silva, L.F. Santos, M.C. Mendes, J.F. Mano - Multi-layer pre-vascularized magnetic cell sheets for bone regeneration. Biomaterials 231, 1196648 (2020).

5- C.F. Monteiro, S.C. Santos, C.A. Custódio, J.F. Mano – Human platelet lysates-based hydrogels: a novel personalized 3D platform for spheroid invasion assessment. Advanced Science 7 (7), 1902398 (2020).

6- I.M. Bjørge, M. Salmeron-Sanchez, C.R. Correia, J.F. Mano - Cell behavior within nanogrooved sandwich culture systems. Small, 16 (31), 2001975 (2020).

7- M.D. Neto, A. Stoppa, M.A. Neto, F.J. Oliveira, M.C. Gomes, A.R. Boccaccini, P.A. Levkin, M.B. Oliveira, J.F. Mano - Fabrication of quasi-2D shape-tailored microparticles using wettability contrast-based platforms. Advanced Materials, 33(14), 2007695 (2021).

8- M.M. Maciel, T.R. Correia, V.M. Gaspar, J.M.M. Rodrigues, I.S. Choi, J.F. Mano - Partial coated stem cells with bioinspired silica as new generation of cellular hybrid materials. Advanced Functional Materials, 31(29), 2009619 (2021).

9- M. Zargarzadeh, A.S. Silva, C. Nunes, M.A. Coimbra, C.A. Custódio, J.F. Mano - Self-glucose feeding hydrogels by enzyme empowered degradation for 3D cell culture. Materials Horizons, 9(2), 694-707 (2022).

10- R.C. Gonçalves, S. Vilabril, C.M.S.S. Neves, M.G. Freire, J.A.P. Coutinho, M.B. Oliveira, J.F. Mano - All-aqueous freeform fabrication of perfusable self-standing soft compartments. Advanced Materials, 34(31), 2200352 (2022).

[see complete list of publications in http://www.researcherid.com/rid/A-4418-2009]

João Mano

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Últimas Notícias

Short CV

Background

Research Area

Representative Publications (last 5 years)

Supervisões em Curso

Projectos

Ativação metabólica da diferenciação 3D de células estaminais em tecido ósseo (Better Bone)

ParticipanteFundação para a Ciência e a Tecnologia

Bioengenharia de dispositivos híbridos hierárquicos com capacidade de auto oxigenação (O2CELLS)

CoordenadorFundação para a Ciência e a Tecnologia

CICECO – Instituto de Materiais de Aveiro (UIDP/50011/2020)

ParticipanteFundação para a Ciência e a Tecnologia

CICECO – Instituto de Materiais de Aveiro (UIDB/50011/2020)

ParticipanteFundação para a Ciência e a Tecnologia

Desenvolvimento de termometria sem fios a 4D tendo como alvo a ablação de tumores (PTDC/NAN-MAT/3901/2020)

ParticipanteFundação para a Ciência e a Tecnologia

Exploração do Potencial Regenerativo e Translacional de Fibras Celulares (CellFi)

ParticipanteFundação para a Ciência e a Tecnologia

Full human-based multi-scale constructs with jammed regenerative pockets for bone engineering. (REBORN)

CoordenadorEuropean Comission

Human based bioinks to engineer physiologically relevant tissues (HumanINK)

CoordenadorEuropean Comission

Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)

CoordenadorEuropean Comission

Innovative tools to treat and model complex cancer environments (TheraTools)

Coordenador LocalEuropean Comission

Laboratório Associado CICECO-Instituto de Materiais de Aveiro (LA/P/0006/2020)

ParticipanteFundação para a Ciência e a Tecnologia

Merging Sustainable and Digital Chemical Technologies for The Development of Greener-Bydesign Pharmaceuticals (SusPharma)

Coordenador LocalEuropean Comission

Mosaicos bioinspirados para o desenvolvimento de microtecidos ósseos ultra-estruturados; (TETRISSUE)

ParticipanteFundação para a Ciência e a Tecnologia

PRInted Symbiotic Materials as a dynamic platform for Living Tissues production (PRISM-LT)

Coordenador LocalEuropean Comission

A bioactivated nano-layered hydrogel for dermal regeneration in hard-to-heal ulcers (BioNaNor)

Coordenador LocalOther International

Bioengineered autonomous cell-biomaterials devices for generating humanised micro- tissues for regenerative medicine (ATLAS)

CoordenadorEuropean Comission

Biopolímeros de origem marinha como blocos de construção inovadores do mar para o desenvolvimento de membranas bioreabsorvíveis multicamada para regeneração guiada de osso (BLUETEETH)

CoordenadorFundação para a Ciência e a Tecnologia

Biorrefinaria de microalgas Coccolithophore: uma abordagem para biomateriais sustentaveis (Coccolitho4BioMat)

ParticipanteFundação para a Ciência e a Tecnologia

BLUEGLUE – Adesivos médicos bioinspirados em biopolímeros derivados de macroalgas marinhas (BLUEGLUE)

CoordenadorOther National

Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)

ParticipanteFundação para a Ciência e a Tecnologia

Colonizacao 3D de celulas em hidrogeis de origem marinha atraves de padronizacao por microcanais para regeneracao ossea (PROMENADE)

ParticipanteFundação para a Ciência e a Tecnologia

Desenvolvimento de hidrogeis de inspiracao marinha multifuncionais e de elevado desempenho para regeneracao de cartilagem, reticulados com ligacoes nao-covalentes e bio-instrutivas deslizantes. (MARGEL)

CoordenadorFundação para a Ciência e a Tecnologia

Desenvolvimento de uma membrana periodontal multicamada composta por blocos inovativos a base de polimeros de origem marinha e enzima para regeneracao guiada de osso que possui mineralizacao enzimatica controlada. (MIMETIc)

ParticipanteFundação para a Ciência e a Tecnologia

Dispositivos Supramoleculares Auto-Regulados baseados na Complementaridade dos Pares de Base do ADN: Uma Tecnologia Biomimética e com Reconheciemnto Molecular para Isolar Células Específicas para Aplicações Biomédicas (SUPRASORT)

ParticipanteFundação para a Ciência e a Tecnologia

Enabling precision chemical methodologies applied to natural -based systems for the development of multifunctional biomedical devices (CHEM2NATURE)

Coordenador LocalEuropean Comission

European Network of Bioadhesion Expertise: Fundamental Knowledge to Inspire Advanced Bonding Technologies (COST Action CA15216)

Coordenador LocalEuropean Comission

Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models (AMNIOGEL)

CoordenadorEuropean Comission

Hidralazina - uma nova abordagem terapêutica no Carcinoma da próstata resistente à castração (HyTherCaP)

Coordenador LocalFundação para a Ciência e a Tecnologia

Hidrogéis de Lisados de Plaquetas para Regeneração do Miocárdio (BEAT)

ParticipanteFundação para a Ciência e a Tecnologia

Metodologias eficientes para a conjugação de polissacarídeos naturais com péptidos para obtenção de membranas multifuncionais para regeneração periodontal. (COP2P)

ParticipanteFundação para a Ciência e a Tecnologia

Novel 3D platforms to engineer bone microtissues for in vitro disease models; (Microbone)

CoordenadorEuropean Comission

Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)

ParticipanteFundação para a Ciência e a Tecnologia

Regeneração Óssea Orquestrada pela Interação de Células do Sistema Imunitário com Microlaboratórios de Células e Microplataformas Padronizadas (CIRCUS)

ParticipanteFundação para a Ciência e a Tecnologia

Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus:a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche (ELASTISLET)

Coordenador LocalEuropean Comission