Carmen Sofia da Rocha Freire Barros

Principal Researcher

Short CV


Researcher ID :


Carmen Freire was born in 1976 in Venezuela. In 1994 she concluded high school at Escola Secundária José Estevão (Aveiro), and, motivated by an enormous interest in Chemistry, started her graduation in Industrial Chemistry at the University of Aveiro (UA).


After concluding her graduation in 1998, she started her PhD work, “Eucalyptus globulus Low Molecular Weight Organic Compounds: Behavior During Wood Kraft Pulping and Pulp Bleaching”, at the Chemistry Department of the University of Aveiro. In early 2003, she embraced a post-doctoral project on “Surface Chemical Modification of Cellulose Fibers for Novel Paper and Composite Materials”, developed jointly between the Department of Chemistry of UA and the EFPG (presently Pagora), Institut Polytechnique de Grenoble a forefront research group in the domain of Macromolecular Materials from Renewable Resources. During this period, she got a solid background and knowledge on the development and characterization of natural polymers-based materials.


Since 2006, as a Auxiliary Reseracher (from January 2006 to June 2011) and now as a Principal Researcher (FCT Researcher), she has leaded the research on materials and composites from cellulose and other polysaccharides within BioPol4Fun group at CICECO/UA .


Main achievements:


  • 164 articles in SCI journals (December 2018).
  • 3 National patents and 2 European patent.
  • More than 170 communications in International Conferences
  • Referee for several high impact factor international journals in the areas of biomacromolecules, polysaccharides, green and sustainable chemistry and materials in general
  • Concluded the supervision of 3 PhD, 3 Post-Docs, 31 Master theses,

Scientific Interests

Her research interests are centred on the Chemistry of polymers from renewable resources (caracterization and application) and development of new sustainable composite materials and  nanostructured materails  for disntinct appications


Present Research Group

BioPol4Fun- Innovation in biopolymeric functional materials and bioactive compounds

Supervisor or co-supervisor of 5 Pos-doctorate students, 10 PhD student and 4 Master students.

Main present collaborators


Armando Silvestre, Ana Barros-Timmons, Mara Freire, João Coutinho,Graça Neves, Paulo Claro, Iola Duarte  e Filipe Figueiredo (Department of Chemistry, University of Aveiro),

Adelaide Almeida, Helena Oliveira (Department of Biology, University of Aveiro)

Paula Alexandrina Marques (TEMA, University of Aveiro)

Isabel Marrucho (IST)

Fátima Duarte (CEBAL, Beja)

Catarina Rosado (Universidade Lusófona, Lisboa)

Isabel Almeida e Paulo Costa (Faculty of Pharmacy, University of Porto)

Fernando Dourado e Miguel Gama (University of Minho)


Stefan Spirk (TU Graz,  Austria)

Hélder Santos (University of Helsinki, Finland)

Pedro Fardim  (Abo Akademi, Finland and University of Leuven, Belgium)

Ana Alonsa Varona (UPV, San Sebastian)

Patrizia Sadocco (SSCCP, Stazione Sperimentale Carta, Cartoni e Paste per Carta, Italy)



Selected Publications


Nuno H.C.S. Silva, Carla Vilela, Adelaide Almeida, Isabel M. Marrucho, Carmen S.R.Freire, Pullulan-based nanocomposite films for functional food packaging: Exploiting lysozyme nanofibers as antibacterial and antioxidant reinforcing additives, Food Hydrocolloids, 2018, 77, 921-930.

Louise Saidi, Carla Vilela, Helena Oliveira, Armando J.D. Silvestre, Carmen S.R. Freire, “Poly(N-methacryloyl glycine)/nanocellulose composites: pH-sensitive systems for controlled release of diclofenac”, Carbohydr. Polym., 2017, 169, 357-365.

Carla Vilela, Ricardo J. B. Pinto, Joel Coelho, M. R. M. Domingues, Sara Daina, Patrizia Sadocco, Sónia A. O. Santos, Carmen S. R. Freire, Bioactive chitosan/ellagic acid films with UV-light protection for active food packaging, Food Hydrocolloids, 2017, 73, 120-128.        

Joana F.B. Barata, Ricardo J.B. Pinto, Vanda I.R.C. Vaz Serra, Armando J.D. Silvestre, Tito Trindade, Maria Graça P.M.S. Neves, José A.S. Cavaleiro, Sara Daina, Patrizia Sadocco, Carmen S.R. Freire, “Fluorescent bioactive corrole grafted-chitosan films”, Biomacromolecules, 2016, 17, 1395-1403.                                                                                                                      

Liliana C. Tomé, Ricardo J. B. Pinto, Eliane Trovatti, Carmen S. R. Freire, Armando J. D. Silvestre, Carlos Pascoal Neto, Alessandro Gandini, Transparent bionanocomposites with improved properties prepared from acetylated bacterial cellulose and poly(lactic acid) through a simple approach, Green Chem., 2011, 13, 419-427

Present projects

NanoBioinks- Engineering bio-based nanofibers for the development of high performance bioinks for 3D bioprinting”, CENTRO-01-0145-FEDER-031289, FCT/MCTES, (PI), 2018-                                                                                                                 
CORLUTNA- Systems based on corrolic macrocycles for luminescent thermometry  at nanoscale”, Projeto nº 031523 com o apoio financeiro da Fundação para a Ciência e Tecnologia/MCTES,  (co-PI) 2018-                                                                                             
“InPaCTus-  Products and Technologies from eucalipt”, RCI, I&DANI/AICEP, coordinated by Navigator Company, (PI of 3 sub-projects)

MultiBiorefinery – Estratégias multiuso para a valorização de uma gama alargada de subprodutos agroflorestais e das pescas: Um passo em frente na criação de uma biorrefinaria integrada” (POCI-01-0145-FEDER-016403), (team member)                                       
“AgroForWealth – Biorefinery of agro-forest residues: a strategy for the valorization of resources for wealth and sustainability“; CCDRC (team member) 

INNOVATE- Implantable organic Devices for advanced therapies”, University of Algarve, University of Aveiro, PTDC/EEI-AUT/5442/2014, (PI at UA)

DeepBiorefinery: "Natural Deep eutectic solvents: a platform to boost Eucalyptus globulus and Quercus suber cork integrated biorrefinery”, Universidade de Aveiro e ITQB. PTDC/AGR-TEC/1191/2014 (team member)

Ongoing Supervisions


Bacterial Cellulose Membranes for Proton Exchange Fuel Cells (EXPL/CTM-ENE/0548/2012)

PartnerFundação para a Ciência e a Tecnologia
Bacterial cellulose fuell cells proton exchange membranes in situ polymerization/grafting

BIOBLOCKS - Concepção de produtos de base biológica como percursores para a bioindústria de síntese química e de biomateriais a pertir de fontes renováveis lenhocelulósicas (BioBlocks)

Local CoordinatorIndustry National
O aumento dos preços de petróleo e uma maior apetência dos consumidores por produtos ecológicos e sustentáveis, têm vindo a viabilizar progressivamente o processo de produção e comercialização de biocombustíveis, bioquímicos e biopolímeros com base em materiais de fontes renováveis alternativos aos de origem petroquímica, permitindo a emergência...

Bioinspired nanostructured biocomposites based on proteins and polysaccharides nanofibrils (EXPL/CTM-POL/1802/2013)

CoordinatorFundação para a Ciência e a Tecnologia
Proteins and polysaccharides nanofibrils Nanostructured materials Self-assembly Biomedical applications

Controlled chemical modification of polysaccharides for the development of novel materials (PTDC/QUI/68472/2006 )

CoordinatorFundação para a Ciência e a Tecnologia
Polysaccharides Chemical modification Composites Functional materials

Corrole based systems for luminescent thermometry at nanoscale (CORLUTNA)

PartnerFundação para a Ciência e a Tecnologia
Temperature (T) is a fundamental parameter that affects the behavior of physical, chemical and biological systems in a wide variety of ways. Measuring T is important in many fields: photonic devices, nano/microelectronics, medical diagnostics, nanomedicine. Regarding the several classes of thermometers, one possible approach is to use dye lumine...

DeepBiorefinery - Natural Deep Eutectic Solvents: A platform to Boost Eucalyptus globulus and Quercus suber cork integrated Biorefinerie (DeepBiorefinery )

PartnerFundação para a Ciência e a Tecnologia
natural deep eutetic solvents, biorefinery, green separation processes

Development of new polyesters derived from 2,5-furandicarboxylic acid (PTDC/QUI-QUI/101058/2008)

PartnerFundação para a Ciência e a Tecnologia
2,5-furandicarboxylic acid Polyesters synthesis Materials from renewable sources Biorefinery

Engenharia de nanofibras de origem biológica para o desenvolvimento de biotintas nanoestruturadas de elevada performance para bio-impressão 3-D (NANOBIOINKS)

PartnerFundação para a Ciência e a Tecnologia

Eucalyptus triterpenic biological activity (PTDC/AGR-FOR/3187/2012)

Local CoordinatorFundação para a Ciência e a Tecnologia
Eucalyptus spp Ionic Liquids Antitumoral Activity Metabolomics

Green chemicals and technologies for the wood-to-textile value chain. (GRETE)

PartnerEuropean Comission
The GRETE project will tackle the challenges caused by increased global demand for sustainable textile fibres by offering new breakthroughs in the wood-to-textile value chain. The substitution of cotton by man-made cellulose fibres is also necessary because of sustainability issues. Currently the raw material base for the production of man-made ...

GREENPEC - Desenvolvimento de um plastificante primário para PVC, de origem animal e livre de ftalatos (GREENPEC )

PartnerIndustry National
O objetivo principal deste projeto, levado a cabo pelo consórcio entre a Sapec Química e a Universidade de Aveiro, consiste no desenvolvimento de um plastificante primário para PVC originado a partir de óleos vegetais, os quais são considerados recursos renováveis e agentes de crescimento sustentável. Com o cumprimento destes objetivos, prevê-se...

INNOVATE-Implantable Organic Devices for Advanced Therapies (INNOVATE)

Local CoordinatorFundação para a Ciência e a Tecnologia

Innovative Products and Technologies from Eucalyptus Project (InPacTus)

PartnerIndustry National
Inpactus, to be developed by the Consortium, aims to develop new solutions, such as cellulosic pulps with innovative features, new paper products with different specificities and functions, tissue paper with innovative properties, new bioproducts, biofuels and other materials obtained from the deconstruction and conversion of forest bio...

Metabolic profiling: a novel tool for evaluation of the toxicological and biological effects of nanomaterials (PTDC/SAU-TOX/120953/2010)

PartnerFundação para a Ciência e a Tecnologia
metabolic profiling and metabonomics silver nanoparticles toxicological and biological effects nanotoxicology


Enhanced Conversion of Xylan into Furfural using Acidic Deep Eutectic Solvents with Dual Solvent and Catalyst Behavior

Morais, ES; Freire, MG; Freire, CSR; Coutinho, JAP; Silvestre, AJD
2020, CHEMSUSCHEM, 13, 4, 784-790.
ISBN: 1864-564X

Extraction of High Value Triterpenic Acids from Eucalyptus globulus Biomass Using Hydrophobic Deep Eutectic Solvents

Silva, NHCS; Morais, ES; Freire, CSR; Freire, MG; Silvestre, AJD
2020, MOLECULES, 25, 1.
ISBN: 1420-3049

Multifunctional hybrid structures made of open-cell aluminum foam impregnated with cellulose/graphene nanocomposites

Pinto, SC; Silva, NHCS; Pinto, RJB; Freire, CSR; Duarte, I; Vicente, R; Vesenjak, M; Marques, PAAP
ISBN: 1879-1344

Resistive switching of silicon-silver thin film devices in flexible substrates

Dias, C; Leitao, DC; Freire, CSR; Gomes, HL; Cardoso, S; Ventura, J
2020, NANOTECHNOLOGY, 31, 13.
ISBN: 1361-6528

Flexible Nanocellulose/Lignosulfonates Ion-Conducting Separators for Polymer Electrolyte Fuel Cells

Vilela, C; Morais, JD; Silva, ACQ; Munoz-Gil, D; Figueiredo, FML; Silvestre, AJD; Freire, CSR
2020, NANOMATERIALS, 10, 9.
ISBN: 2079-4991

Swellable Gelatin Methacryloyl Microneedles for Extraction of Interstitial Skin Fluid toward Minimally Invasive Monitoring of Urea

Fonseca, DFS; Costa, PC; Almeida, IF; Dias-Pereira, P; Correia-Sa, I; Bastos, V; Oliveira, H; Vilela, C; Silvestre, AJD; Freire, CSR
ISBN: 1616-5195

Highly Electroconductive Nanopapers Based on Nanocellulose and Copper Nanowires: A New Generation of Flexible and Sustainable Electrical Materials

Pinto, RJB; Martins, MA; Lucas, JMF; Vilela, C; Sales, AJM; Costa, LC; Marques, PAAP; Freire, CSR
2020, ACS APPLIED MATERIALS & INTERFACES, 12, 30, 34208-34216.
ISBN: 1944-8252

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Pedro, SN; Freire, CSR; Silvestre, AJD; Freire, MG
ISBN: 1422-0067

Use of Ionic Liquids and Deep Eutectic Solvents in Polysaccharides Dissolution and Extraction Processes towards Sustainable Biomass Valorization

Morais, ES; Lopes, AMD; Freire, MG; Freire, CSR; Coutinho, JAP; Silvestre, AJD
2020, MOLECULES, 25, 16.
ISBN: 1420-3049

Grafting Poly(Methyl Methacrylate) (PMMA) from Cork via Atom Transfer Radical Polymerization (ATRP) towards Higher Quality of Three-Dimensional (3D) Printed PMMA/Cork-g-PMMA Materials

Lacerda, PSS; Gama, N; Freire, CSR; Silvestre, AJD; Barros-Timmons, A
2020, POLYMERS, 12, 9.
ISBN: 2073-4360

Active packaging

In Galanakis, Charis (Eds.), Sustainable Food Processing and Engineering Challenges
Carvalho, João P.F.; Freire, Carmen S.R.; Vilela, Carla
2021, Academic Press.
ISBN: 9780128227145

Modification of textiles for functional applications

In Md. Ibrahim H. Mondal (Eds.), Fundamentals of Natural Fibres and Textiles
Ana C. Q. Silva, Armando J. D. Silvestre, Carmen S. R. Freire, Carla Vilela
2021, 303-365, Elsevier.
ISBN: 9780128214831

Furanoate-Based Nanocomposites: A Case Study Using Poly(Butylene 2,5-Furanoate) and Poly(Butylene 2,5-Furanoate)-co-(Butylene Diglycolate) and Bacterial Cellulose

In George Z. Papageorgiou (Eds.), Polymers from Renewable Resources
Marina Matos, Andreia Sousa, Nuno H.C.S. silva, Carmen S.R. Freire, Márcia Andrade, Adélio Mnedes, Armando J.D. Silvestre
2018, MDPI.
ISBN: 978-3-03897-451-2

Development and applications of cellulose nanofibres based polymer nanocomposites

In Ehsan Bafekrpour (Eds.), Advanced Composite Materials: Properties and Applications
Carla Vilela, Ricardo J. B. Pinto, Ana R. P. Figueiredo, Carlos Pascoal Neto, Armando J. D. Silvestre, Carmen S. R. Freire
2017, 1-65, Warsaw/Berlin, De Gruyter Open.
ISBN: 9783110574432

Antimicrobial Properties and Therapeutic Applications of Silver Nanoparticles and Nanocomposites

In Alexandru Mihai Grumezesc (Eds.), Antimicrobial Nanoarchitectonics - From Synthesis to Applications
R.J.B. Pinto, M. Nasirpour, J. Carrola, H. Oliveira, C.S.R. Freire, I.F. Duarte
2017, 223-259, Elsevier.
ISBN: 978-0-323-52733-0

Polyethylene Terephthalate: Copolyesters, Composites, and Renewable Alternatives

In P. M. Visakh Mong Liang (Eds.), Poly(ethylene Terephthalate) Based Blends, Composites and Nanocomposites.
Andreia F. Sousa, Carla Vilela, Marina Matos, Carmen S.R. Freire, Armando J.D. Silvestre, Jorge F.J. Coelho
2015, 111-139, Elsevier Science Ltd.
ISBN: 9780323313063

Recent advances on the development of antibacterial polysaccharide-based materials, Chitosan, cellulose and starch

In Ramawat, Kishan Gopal, Mérillon, Jean-Michel (Eds.), Polysaccharides: Bioactivity and Biotechnology
V. Coma, C.S.R. Freire and A.J.D. Silvestre
2015, 1751-1803, New York, Springer International Publishing.
ISBN: 978-3-319-16297-3

Polyethylene Terephthalate: Copolyesters, Composites, and Renewable Alternatives

Andreia F. Sousa, Carla Vilela, Marina Matos, Carmen S.R. Freire, Armando J.D. Silvestre, Jorge F.J. Coelho
2015, Elsevier Inc..
ISBN: 978-0-323-31306-3

2 Bacterial  Cellulose-Based  Nanocomposites: Roadmap for Innovative Materials

Nanocellulose Polymer Nanocomposites: Fundamentals and Applications
A. R. P. Figueiredo, C. Vilela, C. Pascoal Neto, A.J.D. Silvestre and C.S.R. Freire
2014, Scrivener, Willey.
ISBN: 978-1-118-87190-4

The bulk oxypropylation of chitin and chitosan and the characterization of the ensuing polyols

In Senel S, Vårum KM Sumnu MM Hincal AA (Eds.), Advances In Chitin Science
Fernandes S, Freire CSR, Pascoal Neto C, Gandini A
2007, 10, 530-535, Antalya.
ISBN: 978-975-491-250-0

Biofuncionalização de nanocristais de celulose para o desenvolvimento de novos sistemas para tratamento e diagnóstico do cancro

Diogo Pinheiro
2018, supervised by Carmen Freire and Ricardo Pinto.

Biofuncionalização de nanocristais de celulose com ácido fólico para o desenvolvimento de novos sistemas para o diagnóstico e tratamento do cancro

Nicole Silva Lameirinhas
2017, supervised by Ricardo Pinto and Carmen Freire.

Biofuncionalização de nanocristais de celulose com ácido fólico para o desenvolvimento de novos sistemas para o diagnóstico e tratamento do cancro

Fátima Gabriela Guedes Faria
2017, supervised by Carmen Freire and Ricardo Pinto.

Biosynthesis of metallic nanostructures using natural extracts: study of structural and morphological features and evaluation of its therapeutic potential

Madalena Pinheiro Morais
2016, supervised by Ricardo Pinto and Carmen Freire .

Biosynthesis of metallic nanostructures using natural extracts: study of structural and morphological features and evaluation of its therapeutic potential

Catarina dos Reis Viegas
2015, supervised by Carmen Freire and Ricardo Pinto.

Green reduction of graphene oxide with Eucalyptus globulus bark extract

Mariana Rodrigues Ferreira da Silva
2015, supervised by Carmen Freire and Ricardo Pinto.

Characterization of new nanocomposites based on natural matrices (cellulose) and metallic nanostructures of copper

Kornelia Pielak
2014, supervised by Carmen Freire and Ricardo Pinto.

Desenvolvimento de novos nanomateriais híbridos a partir de biopolímeros e nanopartículas metálicas para aplicação em biosensores e catálise

Joana Filipa Martinho Lopes
2014, supervised by Carmen Freire and Ricardo Pinto.


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