Vítor Félix

Associate Professor with Aggregation

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Department

  • Chemistry
  • 30A.3.24

Research

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résumé

Education:

  • PhD in Chemistry, Instituto Superior Técnico, Lisbon, Portugal (1993)

 

  • Graduated in Applied Chemistry (Organic Chemistry), Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa, Lisbon, Portugal (1986)

 

Academic Career:

  • Associate Professor with Aggregation (2008-present)

 

  • Associate Professor (2000-2008)

 

  • Auxiliary Professor(1997-2000)

 

  • Auxiliary Invited Professor (1994-1997)

 

  • Assistant Professor (1993-1994)

 

  • Visiting Scientist at University of Reading, with Professor Michael Drew (1994 and 2001)

 

Researcher ID

molecular modelling group

The research field of our modelling group includes both experimental and computational areas of supramolecular chemistry, in the following research lines

 

Computer modelling of drug-biological target interactions;

 

Theoretical investigation of halogen bonds in interlocked and/or macrocyclic receptors;

                    

 

Molecular design of artificial receptors for anion recognition;

                   

 

 

Computational studies of the diffusion of delivery-systems in cellular membrane models.

 

The computational research includes mainly quantum calculations and molecular dynamics simulations. The experimental structural studies are carried out primarily through single crystal X-ray diffraction using a CCD system. Our group is currently hosted at the Department of Health Sciences.

Most of these research topics are part of our extensive international scientific network (more details bellow).

 

Further information about our group can be found at the Molecular Modeling Group site.

selected publications

  • S. J. Moore, C. J. E. Haynes, J. Gonzalez, J. L. Sutton, S. J. Brooks, M. E. Light, J. Herniman, G. J. Langley, V. Soto-Cerrato, R. Perez-Tomas, I. Marques, P. J. Costa, V. Felix and P. A. Gale, Chem. Sci., 2013, 4, 103-117.[link]
  • F. Zapata, A. Caballero, N. G. White, T. D. Claridge, P. J. Costa, V. Felix and P. D. Beer, J. Am. Chem. Soc., 2012, 134, 11533-11541.[link]
  • A. I. Vicente, J. M. Caio, J. Sardinha, C. Moiteiro, R. Delgado and V. Felix, Tetrahedron, 2012, 68, 670-680.[link]
  • J. D. Ingram, P. J. Costa, H. Adams, M. D. Ward, V. Felix and J. A. Thomas, Inorg. Chem., 2012, 51, 10483-10494.[link]
  • C. J. E. Haynes, S. J. Moore, J. R. Hiscock, I. Marques, P. J. Costa, V. Felix and P. A. Gale, Chem. Sci., 2012, 3, 1436-1444.[link]
  • A. Caballero, F. Zapata, N. G. White, P. J. Costa, V. Felix and P. D. Beer, Angew. Chem. Int. Ed. Engl., 2012, 51, 1876-1880.[link]
  • C. J. Serpell, N. L. Kilah, P. J. Costa, V. Felix and P. D. Beer, Angew. Chem. Int. Ed. Engl., 2010, 49, 5322-5326.[link]
  • S. M. Santos, P. J. Costa, M. D. Lankshear, P. D. Beer and V. Felix, J. Phys. Chem. B, 2010, 114, 11173-11180.[link]
  • N. M. Micaelo, A. L. Macedo, B. J. Goodfellow and V. Felix, J. Mol. Graph. Model., 2010, 29, 396-405.[link]
  • C. Cruz, V. Calisto, R. Delgado and V. Felix, Chem. Eur. J., 2009, 15, 3277-3289.[link]
  • M. D. Lankshear, I. M. Dudley, K. M. Chan, A. R. Cowley, S. M. Santos, V. Felix and P. D. Beer, Chem. Eur. J., 2008, 14, 2248-2263.[link]
  • H. Adams, P. J. Costa, M. Newell, S. J. Vickers, M. D. Ward, V. Felix and J. A. Thomas, Inorg. Chem., 2008, 47, 11633-11643.[link]
  • C. Cruz, R. Delgado, M. G. Drew and V. Felix, J. Org. Chem., 2007, 72, 4023-4034.[link]
  • V. Felix, M. G. Drew, P. R. Webber and P. D. Beer, Phys. Chem. Chem. Phys., 2006, 8, 521-532.[link]

international research collaborations

Professor Paul D. Beer [link]

Inorganic Chemistry, Department of Chemistry

University of Oxford

 

Professor Jim A. Thomas [link]

Reader in Coordination Chemistry

University of Sheffield

 

Professor Phil A Gale [link]

Head of Chemistry, Professor of Supramolecular Chemistry

University of Southampton

 

Doctor Roberto Quesada [link]

Departamento de Química de la Facultad de Ciencias

Universidad de Burgos

 

Professor Raj Pal Sharma [link]

Department of Chemistry

University of Panjab

national research collaborations

Doutora Cristina Moiteiro [link]

Departamento de Química e Bioquímica

Univeridade de Lisboa -  Faculdade de Ciências

 

Doutora Paula Brandão [link]

Departamento de Química

Universidade de Aveiro

Projects

Anion transmembrane transport promoted by drug-like molecules: building a library of anion carriers inspired in Ataluren (PTC124) (PTDC/QEQ-SUP/4283/2014)

CoordinatorFundação para a Ciência e a Tecnologia

Creating custom microenvironments for anion complexation in water (DP210100039)

Local CoordinatorOther International
Creating custom microenvironments for anion complexation in water. This proposal will exploit a new strategy in the design of anion receptors that function in water by employing the microenvironment formed in aggregates of these molecules. The outcome of the project will be a series of new materials designed to selective bind particular anions, ...

Development of azacalix(hetero)arene transporters for mediated anionic flux across membranes: a novel approach for studying ionic passive diffusion (PTDC/QUI-QUI/101022/2008)

CoordinatorFundação para a Ciência e a Tecnologia
Transmembrane anion transport Aza-bridged calix(hetero)aromatic receptors Anion binding Supramolecular chemistry

Molecular design of novel aza-bridged calixarene receptors for medicinal chemistry: encapsulation of lanthanide ions and chiral resolution of drugs (PTDC/QUI/68582/2006)

CoordinatorFundação para a Ciência e a Tecnologia
Azacalix[2]arene[2]triazine Lanthanide complexes Molecular recognition Enantioselective resolution

Molecular hybrids of polyoxometalates and dipolar organic molecules: synthesis, characterization and determination of non-linear optical properties (POCTI/CTM/37713/2001)

PartnerFundação para a Ciência e a Tecnologia
polyoxometalate optical nonlinearity organic/inorganic hybrid nonlinear optical materials

Molecular recognition of phthalate and phthalic acid esters pollutants by ditopic receptors or by cascade dicopper systems (POCI/QUI/56569/2004)

Local CoordinatorFundação para a Ciência e a Tecnologia
Molecular recognition macrocycles and cryptands Supramolecular Chemistry phthalate and phthalic acid esters

Structural and functional studies of the soul/hbp family of heme-binding proteins (PTDC/QUI/64203/2006)

PartnerFundação para a Ciência e a Tecnologia
heme binding NMR SOUL/HBP family structure and function

Publications

Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications

Sousa, V; Amaral, AR; Castanheira, EJ; Marques, I; Rodrigues, JMM; Félix, V; Borges, J; Mano, JF
2023, BIOMACROMOLECULES, 24, 7, 3380-3396.

Fullerene-Functionalized Halogen-Bonding Heteroditopic Hosts for Ion-Pair Recognition

Bak, KM; Marques, I; Kuhn, H; Christensen, KE; Félix, V; Beer, PD
2023, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 145, 50, 27367-27379.

Being Positive is Not Everything - Experimental and Computational Studies on the Selectivity of a Self-Assembled, Multiple Redox-State Receptor that Binds Anions with up to Picomolar Affinities

Zubi, A; Alnafisah, HA; Turega, S; Marques, I; Gomes, JRB; Thomas, JA; Felix, V
2022, CHEMISTRY-A EUROPEAN JOURNAL, 28, 5.

Binding and Transport Properties of a Benzo[b]thiophene-Based Mono-(thio)urea Library

Moiteiro, C; Marques, I; Ryder, WG; Cachatra, V; Carvalho, S; Chen, LJ; Goodfellow, BJ; Gale, PA; Felix, V
2022, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 3.

Selective Potassium Chloride Recognition, Sensing, Extraction, and Transport Using a Chalcogen-Bonding Heteroditopic Receptor

Docker, A; Marques, I; Kuhn, H; Zhang, ZY; Felix, V; Beer, PD
2022, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 144, 32, 14778-14789.

Hydrazones in anion transporters: the detrimental effect of a second binding site

Martinez-Crespo, L; Halgreen, L; Soares, M; Marques, I; Felix, V; Valkenier, H
2021, ORGANIC & BIOMOLECULAR CHEMISTRY, 19, 38, 8324-8337.
ISBN: 1477-0539

Hydrosulfide (HS-) Recognition and Sensing in Water by Halogen Bonding Hosts

Mitchell, EJ; Beecroft, AJ; Martin, J; Thompson, S; Marques, I; Felix, V; Beer, PD
2021, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60, 45, 24048-24053.
ISBN: 1521-3773

Synthesis, characterization, X-ray crystal structure and antibacterial activity of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide

Dhau, JS; Singh, A; Brandao, P; Felix, V
2021, INORGANIC CHEMISTRY COMMUNICATIONS, 133.
ISBN: 1879-0259

New heptacoordinate tungsten(II) complexes with α-diimine ligands in the catalytic oxidation of multifunctional olefins

Vasconcellos-Dias, M; Nunes, CD; Felix, V; Brandao, P; Calhorda, MJ
2021, INORGANICA CHIMICA ACTA, 519.
ISBN: 1873-3255

Development of a Library of Thiophene-Based Drug-Like Lego Molecules: Evaluation of Their Anion Binding, Transport Properties, and Cytotoxicity

Vieira, P; Miranda, MQ; Marques, I; Carvalho, S; Chen, LJ; Howe, ENW; Zhen, C; Leung, CY; Spooner, MJ; Morgado, B; Silva, OABDE; Moiteiro, C; Gale, PA; Felix, V
2020, CHEMISTRY-A EUROPEAN JOURNAL, 26, 4, 888-899.
ISBN: 1521-3765

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