Ana Maria Ferreira Takahashi

Junior Researcher

short cv

I obtained my MSc degree in Chemical Engineering from the University of Aveiro in 2013. In July of 2018, I completed my PhD in Chemical Engineering at the University of Aveiro, funded by Fundação para a Ciência e Tecnologia (FCT) through a PhD scholarship. During the PhD I had the opportunity to broaden my scientific skills abroad, through trainees at Universidade Estadual Paulista, Brazil, and Tokyo University of Agriculture, Japan. After finishing my PhD, I moved to the Technical University of Munich (TUM, one of the world's top universities), Germany, as a postdoctoral researcher, to work on the purification of compounds from microalgae in collaboration with the company Oceanbasis, with a TUM University Foundation Fellowship. This fellowship is awarded once a year by TUM, where ca. 10 young scientists are selected from all over the world. Currently, I am a researcher at UA working in the chiral resolution of drugs by enantioselective aqueous biphasic systems, being the importance of this work recognized in the international conference Biopartitioning & Purification 2019 (BR) with the award for best presentation poster sponsored by Elsevier. Up to the data, I am in 2 funded R&D projects. I am PI of 1 funded project (POCI-01-0145-FEDER-030750, 239893 EUR), and team member in another funded project (POCI-01-0247-FEDER-045304, 297976 EUR) in collaboration with the company Mistolin. Overall, in these last years, I gathered a vast knowledge on the development of sustainable extraction/purification platforms (using both solid- and liquid-liquid extraction) of compounds from different matrices, showing my commitment to science in the benefit of the environment and society.

Since the beginning of my research activities, I filled 1 national patent, published 2 book chapters, 18 SCI papers and 1 journal cover, with 600+ citations and an h-index of 13. I have published in various high IF journals, namely Green Chem (IF 9.48, 8/18 SCI), ACS Sustain Chem Eng (IF 7.63), Chem Commun (IF 5.99), Sep Purif Technol (IF 5.77) and others. I am the first author in 9/18 SCI papers and worked with 43 co-authors. Moreover, I contributed with 90+ communications.


2014-2018: PhD in Chemical Engineering, Department of Chemistry, University of Aveiro, Portugal.

2008-2013: MSc in Chemical Engineering, Department of Chemistry, University of Aveiro, Portugal.

research area

Chemical Engineering

Development of innovative, integrated and sustainable processes for the extraction and separation of value-added compounds (alkaloids, amino acids, phenolic acids and others natural compounds) with therapeutic features from biomass, as well as wastes, using aqueous solutions of ionic liquids and surfactants, within a biorefinery perspective (circular economy).



Development of cost-effective purification and recovery processes for several value‐added biopharmaceuticals, namely proteins, enzymes, antibodies, and nucleic‐acids‐based products.


Chemistry/Physical Chemistry

Understand the molecular‐level mechanisms which rule the liquid-liquid equilibria and the extraction performance of separation processes, by the determination of thermodynamic properties of solution, solvation and transfer.



Using COSMO-RS in the Design of Deep Eutectic Solvents for the Extraction of Antioxidants from Rosemary

Wojeicchowski, JP; Ferreira, AM; Abranches, DO; Mafra, MR; Coutinho, JAP

Recovery of Syringic Acid from Industrial Food Waste with Aqueous Solutions of Ionic Liquids

de Faria, ELP; Ferreira, AM; Claudio, AFM; Coutinho, JAP; Silvestre, AJD; Freire, MG

Continuous separation of cytochrome-c PEGylated conjugates by fast centrifugal partition chromatography

Santos, JHPM; Ferreira, AM; Almeida, MR; Quinteiro, PSGN; Dias, ACRV; Coutinho, JAP; Freire, MG; Rangel-Yagui, CO; Ventura, SPM
2019, GREEN CHEMISTRY, 21, 20, 5501-5506.
ISBN: 1463-9270

Cloud Point Extraction of Chlorophylls from Spinach Leaves Using Aqueous Solutions of Nonionic Surfactants

Leite, AC; Ferreira, AM; Morais, ES; Khan, I; Freire, MG; Coutinho, JAP

An integrated process for enzymatic catalysis allowing product recovery and enzyme reuse by applying thermoreversible aqueous biphasic systems

Ferreira, AM; Passos, H; Okafuji, A; Tavares, APM; Ohno, H; Freire, MG; Coutinho, JAP
2018, GREEN CHEMISTRY, 20, 6, 1218-1223.

Enhanced separation performance of aqueous biphasic systems formed by carbohydrates and tetraalkylphosphonium- or tetraalkylammonium-based ionic liquids

Quental, MV; Pereira, MM; Ferreira, AM; Pedro, SN; Shahriari, S; Mohamadou, A; Coutinho, JAP; Freire, MG
2018, GREEN CHEMISTRY, 20, 13, 2978-2983.

Designing the thermal behaviour of aqueous biphasic systems composed of ammonium-based zwitterions

Ferreira, AM; Passos, H; Okafuji, A; Freire, MG; Coutinho, JAP; Ohno, H
2017, GREEN CHEMISTRY, 19, 17, 4012-4016.

Enhanced extraction and biological activity of 7-hydroxymatairesinol obtained from Norway spruce knots using aqueous solutions of ionic liquids

Ferreira, AM; Morais, ES; Leite, AC; Mohamadou, A; Holmbom, B; Holmbom, T; Neves, BM; Coutinho, JAP; Freire, MG; Silvestre, AJD
2017, GREEN CHEMISTRY, 19, 11, 2626-2635.

Switchable (pH-driven) aqueous biphasic systems formed by ionic liquids as integrated production-separation platforms

Ferreira, AM; Claudio, AFM; Valega, M; Domingues, FMJ; Silvestre, AJD; Rogers, RD; Coutinho, JAP; Freire, MG
2017, GREEN CHEMISTRY, 19, 12, 2768-2773.

Are Aqueous Biphasic Systems Composed of Deep Eutectic Solvents Ternary or Quaternary Systems?

Passos, H; Tavares, DJP; Ferreira, AM; Freire, MG; Coutinho, JAP

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