Ana Luísa Daniel da Silva

Ana Luísa Daniel-da-Silva graduated in Chemical Engineering (2000) by Instituto Superior Técnico (Lisbon, Portugal) in 2000 and got her PhD degree in Materials Science, cum laude, from University of Alicante (Spain) in 2005. Since June 2009 she is Researcher at CICECO-Aveiro Institute of Materials and Chemistry Department of the University of Aveiro (UA). Her main scientific interests concern the development of nanostructured materials including functional nanoparticles and nanocomposites for applications in nanomedicine, bionanotechnology and water remediation. In particular, she is interested in novel strategies for surface modification with biopolymers and synthetic routes for preparing nanomaterials with innovative and enhanced properties, aiming the development of green nanosorbents and biocompatible nanomaterials. She has authored or co-authored 3 patent applications, 7 book chapters and more than 60 papers in international peer reviewed journals. In addition she has co-edited the book ‘Nanocomposite Particles for Bio-applicationsMaterials and Bio-interfaces’ (Pan Stanford, 2011). She has completed the supervision of 17 MSc theses and 17 graduation projects. At the present she (co-)supervises the scientific work of 3 Post-Doc fellows, 3 PhD students, 1 MSc student and 3 MSc researchers hired in the scope of the projects that are in progress. She has been strongly involved to several teaching activities namely by lecturing topics for post-graduation students within the subjects Nanochemistry and Frontiers of Inorganic Chemistry. As part of her academic activities she has been involved in communicating chemistry for non-specialized audiences, in particular issues related to Nanotechnology and Nanomaterials.

Academic Qualifications

 - PhD degree in Materials Science, University of Alicante (Spain), June 2005

   Thesis title: “Synthesis, characterization and adhesive properties of isocyanate ended quasi-prepolymers based adhesives”

 - BSc degree in Chemical Engineering (5 year program), IST, Lisbon (Portugal), April 2000

   Final Project title: “Production of Lignosulphonates using the residual liquor obtained in the wood pulp production (sulphite process)”

Scientific and professional activities

 -Present time: Assistant Researcher, Chemistry Department and CICECO, University of Aveiro

 -2005-2009: Postdoctoral fellow at CICECO, University of Aveiro

 -February-July 2000: Analyst at the company F. LIMA SA (Lisbon)

KEYWORDS: Functional nanomaterials; Nanocomposites; Colloidal Nanoparticles; Surface Modification; Environmental Nanotechnology; Biomaterials

1. ENGINEERED SURFACE FUNCTIONALIZATION OF NANOPARTICLES FOR BIOAPPLICATIONS AND WATER TREATMENT

 FOR WATER TREATMENT - Novel strategies for rational surface modification of magnetic nanoparticles with polymers extracted from renewable sources. The final aim is the development of low-cost high performance green nanosorbents for the uptake of emerging organic pollutants from water. Study of interface phenomena. Understanding sorption mechanisms.

Key Contributions:

S. F. Soares, T. Fernandes, M. Sacramento, T. Trindade, A. L. Daniel-da-Silva, Magnetic quaternary chitosan hybrid nanoparticles for the efficient uptake of diclofenac from water, Carbohydrate Polymers 2019, 203, 35-44

T. Fernandes, S. F. Soares, T. Trindade, A. L. Daniel-da-Silva, Magnetic Hybrid Nanosorbents for the Uptake of Paraquat from Water, Nanomaterials 2017, 7, 68

S. F. Soares, T. R. Simões, M. António, T. Trindade, A. L. Daniel-da-Silva, Hybrid Nanoadsorbents for the magnetically assisted removal of metoprolol from water, Chemical Engineering Journal 2016, 302, 560-569

S. F. Soares; T. Fernandes; T. Trindade; A. L. Daniel-da-Silva, Surface engineered magnetic biosorbents for water treatment, In. Green Adsorbents for Pollutant Removal. Environmental Chemistry for a Sustainable World, vol 18, 301-342, Springer 2018

FOR BIOAPPLICATIONS - Novel chemical strategies for the surface functionalization of inorganic nanocrystals (magnetic, plasmonic) for targeting/detecting biomolecules (e.g. proteins, biomarkers) that are in trace amounts in biofluids.

Key Contributions:

M. António, J. Nogueira, R. Vitorino, A. L. Daniel-da-Silva, Functionalized Gold Nanoparticles for the Detection of C-Reactive Protein, Nanomaterials 2018, 8, 200

C. Couto, R. Vitorino, A. L. Daniel-da-Silva, Gold nanoparticles and bioconjugation: a pathway for proteomic applications, Critical Reviews in Biotechnology 2017, 37, 238-250

R. Oliveira-Silva, J. P. Costa, R. Vitorino, A. L. Daniel-da-Silva, Magnetic chelating nanoprobes for enrichment and selective recovery of metalloproteases from human saliva, Journal Materials Chemistry B 2015, 3, 238-249

J. P. Costa, R. Oliveira-Silva, A. L. Daniel-da-Silva, R. Vitorino, Bionanoconjugation for proteomics applications – an overview, Biotechnology Advances 2014, 32(5), 952-970

2. POLYMER-BASED FUNCTIONAL NANOCOMPOSITES

Functional bionanocomposites merge the intrinsic functionalities of inorganic nanofillers and the biointerfaces of biopolymers. These are materials with unique responsive features of interest for biomedical, food and environmental applications. The properties of the bionanocomposites depend on the chemical nature of the organic and inorganic components but also depend on the interaction and synergy of these components, which are keys aspects investigated in this research line.

Key Contributions:

- S. Fateixa, R. S. Carvalho, A. L. Daniel-da-Silva, H. I. S. Nogueira, T. Trindade, Luminescent Carrageenan Hydrogels Containing Lanthanopolyoxometalates, European Journal of Inorganic Chemistry 2017, 43, 4976-4981.

- S. F. Soares, T. Trindade, A. L. Daniel-da-Silva, Carrageenan-Silica Hybrid Nanoparticles Prepared by a Non-Emulsion Method, European Journal of Inorganic Chemistry 2015, 27, 4588-4594.

- A. C. Estrada, A. L. Daniel-da-Silva, T. Trindade, Photothermally enhanced drug release by k-carrageenan hydrogels reinforced with multiwalled carbon nanotubes, RSC Advances 2013, 3, 10828-10836.

- A .M. Salgueiro, A. L. Daniel-da-Silva, S. Fateixa,T. Trindade, k-carrageenan hydrogel nanocomposites with release behavior mediated by morphological distinct Au nanofiller, Carbohydrate Polymers 2013, 91, 100-109.

- A. L. Daniel-da-Silva, J. Moreira, R. Neto, A. C. Estrada, A. M. Gil, T. Trindade, Impact of magnetic nanofillers in the swelling and release properties of k-carrageenan hydrogel nanocomposites, Carbohydrate Polymers 2012, 87, 328-335.

Ongoing projects

HOTSPOT- Novel upconversion nanoparticles for multimodal therapy of melanoma: pHOtothermal Therapy, PhOtodynamic therapy and chemotherapy. 2018-2021. (Team membre)

IF/00405/2014/CP1222/ CT0007- Stimuli-responsive bionanocomposites: towards remotely controlled nanomaterials. 2015-2020. Coordinator

SGH-Smart Green Homes; 2016-2019 (Team member)

PROTEUS - Produtos e Tecnologias para o sector do Eucalyptus Globulus; 2016-2019 (Team member)

Past projects

PTDC/MAR-BIO/3533/2012 - Remediação de águas salinas sob a influência de multicontaminantes (poluentes inorgânicos e emergentes), através da aplicação de nanopartículas magnéticas e resíduos biológicos: avaliação do risco ecológico e humano. 2013-2015; (Team member)

EXPL/BBB-BEP/0317/2012 - Desenvolvimento de uma plataforma em nanoescala para o enriquecimento de proteases. 2013-2014;  (Team member)

CERN/FP/123585/2011 - Perturbed Angular Correlations and Electron Channeling Experiments at ISOLDE - applied materials research with nuclear techniques, training and development. 2012 – 2014;(Team member)

PTDC/CTM-NAN/120668/2010 - Nanomaterials for the uptake of pollutant metal ions: efficiency. selectivity and recyclability. 2012-2015; (Team member)

PTDC/SAU-TOX/120953/2010 - Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials. 2012 -2014; (Team member)

CERN/FP/116320/2010 - Perturbed Angular Correlations and Electron Channeling Experiments at ISOLDE-applied materials research with nuclear techniques, training and development; 2011 – 2012; (Team member)

ERA-Eula/0003/2009 - Magnetotransduction: development of magnetic nanoparticle-viral vector complexes for therapeutic gene delivery in the senile brain. 2010 – 2012;(Team member)

CERN/FP/109357/2009 - Research on Magnetic and Multiferroic Materials using Radioactive Isotopes at ISOLDE-CERN. 2010 – 2011; (Team member)

NANO/NMed-SD/0140/200 - Integrated Lab On Chip Platforms for Medical Diagnostics. 2009 – 2011; (Team member)

PTDC/QUI/67712/2006 - Nanochemistry of magnetic/luminescent composites for in vitro medical diagnosis applications. 2008 – 2010; (Team member)

PTDC/SAU-BEB/66896/2006 - Implantable scaffolds for local osteo-sarcoma chemotherapy. 2007 – 2010;(Team member)

PhD Theses

-Maria de Almeida Vasconcelos António; SFRH/BD/136881/2018; Supervisor: AL Daniel-da-Silva; Co-supervisor: Rui Vitorino (ibimed). (2018-ongoing)

-João Tiago Moniz Fernandes; SFRH/BD/130934/2017; Supervisor: Tito Trindade; Co-supervisor: AL Daniel-da-Silva. (2017-ongoing)

-Sofia Farias Soares; SFRH/BD/121366/2016; Supervisor: AL Daniel-da-Silva; Co-supervisor: Tito Trindade. (2017-ongoing)

MSc Theses

18. Diogo Lopes, Multifunctional photocatalysts composites based on titania, Supervisors: Andrei Kavaleuski and A.L. Daniel-da-Silva (ongoing).

17. Adriana Bernardes, Liquid-phase exfoliation of highly oriented pyrolytic graphite and its oxidation by air-ozone atomization, Supervisors: Bruno Neves (Graphenest) and A.L. Daniel-da-Silva (2018).

16. Cátia Leal, Removal of AOX from paper pulp effluents using photocatalysis, Supervisors: A.L. Daniel-da-Silva and Paula Pinto (RAIZ) (2018).

15. Maria António, Detection of C-reactive protein in biological samples using functionalized gold nanoparticles, Supervisors: A.L. Daniel-da-Silva and Rui Vitorino (2017).

14. Joana Maia, Nanostructured additives for concrete, Supervisors: Frederico Maia and Cláudia Rocha (Smallmatek) and A.L. Daniel-da-Silva (2017).

13. Tiago Polónio, Treatment of the effluents of Kraft pulp industry using photocatalytic oxidation, Supervisors: António Mendes de Sousa (RAIZ) and A.L. Daniel-da-Silva (2016).

12. Tânia Silva, Study of alternative resins in decorative paints, Supervisors: Vasco Lopes (CIN) and A.L. Daniel-da-Silva (2015).

11. Ana Raquel Fernandes, Laccase immobilization onto magnetic nanoparticles: study and applications, Supervisors: A. Xavier and A.L. Daniel-da-Silva (2015).

10. Tânia Simões, Magnetic removal of pollutants from water using green nanocomposites, Supervisors: A.L. Daniel-da-Silva and T. Trindade (2015).

9. Marta Julia Busse, Bionanocomposites of Fe₃O₄/SiO₂ and alginate for the magnetic removal of Cr(III) species in water, Supervisors: T. Trindade and A.L. Daniel-da-Silva (2014).

8. Catarina Rebelo, Gold nanocomposites for controlled drug release, Supervisor: A.L. Daniel-da-Silva (2014).

7. Bianca Creaney, Nano-adsorventes para remoção magnética de corantes orgânicos de águas, Supervisors: A.L. Daniel-da-Silva (2013).

6. Maria Graça Oliveira, Hidrogéis nanocompósitos de ouro para aplicações em libertação controlada de fármacos, Supervisors: A.L. Daniel-da-Silva (2012).

5. Luís Melo, Libertação de prata ionica em nanocompositos, Supervisors: Tito Trindade and A.L. Daniel-da-Silva (2012).

4. Rui Pedro Silva, Funcionalização de nanopartículas magnéticas para o desenvolvimento de um sistema de caraterização de proteases, Supervisors: Rui Vitorino and A.L. Daniel-da-Silva (2012).

3. Ana Margarida Salgueiro, Hidrogeis termosensiveis compósitos contendo nanobastonetes de ouro, Supervisors: A. L. Daniel-da-Silva and Tito Trindade (2011).

2. Cristina Schitco, Thermo conductivity and electrical properties of PVDF/Cu nanocomposites, Supervisors: Paula Vilarinho and A.L. Daniel-da-Silva (2011).

1. Joana da Silva Moreira, Estudo de síntese e cinética de libertação em bionanocompósitos, Supervisors: Tito Trindade and  A.L. Daniel-da-Silva (2010).

Books 

T. Trindade; A. L. Daniel-da-Silva (Eds), Nanocomposite particles for bio-applications – materials and biointerfaces, Pan Stanford Publishing, 2011, ISBN: 978-981-4267-78-6

Book Chapters

 7. S. F. Soares; T. Fernandes; T. Trindade; A. L. Daniel-da-Silva, Surface engineered magnetic biosorbents for water treatment, In. Green Adsorbents for Pollutant Removal. Environmental Chemistry for a Sustainable World, vol 18, 301-342, Edited by Grégorio Crini and Eric Lichftouse, Published by Springer Nature, Cham, 2018. ISBN: 978-3-319-92110-5; DOI:10.1007/978-3-319-92111-2_9

6. P. L. Lopes, N. B. Barroca, A. L. Daniel-da-Silva, B. J. Leite Ferreira, Application of chitosan based materials for drug delivery, In. Frontiers in Biomaterials - Chitosan Based Materials and its Applications Volume 3, Chapter 8, 181-248, Edited by Guilherme Luiz Dotto, Sergio Paulo Campana-Filho and Luiz Antonio de Almeida Pinto, Published by Bentham Science Publishers Ltd, 2017, ISBN 978-1-68108-486-2, eISBN 978-1-68108-485-5

5. F. L. Sousa, A. L. Daniel-da-Silva, N. J. O. Silva, T. Trindade, Bionanocomposites for the magnetic removal of water pollutants, In. Eco-friendly Polymer Nanocomposites: Chemistry and Applications, Chapt 9, Springer, 2015, Edited by Vijay Kumar Thakur, ISBN: 978-81-322-2473-0

4. M. Cova, R. Oliveira-Silva, J. A. Ferreira, R. Ferreira, F. Amado, A. L. Daniel-da-Silva, R. Vitorino, Glycoprotein Enrichment Method Using a Selective Magnetic Nano-Probe Platform (MNP) Functionalized With Lectins, In. Clinical Proteomics-Methods and Protocols, Series “Methods in Molecular Biology”, vol.1243, Chapter 5, 83-100. Edited by Antonia Vlahou and Manousos Makridakis. Published by Humana Press, New York 2015. ISBN 978-1-4939-1871-3; DOI 10.1007/978-1-4939-1872-0_5

3. A. L. Daniel-da-Silva, T. Trindade, Biofunctional composites of polysaccharides containing inorganic nanoparticles, In. Nanocomposites, Intech – Open Access Publisher, 2011. ISBN: 978-953-308-55-0

2. A. S. Pereira, A. L. Daniel-da-Silva, T. Trindade, From nanoparticles to nanocomposites: an Overview
In. Nanocomposite particles for bio-applications– materials and biointerfaces, Chapt. 1. Pan Stanford Publishing, 2011. ISBN: 978-981-4267-78-6

1. A. L. Daniel-da-Silva, N. J. O. Silva, T. Trindade, A. M. Gil, Biocomposites containing magnetic nanoparticles, In. Nanocomposite particles for bio-applications– materials and biointerfaces, Chapt. 8, Pan Stanford Publishing, 2011, ISBN: 978-981-4267-78-6

Patents

2. Patente de Invenção Nacional nº 108283, 13-03-2015 (Portuguese Patent)
Ana Luísa Daniel da Silva; Tito Trindade; Sofia F. Soares
Partículas híbridas de biopolimero-silica e método para a sua produção (Biopolymer-silica hybrid particles and Method for their production)

1. Patente de Invenção Nacional nº 104136, 22-01-2010  (Portuguese Patent)
Mª Helena Fernandes, Paula Mª Vilarinho, Ana Luísa Silva, Natália Barroca
Método de preparação de suportes porosos compósitos de base polimérica para aplicação em engenharia de tecidos

 SCI Papers

67. S. F. Soares, T. Fernandes; M. Sacramento, T. Trindade, A. L. Daniel-da-Silva
Magnetic quaternary chitosan hybrid nanoparticles for the efficient uptake of diclofenac from water
Carbohydrate Polymers 2019, 203, 35-44
DOI: 10.1016/j.carbpol.2018.09.030

66. J. Nogueira, M. António, S. M. Mikhalev , S. Fateixa, T. Trindade, A. L. Daniel-da-Silva
Porous Carrageenan-Derived Carbons for Efficient Ciprofloxacin Removal from Water
Nanomaterials 2018, 8, 1004
DOI:10.3390/nano8121004

65. S. R. D. Gamelas, A. T. P. C. Gomes, N. M. M. Moura, M. A. F. Faustino, J. A. S. Cavaleiro, C. Lodeiro, M. I. S. Veríssimo, T. Fernandes, A. L. Daniel-da-Silva, M. T. S. R. Gomes, M. G. P. M. S. Neves
N-Confused Porphyrin Immobilized on Solid Supports: Synthesis and Metal Ions Sensing Efficacy
Molecules 2018, 23(4), 867
DOI:10.3390/molecules23040867

64. M. António, J. Nogueira, R. Vitorino, A. L. Daniel-da-Silva
Functionalized Gold Nanoparticles for the Detection of C-Reactive Protein
Nanomaterials 2018, 8, 200 (REVIEW)
DOI:10.3390/nano8040200

63. P. Pinheiro, A. L. Daniel-da-Silva, H. Nogueira, T. Trindade
Functionalized inorganic nanoparticles for magnetic separation and SERS detection of water pollutants
European Journal of Inorganic Chemistry 2018, 3443-3461
DOI:10.1002/ejic.201800132

62. R. Azevedo, J. Soares, C. Gaiteiro, A. Peixoto, L. Lima, D. Ferreira, M. Relvas-Santos, E. Fernandes, A. Tavares, S. Cotton, A. L. Daniel-da-Silva, L. Lara Santos, R. Vitorino, F. Amado, J. A. Ferreira
Glycan affinity magnetic nanoplatforms for urinary glycobiomarkers discovery in bladder cancer
Talanta 2018, 184, 347-355
DOI:10.1016/j.talanta.2018.03.028

61. S. F. Soares, M. I. Rodrigues, T. Trindade, A. L. Daniel-da-Silva
Chitosan-silica hybrid nanosorbents for oil removal from water
Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2017, 532, 305-313
DOI:10.1016/j.colsurfa.2017.04.076

60. S. Fateixa, R. S. Carvalho, A. L. Daniel-da-Silva, H. I. S. Nogueira, T. Trindade
Luminescent Carrageenan Hydrogels Containing Lanthanopolyoxometalates.
European Journal of Inorganic Chemistry 2017, 43, 4976-4981
DOI: 10.1002/ejic.201700888

59. F. Trindade, P. Bastos, A. Leite-Moreira, B. Manadas, R. Ferreira, S. F. Soares, A. L. Daniel-da-Silva, I. Falcao-Pires, R. Vitorino
A fractionation approach applying chelating magnetic nanoparticles to characterize pericardial fluid's proteome
Archives of Biochemistry and Biophysics 2017, 634, 1-10
DOI:10.1016/j.abb.2017.09.016

58. F. Trindade, P. Bastos, R. Ferreira, A. Leite-Moreira, I. Falcão-Pires, B. Manadas, A. L. Daniel-da-Silva, R. Vitorino
EDTA-functionalized Magnetic Nanoparticles: a suitable platform for the analysis of low abundant urinary proteins
Talanta 2017,170, 81-88
DOI:10.1016/j.talanta.2017.03.087

57. C.C. Fortes, A. L. Daniel-da-Silva, A. M. R. B. Xavier, A. P. Tavares
Optimization of enzyme immobilization on functionalized magnetic nanoparticles for laccase biocatalytic reactions
Chemical Engineering & Processing: Process Intensification 2017, 117, 1-8
DOI:10.1016/j.cep.2017.03.009

56. T. Fernandes, S. F. Soares, T. Trindade, A. L. Daniel-da-Silva
Magnetic Hybrid Nanosorbents for the Uptake of Paraquat from Water
Nanomaterials 2017, 7, 68
DOI: 10.3390/nano7030068

55. V. Bastos, J. M. P. Ferreira de Oliveira, J. Carrola, A. L. Daniel-da-Silva, I. F. Duarte, C. Santos, H. Oliveira
Coating independent cytotoxicity of citrate- and PEG-coated silver nanoparticles on a human hepatoma cell line
Journal of Environmental Sciences 2017, 51, 191-201
DOI:10.1016/j.jes.2016.05.028

54. A. R. Fernandes, A. P. Tavares, A. L. Daniel-da-Silva, A. M. R. B. Xavier
EDTA-Cu(II) chelating magnetic nanoparticles as a support for laccase immobilization
Chemical Engineering Science 2017, 158, 599-605
DOI:10.1016/j.ces.2016.11.011

53. C. Couto, R. Vitorino, A. L. Daniel-da-Silva
Gold nanoparticles and bioconjugation: a pathway for proteomic applications
Critical Reviews in Biotechnology 2017, 37, 238-250 (REVIEW)
DOI:10.3109/07388551.2016.1141392

52. S. F. Soares, T. R. Simões, T. Trindade, A. L. Daniel-da-Silva
Highly Efficient Removal of Dye from Water Using Magnetic Carrageenan/Silica Hybrid Nano-adsorbents
Water, Air and Soil Pollution 2017, 228, 87
DOI: 10.1007/s11270-017-3281-0

51. D. S. Tavares, C. B. Lopes, A. L. Daniel-da-Silva, C. Vale, T. Trindade, M. E. Pereira
Mercury in river, estuarine and seawaters - Is it possible to decrease realist environmental concentrations in order to achieve environmental quality standards?
Water Research 2016, 106, 439-449
DOI:10.1016/j.watres.2016.10.031

50. V. Bastos, D. Brown, H. Johnston, A. L. Daniel-da-Silva, I. F. Duarte, C. Santos, H. Oliveira
Inflammatory responses of a human keratinocyte cell line to 10 nm citrate- and PEG-coated silver nanoparticles
Journal of Nanoparticle Research 2016, 18(7), article 205
DOI:10.1007/s11051-016-3515-x

49. S. F. Soares, T. R. Simões, M. António, T. Trindade, A. L. Daniel-da-Silva
Hybrid Nadoadsorbents for the magnetically assisted removal of metoprolol from water
Chemical Engineering Journal 2016, 302, 560-569
DOI:10.1016/j.cej.2016.05.079

48. C. Couto, B. Neves, R. Ferreira, A. L. Daniel-da-Silva, R. Vitorino
Proteomic studies with a novel nano-magnetic chelating system to capture metalloproteins and its application in the preliminary study of monocyte and macrophage sub-secretome
Talanta 2016, 158, 110-117
DOI:10.1016/j.talanta.2016.05.051

47. V. Bastos, J. M. P. Ferreira de Oliveira, D. Brown, H. Jonhston, E. Malheiro, A. L. Daniel-da-Silva, I. F. Duarte, C. Santos, H. Oliveira
The influence of Citrate or PEG coating on silver nanoparticle toxicity to a human keratinocyte cell line
Toxicology Letters 2016, 249, 29-41
DOI:10.1016/j.toxlet.2016.03.005

46. J. Carrola, V. Bastos, I. Jarak, R. Oliveira-Silva, E. Malheiro, A. L. Daniel-da-Silva, H.Oliveira, C. Santos, A. M. Gil, I. F. Duarte
Metabolomics of silver nanoparticles toxicity in HaCaT cells: structure–activity relationships and role of ionic silver and oxidative stress
Nanotoxicology 2016, 10(8), 1105-1117
DOI:10.1080/17435390.2016.1177744

45. R. S. Carvalho, A. L. Daniel-da-Silva, T. Trindade
Uptake of Europium(III) from water using magnetite nanoparticles
Particle and Particle Systems Characterization 2016, 33, 150-157
DOI: 10.1002/ppsc.201500170

44. S. F. Soares, T. Trindade, A. L. Daniel-da-Silva
Carrageenan-Silica Hybrid Nanoparticles Prepared by a Non-Emulsion Method
European Journal of Inorganic Chemistry 2015, 27, 4588-4594
DOI:10.1002/ejic.201500450

43. A. L. Daniel-da-Silva, A. M. Salgueiro, B. Creaney, R. Oliveira-Silva, N. J. O. Silva, T. Trindade
Carrageenan-grafted magnetite nanoparticles as recyclable sorbents for dye removal
Journal of Nanoparticle Research 2015, 17, Article 302
DOI: 10.1007/s11051-015-3108-0

42. F. Trindade, F. Amado, R. P. Oliveira-Silva, A. L. Daniel-da-Silva, R. Ferreira, J. Klein, R. Faria-Almeida, P. S. Gomes, R. Vitorino
Towards the definition of a Peptidome Signature and Protease Profile in Chronic Periodontitis
Proteomics-Clinical Applications 2015, 9, 917-927
DOI: 10.1002/prca.201400191

41. S. Fateixa, S. F. Soares, A. L. Daniel-da-Silva, H. I. S. Nogueira, T. Trindade
Silver-gelatine bionanocomposites for qualitative detection of a pesticide by SERS
Analyst 2015, 140, 1693-1701
DOI:10.1039/C4AN02105C

40. R. Oliveira-Silva, J. P. Costa, R. Vitorino, A. L. Daniel-da-Silva
Magnetic chelating nanoprobes for enrichment and selective recovery of metalloproteases from human saliva
Journal Materials Chemistry B 2015, 3, 238-249
DOI:10.1039/C4TB01189A

39. F. M. Silva, R. J. B. Pinto, A. L. Daniel-da-Silva, T. Trindade
Cationic release behaviour of antimicrobial cellulose/silver nanocomposites
Cellulose 2014, 21(5), 3551-3560
DOI:10.1007/s10570-014-0378-0

38. D.S. Tavares, C.B. Lopes, A.L. Daniel-da-Silva, A.C. Duarte, T. Trindade, E. Pereira
The role of operational parameters on the uptake of mercury by dithiocarbamate functionalized particles
Chemical Engineering Journal 2014, 254, 559-570
DOI:10.1016/j.cej.2014.06.008

37. J. P. Costa, R. Oliveira-Silva, A. L. Daniel-da-Silva, R. Vitorino
Bionanoconjugation for proteomics applications – an overview
Biotechnology Advances 2014, 32(5), 952-970
DOI:10.1016/j.biotechadv.2014.04.013

36. S. Fateixa, A. L. Daniel-da-Silva, H. I. S. Nogueira, T. Trindade
Raman signal enhancement dependence on the gel strength of Ag/hydrogels used as SERS substrates
The Journal of Physical Chemistry C 2014, 118(19), 10394-10392
DOI:10.1021/jp500301q

35. M. Q. Mesquita, J. C. J. M. D. S. Menezes, S. M. G. Pires, M. G. P. M. S. Neves, M. M. Q. Simões, A. C. Tomé, J. A. S. Cavaleiro, Â. Cunha, A. L. Daniel-da-Silva, A. Almeida, M. A. F. Faustino
Pyrrolidine fused chlorin photosensitizer immobilized on solid supports for the photoinactivation of Gram negative bacteria
Dyes and Pigments 2014, 110, 123-133
DOI:10.1016/j.dyepig.2014.04.025

34. P. C. Pinheiro, D. S. Tavares, A. L. Daniel-da-Silva, C. B. Lopes, E. Pereira, J. P. Araujo, C.T. Sousa, T. Trindade
Ferromagnetic sorbents based on nickel nanowires for efficient uptake of mercury from water
ACS Applied Materials & Interfaces 2014, 6(11), 8274-8280
DOI:10.1021/am5010865

33. B. J. M. Leite Ferreira, N. B. Barroca, P. P. Lopes, A. L. Daniel-da-Silva, M. H. V. Fernandes, R. N. Correia
Properties of novel PMMA-co-EHA bone cements filled with hydroxyapatite
Polymer Composites 2014, 35(4), 759-767
DOI:10.1002/pc.22719

32. P. C. Pinheiro, A. L. Daniel-da-Silva, D. S. Tavares, M. P. Calatayud, G. F. Goya, T. Trindade
Fluorescent Magnetic Bioprobes by Surface Modification of Magnetite Nanoparticles
Materials 2013, 6, 3213-3225
DOI:10.3390/ma6083213

31. A. M. Salgueiro, A. L. Daniel-da-Silva, A. V. Girao, P. C. Pinheiro, T. Trindade
Unusual dye adsorption behavior of k-carrageenan coated superparamagnetic nanoparticles
Chemical Engineering Journal 2013, 229, 276-284
DOI:10.1016/j.cej.2013.06.015

30. S. Fateixa, A. L. Daniel-da-Silva, N. Jordão, A. Barros-Timmons, T. Trindade,
Effect of colloidal silver and gold nanoparticles on the thermal behavior of poly(t-butyl acrylate) composites
Colloids and Surfaces A, Physicochemical and Engineering Aspects 2013, 436, 231-236
DOI:10.1016/j.colsurfa.2013.06.009

29. C. B. Lopes , P. Figueira, D. S. Tavares, Z. Lin, A. L. Daniel-da-Silva, A. C. Duarte, J. Rocha, T. Trindade, E. Pereira
Core-shell magnetite-silica dithiocarbamate-derivatised particles achieve the Water Framework Directive quality criteria for mercury in surface waters
Environmental Science and Pollution Research 2013, 20, 5963-5974
DOI:10.1007/s11356-013-1615-z

28. A. C. Estrada, A. L. Daniel-da-Silva, T. Trindade
Photothermally enhanced drug release by k-carrageenan hydrogels reinforced with multiwalled carbon nanotubes
RSC Advances 2013, 3, 10828-10836
DOI:10.1039/C3RA40662H

27. D. S. Tavares, A. L. Daniel-da-Silva, C. B. Lopes, N. J. O. Silva, V. S. Amaral, J. Rocha, E. Pereira, T. Trindade
Efficient sorbents based on magnetite coated with siliceous hybrid shells for removal of mercury ions
Journal Materials Chemistry A 2013, 1, 8134-8143
DOI: 10.1039/C3TA10914C

26. A. L. Daniel-da-Silva, R. S. Carvalho, T. Trindade
Magnetic Hydrogel Nanocomposites and Composite Nanoparticles – a Review of Recent Patented Works
Recent Patents on Nanotechnology 2013, 7, 153 – 166
DOI:10.2174/18722105113079990008

25. A .M. Salgueiro, A. L. Daniel-da-Silva, S. Fateixa,T. Trindade
k-carrageenan hydrogel nanocomposites with release behavior mediated by morphological distinct Au nanofiller
Carbohydrate Polymers 2013, 91, 100-109
DOI:10.1016/j.carbpol.2012.08.004

24. J. F. B. Barata, A. L. Daniel-da-Silva, M. G. P. M .S. Neves, J. A. S. Cavaleiro, T. Trindade
Corrole-silica hybrid particles: synthesis and effects on singlet oxygen generation
RSC Advances 2013, 3, 274-280
DOI: 10.1039/C2RA22133K

23. A. L. Daniel-da-Silva, A. M. Salgueiro, T. Trindade
Effects of Au nanoparticles on thermoresponsive genipin-crosslinked gelatin hydrogels
Gold Bulletin 2013, 46, 25-33
DOI:10.1007/s13404-012-0078-1

22. N. B. Barroca, A. L. Daniel-da-Silva, P. S.Gomes, M.H.R. Fernandes, S. Lanceros-Mendez, P. Sharma, A. Gruverman, M.H.V. Fernandes, P. M. Vilarinho
Suitability of PLLA as piezoelectric substrates for tissue engineering evidenced by microscopy techniques
Microscopy and Microanalysis 2012, 18 (suppl 5), 63-64
DOI:10.1017/S1431927612012974

21. A. L. Daniel-da-Silva, J. Moreira, R. Neto, A. C. Estrada, A. M. Gil, T. Trindade
Impact of magnetic nanofillers in the swelling and release properties of k-carrageenan hydrogel nanocomposites
Carbohydrate Polymers 2012, 87, 328-335
DOI:10.1016/j.carbpol.2011.07.051

20. J.A. Ferreira, A.L. Daniel-da-Silva, R.M.P. Alves, D.S. Duarte, I. Vieira, R. Ferreira, L. Lara Santos, R. Vitorino, F. Amado
Synthesis and optimization of lectin functionalized nanoprobes for the selective recovery of glycoproteins from human body fluids
Analytical Chemistry 2011, 83, 7035-7043
DOI:10.1021/ac200916j

19. P. Figueira, C. B. Lopes, A. L. Daniel-da-Silva, E. Pereira, A. C. Duarte, T. Trindade
Removal of mercury (II) by dithiocarbamate surface functionalized magnetite particles: application to synthetic and natural spiked waters
Water Research 2011, 45, 5773-5784
DOI:10.1016/j.watres.2011.08.057

18. A. L. Daniel-da-Silva, L. Ferreira, A. M. Gil, T. Trindade
Synthesis and swelling behavior of temperature responsive k-carrageenan nanogels
Journal of Colloid and Interface Science 2011, 355, 512-517
DOI:10.1016/j.jcis.2010.12.071

17. N. Barroca, P. M. Vilarinho, A. L. Daniel-da-Silva, A. Wu, M.H.V. Fernandes, A. Gruverman
Protein Adsorption on Piezoelectric Poly (L-lactic) acid thin films by scanning probe microscopy
Applied Physics Letters 2011, 98, 133705
DOI:10.1063/1.3555444

16. K. B. Sidhpuria, A. L. Daniel-da-Silva, T. Trindade, J. A. P. Coutinho
Supported ionic liquid silica nanoparticles (SILnPs) as an efficient and recyclable heterogeneous catalyst for the dehydration of fructose to 5-hydroxymethylfurfural
Green Chemistry 2011, 13, 340-349
DOI: 10.1039/C0GC00690D

15. N. B. Barroca, A. L. Daniel-da-Silva, P. M. Vilarinho, M. H. V. Fernandes
Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass additions
Acta Biomaterialia 2010, 6, 3611-3620
DOI:10.1016/j.actbio.2010.03.032

14. P. I. Girginova, A. L. Daniel-da-Silva, C. Lopes, P. Figueira, M. Ortero, V. S. Amaral, E. Pereira, T. Trindade
Silica coated magnetite nanoparticles for magnetic removal of Hg2+ from water
Journal of Colloid and Interface Science 2010, 345(2), 234-240
DOI:10.1016/j.jcis.2010.01.087

13. A. L. Daniel-da-Silva, S. Fateixa, A. J. Guiomar, B. F. O. Costa, N. J. O. Silva, T. Trindade, B. J. Goodfellow, A. M. Gil
Biofunctionalized magnetic hydrogel nanospheres of magnetite and kappa-carrageenan
Nanotechnology 2009, 20, 355602, 1-10
DOI:10.1088/0957-4484/20/35/355602

12. N. B. Barroca, A. L. Daniel-da-Silva, M. H. V. Fernandes, P. M. Vilarinho
Porogen effect of bioactive glass on poly(L-lactide) scaffolds: evidences by electron microscopy
Microscopy and Microanalysis 2008, 14 (S3) 65-66
DOI:10.1017/S143192760808940X

11. A. L. Daniel-da-Silva, R. Lóio, J. A. Lopes-da-Silva, T. Trindade, B. J. Goodfellow, A. M. Gil
Effects of magnetite nanoparticles on the thermo-rheological properties of carrageenan hydrogels
Journal of Colloid and Interface Science 2008, 324 (1-2), 205-211
DOI:10.1016/j.jcis.2008.04.051

10. A.L. Daniel-da-Silva, A.M. Gil, R. N. Correia
Production of bioactive nano-hydroxyapatite/polysaccharide composites for bone tissue engineering
Materials Science Forum 2008, 587-588, 22-26
DOI:10.4028/www.scientific.net/MSF.587-588.22

9. A.L. Daniel-da-Silva, F. Pinto, J.A. Lopes-da-Silva, T. Trindade, B.J. Goodfellow, A.M. Gil
Rheological behaviour of thermoreversible k-carrageenan/nanosilica gels
Journal of Colloid and Interface Science 2008, 320, 575-581
DOI:10.1016/j.jcis.2008.01.035

8. A.L. Daniel-da-Silva, J.C. Bordado, J.M. Martín-Martínez
Moisture curing kinetics of isocyanate ended urethane quasi-prepolymers monitored by IR spectroscopy and DSC
Journal of Applied Polymer Science 2008, 107(2), 700-709
DOI:10.1002/app.26453

7. A.L.D. Silva, J.M. Martín-Martínez, J.C.M. Bordado
Influence of the storage of reactive urethane quasi-prepolymers in their composition and adhesion properties
International Journal of Adhesion and Adhesives 2008, 28, 29-37
DOI:10.1016/j.ijadhadh.2007.03.002

6. A.L. Daniel-da-Silva, J. C. Bordado, J.M. Martín-Martínez
Evidences of phase separation in moisture cured poly(urethane)ureas by means of temperature modulated differential scanning calorimetry
Journal of Polymer Science Part B: Polymer Physics 2007, 45(22), 3034-3045
DOI:10.1002/polb.21298

5. A.L. Daniel-da-Silva, T. Trindade, B.J. Goodfellow, B.F.O. Costa, R.N. Correia, A.M. Gil
In situ synthesis of magnetite nanoparticles in carrageenan gels
Biomacromolecules 2007, 8(8), 2350-2357
DOI: 10.1021/bm070096q

4. A.L. Daniel-da-Silva, A.B. Lopes, A.M. Gil, R.N. Correia
Synthesis and characterization of porous k-carrageenan/calcium phosphate nanocomposites scaffolds
Journal of Materials Science 2007, 42(20), 8581-8591
DOI:10.1007/s10853-007-1851-z

3. A.L. Daniel-da-Silva, J.C.M. Bordado, J.M. Martín-Martínez
Use of isoconversional methods to analyze the cure kinetics of isocyanate ended quasi-prepolymers with water
Journal of Applied Polymer Science 2007, 104(2), 1049-1057
DOI:10.1002/app.24914

2. A.L.D. da Silva, J.C.M. Bordado, J.M. Martín-Martínez
Influence of the free isocyanate content in the adhesive properties of reactive trifunctional polyether urethane quasi-prepolymers
International Journal of Adhesion and Adhesives 2006, 26(5), 355-362
DOI:10.1016/j.ijadhadh.2005.06.001

1. A. L. Silva, J.C. Bordado
Recent Developments in Polyurethane Catalysis: Catalytic Mechanisms Review
Catalysis Reviews. Science and Engineering 2004, 46-1, 31-51
DOI:10.1081/CR-120027049

Referee of SCI journals

ACS Applied Materials & Interfaces, ACS Applied Nano Materials, ACS Omega, Biomacromolecules, Biomaterials, Carbohydrate Polymers, Industrial & Engineering Chemistry Research, International Journal of Biological Macromolecules, Journal of Colloid and Interface Science, Journal of Physics and Chemistry of Solids, Nanotechnology, NPG Asia Materials, RSC Advances, Separation and Purification Technology, Water Science and Technology

Verified Peer Review Record at the Publons Platform:
https://publons.com/author/897314/ana-l-daniel-da-silva

Evaluation of projects/proposals

-European: Future and Emerging Technologies (FET-OPEN-RIA)

-National: ANI-Agência Nacional de Inovação

Editorial Activities

-Molecules–Member of Editorial Board (2018-)

-Nanomaterials–Guest Editor Special Issue “Green Nanotechnologies for Water Remediation Processes”(2018)

-Nanocomposite particles for bio-applications,Pan Stanford,2011 (book)