Ongoing Supervisions
Projects
Improving the manufacturing of mRNA vaccines applying ionic liquids and integrated production-clarification processes (mVACCIL)
PartnerFundação para a Ciência e a Tecnologia
Nova abordagem terapêutica para desacelerar a progressão da doença de Parkinson; (PDSolve)
Local CoordinatorIndustry National
A doença de Parkinson (DP) é a segunda doença neurodegenerativa mais prevalente no mundo, com profundos impactos económicos e sociais. O objetivo deste projeto é provar a eficácia farmacológica e aplicação terapêutica à...Aeration of multiphase biological reactors (POCTI/EQU/44427/2002)
PartnerFundação para a Ciência e a Tecnologia
Biological reactors Aeration Multiphase PerfluorocarbonsAnchoring Basic Parameters for fundamental predictive models in Liquid Salt Systems (PTDC/QUI/72903/2006)
PartnerFundação para a Ciência e a Tecnologia
Ionic Liquids Vapor Pressure Enthalpy of vaporization Vapor Liquid EquilibriumAplicação de SAB constituídos por líquidos iónicos no desenvolvimento de diagnósticos de câncer do sistema adrenalina (MCT/CNPq 14/2010 Universal)
Local CoordinatorOther International
DeepBiorefinery - Natural Deep Eutectic Solvents: A platform to Boost Eucalyptus globulus and Quercus suber cork integrated Biorefinerie (DeepBiorefinery )
PartnerFundação para a Ciência e a Tecnologia
natural deep eutetic solvents, biorefinery, green separation processesDesenvolvimento de nanomateriais sustentáveis para a purificação de fármacos anti-leucémicos (NanoPurAsp)
PartnerFundação para a Ciência e a Tecnologia
Development of a sustainable technology for the extraction and purification of chlorophylls from biomass (EXPL/QEQ-PRS/0224/2013 )
PartnerFundação para a Ciência e a Tecnologia
chlorophyll extraction bioresources ionic liquidsDevelopment of Ionic-Liquid-based Devices for the Removal of Cytostatic Drugs From Urine Excreted by Cancer Patients (IonCytDevice)
CoordinatorFundação para a Ciência e a Tecnologia
Development of New Oxygen Therapeutics using Fluorinated Ionic Liquids (PTDC/EQU-FTT/118800/2010)
Local CoordinatorFundação para a Ciência e a Tecnologia
Fluorinated Ionic Liquids Perfluoroalkanes Phase Equilibria Oxygen SolubilityEquilibrium and Interfacial Properties of Water + Oil Systems (POCI/EQU/58239/2004)
PartnerFundação para a Ciência e a Tecnologia
Phase Equilibria Interfacial Tension Aqueous Systems ModelingEXIL - Exchange on Ionic Liquids (EXIL)
PartnerEuropean Comission
The objective of this Action is to coordinate European research activities and knowledge exchange on ionic liquids (ILs, low melting salts, many of them liquid at room temperature and below) and to explore their full potential in the context of fundamental and applied chemistry, materials science and engineering. The COST Action will provide a c...Extraction and Purification of Biomolecules (FAPITEC/FUNTEC/CNPq n. 10/2011)
Local CoordinatorOther International
Igy Technology: A Purication Platform using Ionic-Liquid-Based Aqueous Biphasic Systems (IGYPURTECH)
CoordinatorEuropean Comission
With the emergence of antibiotic-resistant pathogens the development of antigen-specific antibodies for use in passive immunotherapy is, nowadays, a major concern in human society. Despite the most focused mammal antibodies, antibodies obtained from egg yolk of immunized hens, immunoglobulin Y (IgY), are an alternative option that can be obtaine...Ionic liquid-based supports for pre-miRNAs purification targeting Alzheimer's disease (PUREmiRSILs)
Local CoordinatorFundação para a Ciência e a Tecnologia
Ionic Liquids as Promoters of Aqueous Biphasic Systems: The Role of van der Waals and Coulomb Interactions (PTDC/QUI-QUI/121520/2010)
PartnerFundação para a Ciência e a Tecnologia
Aqueous Biphasic System Ionic Liquid Inorganic Salt PolymerMultiBiorefinery - Multi-purpose strategies for broadband agro-forest and fisheries by-products valorization: a step forward for a truly integrated biorefinery (SAICTPAC/0040/2015)
PartnerFundação para a Ciência e a Tecnologia
Nanostructured ZnO and ZnO/nanocarbon composites for biosensing applications (NANOBIOSENSE)
PartnerFundação para a Ciência e a Tecnologia
The expanding interest regarding biosensing and early diseases’ diagnosis has led to an exponential growth of R&D efforts in order to find the most suitable materials and sensing mechanisms to achieve high sensitivity and selectivity at low production cost. In this framework, the present project envisages the development of ZnO-based nanostructu...Optimization and Scale-up of Novel Ionic-Liquid- based Purification Processes for Recombinant Green Fluorescent Protein produced by Escherichia coli (FAPESP/19793/2014)
PartnerFundação para a Ciência e a Tecnologia
biopharmaceuticals, fluorescent proteins, purification, aqueous biphasic systemsSGH : Smart Green Homes (Smart Green Homes)
PartnerIndustry National
The Smart Green Homes (SGH) Project aims to develop integrated product and technology solutions for the households, raising standards of comfort, safety and user satisfaction to a new level and, at the same time, to respond to the problems of sustainability of the Planet, increasing the energy efficiency and reducing the emission of gaseous poll...The best of two worlds: Ionic liquids as Active Pharmaceutical Ingredients (PTDC/EQU-EPR/104554/2008)
Local CoordinatorFundação para a Ciência e a Tecnologia
Ionic Liquids Fluoroquinolones Bioavailability Solubility related propertiesTowards the improvement of recombinant proteins bioprocessing using ionic liquids (IL2BioPro)
PartnerFundação para a Ciência e a Tecnologia
Towards the use of IgY antibodies as alternative therapeutics (PureIgY)
CoordinatorEuropean Comission
Immunoglobulins (or antibodies) are molecules produced by our white blood cells; the immunoglobins recognise 'invaders' and aid in their destruction. Humans make five different classes, one of which is similar in function to IgY, an unusual antibody made by chickens. The circulating IgY accumulates in the yolk of chicken eggs. This is convenient...Vapour Liquid Equilibrium of Pure Ionic Liquids and their Mixtures with Organic Solvents (PTDC/EQU-FTT/65252/2006)
PartnerFundação para a Ciência e a Tecnologia
Ionic Liquids Vapour pressure Molar enthalpies and entropies of vaporization Vapour Liquid equilibriumPublications
Advances in aqueous biphasic systems for
Magalhaes, FF; Tavares, APM; Freire, MG
2021, CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY, 27.
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Unveiling Modifications of Biomass Polysaccharides during Thermal Treatment in Cholinium Chloride : Lactic Acid Deep Eutectic Solvent
Morais, ES; Lopes, AMD; Freire, MG; Freire, CSR; Silvestre, AJD
2021, CHEMSUSCHEM, 14, 2, 686-698.
ISBN:
1864-564X
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Advances Achieved by Ionic-Liquid-Based Materials as Alternative Supports and Purification Platforms for Proteins and Enzymes
Bento, RMF; Almeida, CAS; Neves, MC; Tavares, APM; Freire, MG
2021, NANOMATERIALS, 11, 10.
ISBN:
2079-4991
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Integrated Production and Separation of Furfural Using an Acidic-Based Aqueous Biphasic System
Morais, ES; Schaeffer, N; Freire, MG; Freire, CSR; Coutinho, JAP; Silvestre, AJD
2021, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 9, 36, 12205-12212.
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Nucleophilic degradation of diazinon in thermoreversible polymer-polymer aqueous biphasic systems
Millan, D; Almeida, MR; Rufino, AFCS; Coutinho, JAP; Freire, MG
2021, PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 23, 7, 4133-4140.
ISBN:
1463-9084
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25th Anniversary of Molecules-Recent Advances in Green Chemistry
de Gonzalo, G; Freire, MG
2021, MOLECULES, 26, 12.
ISBN:
1420-3049
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Interferon-Based Biopharmaceuticals: Overview on the Production, Purification, and Formulation
Castro, LS; Lobo, GS; Pereira, P; Freire, MG; Neves, MC; Pedro, AQ
2021, VACCINES, 9, 4.
ISBN:
2076-393X
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Opposite Effects Induced by Cholinium-Based Ionic Liquid Electrolytes in the Formation of Aqueous Biphasic Systems Comprising Polyethylene Glycol and Sodium Polyacrylate
Bernardo, SC; Capela, EV; Pereira, JFB; Ventura, SPM; Freire, MG; Coutinho, JAP
2021, MOLECULES, 26, 21.
ISBN:
1420-3049
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L-asparaginase production review: bioprocess design and biochemical characteristics
Castro, D; Marques, ASC; Almeida, MR; de Paiva, GB; Bento, HBS; Pedrolli, DB; Freire, MG; Tavares, APM; Santos-Ebinuma, VC
2021, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 105, 11, 4515-4534.
ISBN:
1432-0614
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Enhancing Artemisinin Solubility in Aqueous Solutions: Searching for Hydrotropes based on Ionic Liquids
Sales, I; Abranches, DO; Costa, P; Sintra, TE; Ventura, SPM; Mattedi, S; Coutinho, JAP; Freire, MG; Pinho, SP
2021, FLUID PHASE EQUILIBRIA, 534.
ISBN:
1879-0224
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Waste Valorisation Using Ionic Liquids

Francisca e Silva; Ana Sousa; Mara Freire; João Coutinho
2022, Royal Society of Chemistry.
ISBN:
978-1-83916-468-2
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Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications

Mara G. Freire
2016, 315, Berlin , Springer Berlin Heidelberg.
ISBN:
978-3-662-52875-4
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Anti-Cancer Biosurfactants

In Springer (Eds.), Microbial Biosurfactants
Flávia F. Magalhães, João C. F. Nunes, Marília T. Araújo, Ana M. Ferreira, Mafalda R. Almeida, Mara G. Freire, Ana P. M. Tavares
2021, 159-196.
ISBN:
10.1007/978-981-15-6607-3_8
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Recovery and Purification of (Bio)Pharmaceuticals Using (Nano)Materials

In Bentham Science (Eds.), Recent Advances in Analytical Techniques Volume: 4
Ana P. M. Tavares, Márcia C. Neves, Tito Trindade and Mara G. Freire
2020, 58-93.
ISBN:
978-981-14-0510-5
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Aqueous biphasic systems formed by cholinium-based ionic liquids and mixtures of polymers

In Rasmus Fehrmann, Catherine Santini (Eds.), Ionic Liquids: Synthesis, Properties, Technologies and Applications
Teresa B.V Dinis, Catarina M.S.S. Neves, Luís Barbosa, João A.P. Coutinho, Mara G. Freire
2019, 29-54, Berlin, Walter de Gruyter GmbH.
ISBN:
978-3-11-058201-7
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Application of Ionic Liquids in Separation and Fractionation Processes

In Buxing Han and Tianbin Wu (Eds.), Green Chemistry and Chemical Engineering
Emanuel V. Capela, João A.P. Coutinho, Mara G. Freire
2019, 637-665, New York, NY, Springer.
ISBN:
978-1-4939-9059-7
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Immobilization of Ionic Liquids, Types of Materials, and Applications

In Zhang S. (Eds.), Encyclopedia of Ionic Liquids
Augusto Q. Pedro, João A. P. Coutinho, Mara G. Freire
2019, Springer.
ISBN:
978-981-10-6739-6
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Ionic Liquids and Deep Eutectic Solvents in the Field of Environmental Monitoring

In Płotka-Wasylka, Justyna, Namieśnik, Jacek (Eds.), Green Analytical Chemistry: Past, Present and Perspectives
Cardoso I.S., Pedro A.Q., Silvestre A.J.D., Freire M.G.
2019, 203-240, Singapore, Springer.
ISBN:
978-981-13-9104-0
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Use of Nanomaterials in the Pretreatment of Water Samples for Environmental Analysis

In Bhat AH, Jawaid M, O Sulliman FE, Al-Kindy SM (Eds.), Nanomaterials for Healthcare, Energy and Environment
Bernardo S, Sousa ACA, Neves MC, Freire MG
2019, 103-142, Aveiro, Springer Nature.
ISBN:
978-981-13-9832-2
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Application of Ionic Liquids in Separation and Fractionation Processes

In Robert A. Meyers (Eds.), Encyclopedia of Sustainability Science and Technology
Emanuel V. Capela, João A.P. Coutinho, Mara G. Freire
2018, 1-29, New York, USA, Springer.
ISBN:
978-1-4939-2493-6
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Ionic Liquids in Bioseparation Processes

In Toshiyuki ItohYoon-Mo Koo (Eds.), Advances in biochemical engineering/biotechnology
Belchior D.C.V., Duarte I.F., Freire M.G.
2018, 1-29, Springer, Berlin.
ISBN:
978-3-030-23080-7
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Monoclonal Antibodies – Addressing the Challenges on the Manufacturing Processing of an Advanced Class of Therapeutic Agents

In Atta-ur-Rahman (Eds.), Frontiers in Clinical Drug Research-Anti Infectives
Emanuel V. Capela, M. Raquel Aires-Barros, Mara G. Freire, Ana M. Azevedo
2017, 142-203, Sharjah, UAE, Bentham Science.
ISBN:
978-1-68108-488-6
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Imunoglobulina Y (IgY): uma Alternativa Promissora aos Anticorpos de Mamíferos

In Manuel A. Coimbra (Eds.), Bioquímica e Bem-Estar
M. V. Quental, M. R. Almeida, J. Gomes, J. Resende,P. Domingues, M. G. Freire
2017, Lisboa, Edições Afrontamento.
ISBN:
978-972-36-1560-9
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Aplicação de Sistemas Aquosos Bifásicos na Purificação de Biomoléculas

In Á. S. Lima and C. C. Santana (Eds.), Processos de Extração e Purificação de Biomoléculas
Á. S. Lima, N. S. O. Placido, R. L. S. França, I. O. A. Reis, M. M. Pereira, M. G. Freire
2017, Brazil, EDUNIT - Editora Universitária Tiradentes.
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CHAPTER 8:Ionic Liquids as Efficient Tools for the Purification of Biomolecules and Bioproducts from Natural Sources

In Rafal Bogel-Lukasik (Eds.), Ionic Liquids in the Biorefinery Concept : Challenges and Perspectives
Matheus M. Pereira, João A. P. Coutinho and Mara G. Freire
2016, 227-257, Royal Society of Chemistry.
ISBN:
978-1-84973-976-4
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Introduction to Ionic-Liquid-Based Aqueous Biphasic Systems (ABS)

In Mara G. Freire (Eds.), Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications
Mara G. Freire
2016, 1-25, Springer Berlin Heidelberg.
ISBN:
978-3-662-52875-4
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Predicting the Thermodynamic Behavior of Water & Ionic Liquids Systems Using COSMO-RS

In Gaune-Escard M, Seddon K R (Eds.), Molten Salts and Ionic Liquids: Never the Twain?
Freire MG, Santos LMNBF, Marrucho IM, Coutinho JAP
2010, John Wiley & Sons, Inc..
ISBN:
978-0471773924
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Waste Valorisation Using Ionic Liquids

Francisca e Silva; Ana Sousa; Mara Freire; João Coutinho
2022, Royal Society of Chemistry.
ISBN:
978-1-83916-468-2
>
Ionic-Liquid-Based Aqueous Biphasic Systems: Fundamentals and Applications

Mara G. Freire
2016, 315, Berlin , Springer Berlin Heidelberg.
ISBN:
978-3-662-52875-4
>
Separation of dyes with reversible aqueous biphasic systems
Ana Maria da Conceição Ferreira
2013, supervised by Ana M. Fernandes and Mara G. Freire.
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Aeration and Extraction in Multiphase Biological Reactors
Mara Guadalupe Freire Martins Martins
2007, supervised by João Manuel da Costa Araújo Pereira Coutinho; Isabel Marrucho.
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